Results 41 to 50 of about 60,692 (262)

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike, Cerdá-Reverter, José Miguel, Heyder, Nicolas, Kleinau, Gunnar, Krude, Heiko, Kwiatkowski, Dennis, Kühnen, Peter, Scheerer, Patrick, Soletto, Lucia, Speck, David, Szczepek, Michal   +10 more
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Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]

, 2019
The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan, Chen, Valerie, Hoang, Ivy, Kawamura, Tomoya, McBride, Ryan, Millhauser, Glenn L, Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Wong, Ashley Tess, Yang, Yang   +9 more
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Data for amino acid alignment of Japanese stingray melanocortin receptors with other gnathostome melanocortin receptor sequences, and the ligand selectivity of Japanese stingray melanocortin receptors

Data in Brief, 2016
This article contains structure and pharmacological characteristics of melanocortin receptors (MCRs) related to research published in “Characterization of melanocortin receptors from stingray Dasyatis akajei, a cartilaginous fish” (Takahashi et al., 2016)
Akiyoshi Takahashi, Perry Davis, Christina Reinick, Kanta Mizusawa, Tatsuya Sakamoto, Robert M. Dores   +5 more
doaj   +1 more source

The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]

, 2015
The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Arble, Deanna M., Herman, James P., Holland, Jenna, Morano, Rachel, Ottaway, Nickki, Perez-Tilve, Diego, Pressler, Joshua W., Sandoval, Darleen A., Seeley, Randy J., Sorrell, Joyce, Woods, Stephen C.   +10 more
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MRAP2 regulates ghrelin receptor signaling and hunger sensing

Nature Communications, 2017
Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling.
Dollada Srisai, Terry C. Yin, Abigail A. Lee, Alix A. J. Rouault, Nicole A. Pearson, Justin L. Grobe, Julien A. Sebag   +6 more
doaj   +1 more source

Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]

, 2007
More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Annette Grüters, Buono, Christian Pitra, Claudia Stäubert, Cone, Haitina, Harald Brumm, Heike Biebermann, Hinney, Holger Römpler, Huszar, Jacobson, Kim, Larsen, Lubrano-Berthelier, Mergen, Patrick Tarnow, Ringholm, Salomon, Sangkuhl, Schioth, Schoneberg, Schoneberg, Schulz, Talbot, Tao, Tao, Tarnow, Thomas Gudermann, Torsten Schöneberg, Vaisse, VanLeeuwen, Xiang, Yeo, Yeo   +34 more
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The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to
Fatemeh Sabet Sarvestani, Mohammad Ali Zare, Forough saki, Farhad Koohpeyma, Ismail H. al-Abdullah, Negar Azarpira   +5 more
doaj   +1 more source

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +1 more source

Association of MC1R Variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study [PDF]

, 2010
<p><b>Background</b> Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes,
Affleck, P, Aguilera, P, Al\uf3s, L, Ancero, A, Arcangeli, F, Argu\ueds, P, Avril, Mf, Avril, Mf, Azizi, E, Badenas, C, Barrett, Jh, Battistuzzi, L, Bergman, W, Bergman, W, Bertazzi, Pa, BIANCHI-SCARR\uc0, G, Bianhi-Scarr\ue0, G, Bishop, Dt, Bishop, Dt, Borg, \uc5, BRESSAC-DE PAILLERETS, B, Bressac-de Paillerets, B, Bruno, W, Bruno, W., Butille, Ja, Calista, D, Calista, D, Campo, A, Capirossi, D, Carrera, C, Carrera, C, Castel, T, Cervera, R, Chan, M, Chaudru, V, Chaudru, V, Conill, C, Corda, E, Cuellar, F, de Lichy, M, Demenais, F, Duffy, Dl, Elder, D, Elder, De, Gabriel, D, Gargiulo, S, Ghiorzo, P, Ghiorzo, P., Gillanders, E, Gliori, S, Goldstein, Am, Goldstein, Am, Gonzalez, M, Gruis, N, Gruis, Na, H\uf6iom, V, H\uf6iom, V, Hansson, J, Hansson, J, Harbst, K, Harland, M, Harland, M, Harrison, J, Haynes, S, Hayward, Nk, Hayward, Nk, Hogg, D, Hogg, D, Holland, Ea, Holland, Ea., Iglesias, P, Iles, Mm, Ingvar, C, Ingvar, C, J\uf6nsson, G, Jeannin, P, Kanetsky, P, Kanetsky, Pa, Karpavicius, B, Kefford, Rf, Kukalizch, K, Landi, G, Landi, Mt, Landi, Mt, Lang, J, Lang, Jm, Leake, S, Lesueur, F, Lind\ue9n, D, Loo, Jc, M\ue5sb\ue4ck, A, Macgregor, S, Mack, T, Mackie, R, Mackie, Rm, Malvehy, J, Mann, Gj, Mann, Gj, Marti-Laborda, R, Martin, Ng, Maubec, E, Melanoma Genetics Consortium: Demenais, F, Mila, M, Ming, M, Ming, Me, Minghetti, P, Mitra, N, Mohamdi, H, Mohamdi, H, Montgomery, Gw, Nasti, S, NEWTON BISHOP JA,, Newton Bishop JA,, Nielsen, K, Njauw, Cj, Njauw, Cn, Ogbah, Z, Olsson, H, Olsson, H, Origone, P, Palmer, J, Palou, J, Parossian, S, Pastorino, L, Pastorino, L, Puig, S, Puig, S, Queirolo, P, RANDERSON-MOOR, J, Randerson-Moor, J, Ruffin, A, Rull, R, S\ue1nchez, M, Schmid, H, Stark, M, Taylor, Jc, Taylor, Y, Tesema, L, Tsao, H, Tsao, H, Tucker, Ma, Tucker, Ma, Tuominen, R, VAN BELLE, P, Van Belle, P, VAN DER VELDEN, P, van der Velden, P, van Mourik, L, van Nieuwpport FA,, Vidal-Sicart, S, Vilalta, A, Vilella, R, Whiteman, Dc, Whittaker, L, Yang, Xr, Yang, Xr   +155 more
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Melanocortin 1 Receptor Variants: Functional Role and Pigmentary Associations [PDF]

Photochemistry and Photobiology, 2011
AbstractThe significance of human cutaneous pigmentation lies in its protective role against sun‐induced DNA damage and photocarcinogenesis. Fair skin and red hair are characterized by a low eumelanin to pheomelanin ratio, and have been associated with increased risk of skin cancer.
Dessinioti, C., Antoniou, C., Katsambas, A., Stratigos, A.J.   +3 more
openaire   +3 more sources