Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland [PDF]
, 2011 The melanocortin-2-receptor (MC2R)/MC2R accessory protein (MRAP) complex is critical to the production of glucocorticoids from the adrenal cortex. Inactivating mutations in either MC2R or MRAP result in the clinical condition familial glucocorticoid ...
Chan, LF +4 more
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Feeding induced by cannabinoids is mediated independently of the melanocortin system. [PDF]
PLoS ONE, 2008 Cannabinoids, the active components of marijuana, stimulate appetite, and cannabinoid receptor-1 (CB1-R) antagonists suppress appetite and promote weight loss.
Puspha Sinnayah +9 more
doaj +1 more source
Modulation of social behavior by the agouti pigmentation gene [PDF]
, 2014 Agouti is a secreted neuropeptide that acts as an endogenous antagonist of melanocortin receptors. Mice and rats lacking agouti (called non-agouti) have dark fur due to a disinhibition of melanocortin signaling and pigment deposition in the hair follicle.
Carola V +5 more
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Association of single nucleotide polymorphism in melanocortin receptor gene with egg production traits in lohmann brown chickens [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017 Melanocortin receptor (MC4R) plays an important role in central melanocortin system and regulation of feed intake in birds. In this study the melanocortin gene (MC4R) was proposed as a candidate gene for egg production traits (yield and weight) in ...
Karim EL-SABROUT, Sarah AGGAG
doaj +1 more source
Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia [PDF]
, 2014 Open Access funded by Medical Research CouncilPeer reviewedPublisher ...
Alastair S. Garfield +28 more
core +1 more source
The effects of BMS-470539 on lipopolysaccharide-induced acute lung injury [PDF]
Acute and Critical Care, 2019 Background Overactivation of inflammatory cells, including macrophages and neutrophils, is associated with acute lung injury. BMS-470539 is a selective agonist of melanocortin 1 receptor, which triggers the inhibition of proinflammatory responses ...
Eun-A Jang +5 more
doaj +1 more source
Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177
Frontiers in Immunology, 2022 BackgroundMelanocortins are peptides endowed with anti-inflammatory and pro-resolving activities. Many of these effects are mediated by the Melanocortin receptor 1 (MC1) as reported in several experimental settings.
Jose Garrido-Mesa +7 more
doaj +1 more source
Endocrinologic Control of Men's Sexual Desire and Arousal/Erection [PDF]
, 2016 Several hormones and neurotransmitters orchestrate men's sexual response, including the appetitive (sexual desire) and consummative (arousal and penile erection) phases.
Aversa, Antonio +4 more
core +1 more source
Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
Nature Communications, 2019 Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit ...
Shuyang Chen +15 more
doaj +1 more source
Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]
, 2006 The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Acuna-Goycolea +41 more
core +4 more sources