Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3’UTR
Frontiers in Cellular Neuroscience, 2015 The central nervous system monitors modifications in metabolic parameters or hormone levels and elicits adaptive responses such as food intake regulation. Particularly, within the hypothalamus, leptin modulates the activity of pro-opiomelanocortin (POMC)
Adel eDerghal +10 more
doaj +1 more source
The stimulatory G protein Gsα is required in melanocortin 4 receptor–expressing cells for normal energy balance, thermogenesis, and glucose metabolism [PDF]
, 2018 Brandon Podyma +7 more
openalex +1 more source
KNDy neurons as an indirect target of insulin‐like growth factor‐1
Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.Abstract Neurons in the arcuate nucleus of the hypothalamus (ARH) that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy neurons) are considered the gonadotropin‐releasing hormone (GnRH) pulse generator necessary for fertility. KNDy neurons are also metabolic sensors controlling the hypothalamic–pituitary‐gonadal (HPG) axis.
Josiane do N. Silva +8 more
wiley +1 more source
Melanism as a potential thermal benefit in eastern fox squirrels (Sciurus niger) [PDF]
, 2019 Melanistic fox squirrels (Sciurus niger) have expanded westward and increased in frequency in the Omaha, Nebraska, and Council Bluffs, Iowa, metropolitan areas.
Ciurej, Amanda K. +3 more
core +2 more sources
Effect of Novel Melanocortin Type 2 Receptor Antagonists on the Corticosterone Response to ACTH in the Neonatal Rat Adrenal Gland In Vivo and In Vitro [PDF]
, 2016 Nasha K. Nensey +3 more
openalex +1 more source
Targeting Melasma: Innovations in Pigment Deposition and Photoaging in Cosmetic Dermatology
Journal of Cosmetic Dermatology, Volume 25, Issue 1, January 2026.ABSTRACT Background Melasma is a chronic, relapsing hyperpigmentation disorder driven by complex interactions among genetic predisposition, hormonal fluctuations, UV exposure, oxidative stress, inflammation, and photoaging. Its psychosocial impact is substantial, especially among women with darker skin types, and treatment remains challenging due to ...
Ting Liao +4 more
wiley +1 more source
Funktionelle Konsequenzen von Mutationen im Melanocortin-4-Rezeptorgen bei adipösen Kindern und Jugendlichen [PDF]
, 2006 Der Melanocortin-4-Rezeptor spielt eine zentrale Rolle in der Gewichtsregulation, er vermittelt (indirekt) die anorexigenen Effekte des Leptin, indem er nach Aktivierung eine Einstellung der Nahrungsaufnahme und eine Erhöhung der Stoffwechselrate ...
Gudermann, Thomas (Prof. Dr.) +1 more
core +1 more source
Development of the Hypothalamic Melanocortin System
Frontiers in Endocrinology, 2013 The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R ...
Berengere eCoupe, Sebastien G Bouret
doaj +1 more source
Melanocortins, Melanocortin Receptors and Multiple Sclerosis
Brain Science, 2017 The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis.
R. Lisak, J. Benjamins
semanticscholar +1 more source