Results 91 to 100 of about 44,230 (269)
The expression of the ACTH receptor
Brazilian Journal of Medical and Biological Research, 2000 Adrenal glucocorticoid secretion is regulated by adrenocorticotropic hormone (ACTH) acting through a specific cell membrane receptor (ACTH-R). The ACTH-R is a member of the G protein superfamily-coupled receptors and belongs to the subfamily of ...
L.L.K. Elias, A.J.L. Clark
doaj +1 more source
Selection on the Major Color Gene Melanocortin-1-Receptor Shaped the Evolution of the Melanocortin System Genes. [PDF]
, 2017 Modular genetic systems and networks have complex evolutionary histories shaped by selection acting on single genes as well as on their integrated function within the network. However, uncovering molecular coevolution requires the detection of coevolving
Alexandre Roulin +7 more
core +2 more sources
Journal of Small Animal Practice, EarlyView.This mini‐review describes the pathophysiology of the disrupted hypothalamic–pituitary–adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1‐1Δ in dogs and ABCB11930‐1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.
K. L. Mealey
wiley +1 more source
Cell Discovery, 2023 Members of the melanocortin receptor (MCR) family that recognize different melanocortin peptides mediate a broad spectrum of cellular processes including energy homeostasis, inflammation and skin pigmentation through five MCR subtypes (MC1R–MC5R).
Wenbo Feng +14 more
doaj +1 more source
Hypothalamic gene expression during voluntary hypophagia in the Sprague-Dawley rat on withdrawal of the palatable liquid diet, Ensure [PDF]
, 2014 Copyright © 2014 Elsevier Inc.
Archer, Zoe A +2 more
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Setmelanotide in Bardet‐Biedl Syndrome: A Case Report
Pediatric Dermatology, EarlyView.ABSTRACT Setmelanotide is a melanocortin‐4‐receptor agonist used for the treatment of hyperphagia in the genetic obesity syndrome Bardet‐Biedl. Presented is a case of diffuse hyperpigmentation in a patient treated with setmelanotide, which represents the most common side effect of this medication.
Shelby Smith +2 more
wiley +1 more source
Melanocortin receptors and their accessory proteins [PDF]
Molecular and Cellular Endocrinology, 2011 The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for their function.
Cooray, Sadani N., Clark, Adrian J.L.
openaire +3 more sources
Melanocortin receptors as novel effectors of macrophage responses in inflammation
Frontiers in Immunology, 2011 Macrophages have crucial functions in initiating the inflammatory reaction in a strict temporal and spatial manner to provide a ‘clear-up’ response required for resolution.
Hetal B Patel +3 more
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Binding, thermodynamics, and selectivity of a non-peptide antagonist to the melanocortin-4 receptor [PDF]
, 2018 The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design.
Clark, Timothy +5 more
core +2 more sources
Photochemistry and Photobiology, EarlyView.Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza +4 more
wiley +1 more source