Results 121 to 130 of about 79,654 (277)

Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches

Obesity, Volume 34, Issue 2, Page 417-427, February 2026.
ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Hunter G. Sellers, Zachary L. Brown, Noureen S. Khalil, Stephen B. Haigh, Mitchell A. Shivers, Tej V. Patel, Austin T. Joshua, Neal L. Weintraub, Scott A. Barman, Eric J. Belin de Chantemele, Sergei A. Kirov, David W. Stepp, David J. R. Fulton   +12 more
wiley   +1 more source

Adrenalectomy alters the sensitivity of the central nervous system melanocortin system [PDF]

, 2003
Removal of adrenal steroids by adrenalectomy (ADX) reduces food intake and body weight in rodents and prevents excessive weight gain in many genetic and dietary models of obesity. Thus, glucocorticoids appear to play a key role to promote positive energy
Clegg, DJ, Drazen, Deborah L., Drazen, DL, Schwartz, Michael W., Schwartz, MW, Seeley, Randy J., Seeley, RJ, van Dijk, G, Woods, SC, Woods, Stephen C., Wortman, Matthew D., Wortman, MD   +11 more
core   +2 more sources

Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity

Obesity, Volume 34, Issue 2, Page 499-511, February 2026.
ABSTRACT Objective Pathogenic variants in five established leptin‐melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early‐onset obesity and are targets for emerging treatments. However, these variants are rare in these patients, suggesting the involvement of additional genes interacting with this pathway. Methods Next‐
Nathan Faccioli, Chrisitne Poitou, Mathieu Georget, Françoise Bertin, Ahlam Azar‐Kolakez, Claire Carette, Pauline Faucher, Blandine Gatta‐Cherifi, Julie Gonneau‐Lejeune, Agnès Linglart, Karine Clément, Johanne Le Beyec‐Le Bihan, Béatrice Dubern   +12 more
wiley   +1 more source

Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. [PDF]

, 2013
Second-generation antipsychotic exposure, in both children and adults, carries significant risk for excessive weight gain that varies widely across individuals.
Aman, MG, Arnold, LE, Handen, B, Johnson, C, Lecavalier, L, McCracken, JT, McDougle, CJ, Nurmi, EL, Posey, DJ, Research Units on Pediatric Psychopharmacology Autism Network, Ritz, L, Scahill, LL, Spilman, SL, Stigler, KA, Sukhodolsky, DG, Tierney, E, Vitiello, B, Whelan, F   +17 more
core   +1 more source

From Permits to Samples: Addressing Key Challenges for High‐Quality Reference Genome Generation in Europe

Molecular Ecology Resources, Volume 26, Issue 2, February 2026.
ABSTRACT High‐quality reference genome assemblies have become essential for deepening our understanding of biodiversity, yet obtaining them for many species remains surprisingly challenging. Drawing on experiences from the European Reference Genome Atlas (ERGA) community, we focus on permit and sample‐handling procedures leading up to nucleic acid ...
Katja Reichel, Jaakko Pohjoismäki, Jonas J. Astrin, Astrid Böhne, Chiara Bortoluzzi, Elena Bužan, Javier del Campo, Claudio Ciofi, Camilla B. Di‐Nizo, Pradeep K. Divakar, Carola Greve, Vladimír Hampl, Leon Hilgers, Veronika N. Laine, Jennifer A. Leonard, Jesus Lozano‐Fernandez, Lada Lukić Bilela, Camila J. Mazzoni, Ann M. McCartney, José Melo‐Ferreira, Rita Monteiro, Rebekah A. Oomen, Martina Pavlek, João Pimenta, Michal Rindos, Ole Seehausen, Andrii Tarieiev, Salvatore Tomasello, Olga Vinnere Pettersson, Robert M. Waterhouse, Alexandra A.‐T. Weber, Oleksandr Zinenko, Christian de Guttry   +32 more
wiley   +1 more source

Distinct binding and signaling activity of Acthar Gel compared to other melanocortin receptor agonists [PDF]

, 2020
Ying-Su Huang, Karen P. Galen, Ben S. Zweifel, Leah R. Brooks, Albion D. Wright   +4 more
openalex   +1 more source

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

Local Agouti Signaling Protein/Melanocortin Signaling System that Possibly Regulates Lipid Metabolism in Adipose Tissues of Chickens

The Journal of Poultry Science, 2010
The agouti signaling protein (ASIP)/melanocortin signaling system regulates lipid metabolism in humans but not in mice. To examine whether the system is present in adipose tissues in chickens, we performed reverse transcription-polymerase chain reaction
Masafumi Yabuuchi, Kana Bando, Misato Hiramatsu, Sumio Takahashi, Sakae Takeuchi   +4 more
doaj   +1 more source

Regulation of energy rheostasis by the melanocortin-3 receptor

Science Advances, 2018
The melanocortin-3 receptor acts as a rheostat on energy homeostasis through presynaptic inhibition of MC4R neuronal activity. Like most homeostatic systems, adiposity in mammals is defended between upper and lower boundary conditions.
M. Ghamari-Langroudi, Işın Çakır, R. Lippert, P. Sweeney, Michael J. Litt, K. Ellacott, R. Cone   +6 more
semanticscholar   +1 more source