Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2 [PDF]
Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj +3 more sources
Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E-/- Mice. [PDF]
Arterioscler Thromb Vasc Biol, 2018 Objective— The MC1-R (melanocortin 1 receptor) is expressed by monocytes and macrophages where it mediates anti-inflammatory actions. MC1-R also protects against macrophage foam cell formation primarily by promoting cholesterol efflux through the ABCA1 (ATP-binding cassette transporter subfamily A member 1) and ABCG1 (ATP ...
Rinne P +8 more
europepmc +7 more sources
Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji +2 more
doaj +3 more sources
Effects of melanocortin 1 receptor agonists in experimental nephropathies. [PDF]
PLoS ONE, 2014 Nephrotic syndrome, characterized by massive proteinuria, is caused by a large group of diseases including membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS).
Annika Lindskog Jonsson +5 more
doaj +5 more sources
Functional divergence of the pigmentation gene melanocortin-1 receptor (MC1R) in six endemic Macaca species on Sulawesi Island. [PDF]
Sci Rep, 2022 Yan X +7 more
europepmc +3 more sources
Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage [PDF]
Redox BiologyCutaneous melanoma, a lethal skin cancer, arises from malignant transformation of melanocytes. Solar ultraviolet radiation (UVR) is a major environmental risk factor for melanoma since its interaction with the skin generates DNA damage, either directly ...
María Castejón-Griñán +7 more
doaj +2 more sources
Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects. [PDF]
Int J Mol Sci, 2023 Melanocortins play crucial roles in regulating the stress response, inflammation, and skin pigmentation. In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and exhibiting anti-inflammatory effects.
Mun Y, Kim W, Shin D.
europepmc +3 more sources
Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. [PDF]
Nat Commun, 2023 Cui Y +8 more
europepmc +3 more sources
7,3',4'-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses α-Melanocyte-Stimulating Hormone-Induced Melanogenesis by Targeting Melanocortin 1 Receptor. [PDF]
Front Mol Biosci, 2020 Kim JH +9 more
europepmc +3 more sources
Melanocortin 1 Receptor Agonists Reduce Proteinuria [PDF]
Journal of the American Society of Nephrology, 2010 Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults. Recent reports suggest that treatment with adrenocorticotropic hormone (ACTH) reduces proteinuria, but the mechanism of action is unknown. Here, we identified gene expression of the melanocortin receptor MC1R in podocytes, glomerular endothelial cells, mesangial ...
Annika Lindskog +8 more
openalex +4 more sources