Results 151 to 160 of about 48,562 (195)
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Melanocortins and their implication in melanoma
Trends in Endocrinology & Metabolism, 1995The melanocortins (MCs), that is, the melanocyte-stimulating hormones (MSHs) and ACTH, are a group of related peptides containing the typical melanotropin core sequence, His-Phe-Arg-Trp, and are derived from a common precursor, pro-opiomelanocortin.
W, Siegrist, A N, Eberle
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Characterization of Melanocortin Receptors
Current Protocols in Pharmacology, 2003AbstractThis unit describes a Scintillation Proximity Assay (SPA) for the measurement of ligand binding to melanocortin receptors (MCRs) using membranes prepared from cell lines stably expressing recombinant MCRs. It provides a facile method for determining the affinity of compounds at MC1R, MC3R, MC4R, or MC5R.
Aaron S, Goetz, Diane M, Ignar
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Melanocortin Signalling Mechanisms
2010The melanocortin family are a series of very potent neuropeptides that derive from a parent propopiomelanocortin molecule (POMC). They are expressed predominantly in the brain, specifically the pituitary gland and also in the central nervous system. Interestingly, recent research also suggests the existence of regulatory functions outside of the brain,
Paula Eves, J. W. Haycock
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Evolution of the melanocortin system
General and Comparative Endocrinology, 2014The melanocortin system is one of the most complex of the hormonal systems. It involves different agonists encoded in the multiplex precursor proopiomelanocortin (POMC) or in different genes as β-defensins, endogenous antagonist, like agouti-signalling protein (ASIP) or agouti-related protein (AGRP), and five different melanocortin receptors (MCRs ...
Cortés, Raúl +6 more
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Melanocortins and their Receptors and Antagonists
Current Drug Targets, 2003The melanocortins are a group of small protein hormones derived by post-translational cleavage of the proopiomelanocortin (POMC) gene product. The known melanocortin hormones include alpha-melanocyte stimulating hormone (MSH), beta-MSH, gamma-MSH and adrenocorticotropic hormone (ACTH).
Voisey, J, Carroll, L, van Daal, A
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Melanocortins in Brain Inflammation: The Role of Melanocortin Receptor Subtypes
2010The melanocortins (MC) are released from neurons and paracrine cells in the CNS where they are involved in important physiological functions, including regulation of body temperature and immune responses. MC bind to melanocortin receptors, a class of cell surface G-protein-coupled receptors. Of the five subtypes of MC receptors that have been cloned in
Ruta, Muceniece, Maija, Dambrova
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Melanocortins and Adrenocortical Function
2000Although the existence of a functional relationship between the pituitary gland and the adrenal cortex was revealed by the classic studies of Smith almost seventy years ago (1),the first purified adrenocorticotropin (ACTH) preparation from sheep pituitary was obtained only in 1954 (2), and its structure was determined in the following few years (3). In
Bégeot, Martine, Saez, J.M.
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The Journal of Pharmacology and Experimental Therapeutics, 1995
The melanocortins are peptide products of proopiomelanocortin post-translational processing that, among other functions, are thought to influence cognition. Recently, we isolated genes encoding two human melanocortin receptors, the melanocortin-3 receptor (hMC3R) and the melanocortin-4 receptor (hMC4R), which are expressed primarily in brain.
H, Miwa +4 more
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The melanocortins are peptide products of proopiomelanocortin post-translational processing that, among other functions, are thought to influence cognition. Recently, we isolated genes encoding two human melanocortin receptors, the melanocortin-3 receptor (hMC3R) and the melanocortin-4 receptor (hMC4R), which are expressed primarily in brain.
H, Miwa +4 more
openaire +2 more sources