Results 21 to 30 of about 60,692 (262)

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor. [PDF]

Proc Natl Acad Sci U S A, 2019
Ozdeslik RN, Olinski LE, Trieu MM, Oprian DD, Oancea E.   +4 more
europepmc   +3 more sources

Amplification of the Melanocortin-1 Receptor in Nephrotic Syndrome Identifies a Target for Podocyte Cytoskeleton Stabilization. [PDF]

Sci Rep, 2018
Bergwall L, Wallentin H, Elvin J, Liu P, Boi R, Sihlbom C, Hayes K, Wright D, Haraldsson B, Nyström J, Buvall L.   +10 more
europepmc   +3 more sources

Melanocortin 1 Receptor Variants in an Irish Population [PDF]

Journal of Investigative Dermatology, 1998
The identification of an association between variants in the human melanocortin 1 receptor (MC1R) gene and red hair and fair skin, as well as the relation between variants of this gene and coat color in animals, suggests that the MC1R is an integral control point in the normal pigmentation phenotype.
Rachel Vickers‐Smith, Eugene Healy, Shazia Siddiqui, Niamh Flanagan, Peter M. Steijlen, Inger Rosdahl, Jon P. Jacques, S Rogers, Richard Turner, Ian J. Jackson, Mark A. Birch‐Machin, Jonathan L. Rees   +11 more
openalex   +4 more sources

Skin Type, Melanoma, and Melanocortin 1 Receptor Variants [PDF]

Journal of Investigative Dermatology, 1999
Eugene Healy, Carole Todd, Ian J. Jackson, Mark A. Birch‐Machin, Jonathan L. Rees   +4 more
openalex   +4 more sources

Detecting Melanocortin 1 Receptor Gene's SNPs by CRISPR/enAsCas12a. [PDF]

Genes (Basel), 2023
Beyond its powerful genome-editing capabilities, the CRISPR/Cas system has opened up a new era of molecular diagnostics due to its highly specific base recognition and trans-cleavage activity. However, most CRISPR/Cas detection systems are mainly used to detect nucleic acids of bacteria or viruses, while the application of single nucleotide ...
Yang W, Tao D, Xu B, Zheng Y, Zhao S.
europepmc   +3 more sources

High Polymorphism at the Human Melanocortin 1 Receptor Locus [PDF]

Genetics, 1999
Abstract Variation in human skin/hair pigmentation is due to varied amounts of eumelanin (brown/black melanins) and phaeomelanin (red/yellow melanins) produced by the melanocytes. The melanocortin 1 receptor (MC1R) is a regulator of eu- and phaeomelanin production in the melanocytes, and MC1R mutations causing coat color changes are ...
Brinda K. Rana, David Hewett‐Emmett, Jin Li, Benny H-J Chang, Naymkhishing Sambuughin, Marie Lin, Scott Watkins, Michael J. Bamshad, Lynn B. Jorde, Michèle Ramsay, Trefor Jenkins, Wen‐Hsiung Li   +11 more
openalex   +3 more sources

Expression of melanocortin 1 receptor before and after narrowband UVB phototherapy treatment in patients with stable vitiligo: A prospective study. [PDF]

Exp Ther Med, 2020
Ocampo-Garza J, Salinas-Santander M, Welsh O, Herz-Ruelas M, Ocampo-Candiani J.   +4 more
europepmc   +3 more sources

Fingolimod and Diabetic Retinopathy: A Drug Repurposing Study

Frontiers in Pharmacology, 2021
This study aimed to investigate the interactions between fingolimod, a sphingosine 1-phosphate receptor (S1PR) agonist, and melanocortin receptors 1 and 5 (MCR1, MCR5).
Carlo Gesualdo, Cornel Balta, Chiara Bianca Maria Platania, Maria Consiglia Trotta, Hildegard Herman, Sami Gharbia, Marcel Rosu, Francesco Petrillo, Salvatore Giunta, Alberto Della Corte, Paolo Grieco, Rosa Bellavita, Francesca Simonelli, Michele D’Amico, Anca Hermenean, Anca Hermenean, Settimio Rossi, Claudio Bucolo   +17 more
doaj   +1 more source

Journey through the spectacular landscape of melanocortin 1 receptor. [PDF]

Pigment Cell Melanoma Res
AbstractThe physiological role of α‐melanocyte stimulating hormone in regulating integumental pigmentation of many vertebrate species has been recognized since the 1960's. However, its physiological significance for human pigmentation remained enigmatic until the 1990's. α‐Melanocyte stimulating hormone and related melanocortins are synthesized locally
Upadhyay PR, Swope VB, Starner RJ, Koikov L, Abdel-Malek ZA.   +4 more
europepmc   +3 more sources

Localization of Melanocortin 1 Receptor in the Substantia Nigra. [PDF]

Int J Mol Sci
Recent findings have revealed that melanocortin 1 receptor (MC1R) deficiency leads to Parkinson’s disease-like dopaminergic neurodegeneration in the substantia nigra (SN). However, its precise distribution and expressing-cell type in the SN remain unclear.
Ehara A, Ito N, Nakadate K, Tokuda N.
europepmc   +3 more sources