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Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling [PDF]

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses.
Anni Suominen   +9 more
doaj   +5 more sources

Melanocortin 1 Receptor: Structure, Function and Regulation [PDF]

open access: yesFrontiers in Genetics, 2016
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma ...
Erin Marissa Wolf Horrell   +2 more
doaj   +5 more sources

Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease [PDF]

open access: goldMolecular Neurodegeneration, 2022
Background Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD).
Waijiao Cai   +10 more
doaj   +4 more sources

Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission Tomography [PDF]

open access: yesMolecular Imaging, 2018
Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Yongfeng Zhao PhD   +8 more
doaj   +4 more sources

ACTH antagonists [PDF]

open access: yesFrontiers in Endocrinology, 2016
ACTH acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R) is unusual in that it is absolutely dependent on ...
Adrian John Clark   +6 more
doaj   +5 more sources

Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver [PDF]

open access: yeseLife, 2023
Melanocortin 1 receptor (MC1-R) is widely expressed in melanocytes and leukocytes and is thus strongly implicated in the regulation of skin pigmentation and inflammation.
Keshav Thapa   +7 more
doaj   +2 more sources

A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans [PDF]

open access: yesFrontiers in Immunology, 2023
IntroductionPL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model.
John Dodd   +8 more
doaj   +2 more sources

Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis [PDF]

open access: yesFrontiers in Endocrinology, 2022
The melanocortin system consists of five G protein–coupled receptors (MC1R-MC5R), the bidirectional endogenous ligands (MSH and Agouti families), and accessory proteins (MRAP1 and MRAP2).
Xiaolu Tai   +8 more
doaj   +2 more sources

Melanogenic effect of dersimelagon (MT‐7117), a novel oral melanocortin 1 receptor agonist [PDF]

open access: yesSkin Health and Disease, 2022
Background The activation of melanocortin 1 receptor (MC1R) on melanocytes stimulates the production of eumelanin. A tridecapeptide α melanocyte‐stimulating hormone (αMSH) is known to induce skin pigmentation.
T. Suzuki   +12 more
doaj   +2 more sources

L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

open access: greenFrontiers in Endocrinology, 2021
The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans but ...
Rune E. Kuhre   +15 more
doaj   +3 more sources

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