Results 101 to 110 of about 34,268 (231)

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

The Clinical Phenotype and Genetic Analysis of Monogenic Non Syndromic Obesity Caused by MC4R Gene Variation

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
A novel MC4R mutation (c.185A > G) was identified in a 10‐year‐old girl with severe obesity and hyperinsulinemia. Retrospective analysis of 64 pediatric cases revealed that mutation location influences BMI, modulated by underlying disease status, demonstrating that the genotype–phenotype relationship in MC4R‐associated obesity is clinically context ...
Xin Li, Xiaotian Wang, Xin Liu, Shuping Wang, Wentao Yang   +4 more
wiley   +1 more source

The Synthetic Melanocortin Agonist NDP‐MSH Ameliorates THSD7A‐Associated Membranous Nephropathy in an Active Immunization Mouse Model

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Mingzhuo Zhang, Mengxuan Chen, Yan Ge, William Gunning, Rujun Gong   +4 more
wiley   +1 more source

Supraphysiological Glucocorticoid Doses and Pitfalls of Annual Biomarker Monitoring in Adults With CAH

Clinical Endocrinology, Volume 105, Issue 3, Page 360-362, September 2026.
Jakob Bolinder, Oskar Ragnarsson, Gudmundur Johansson   +2 more
wiley   +1 more source

Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology

, 2020
Nasrin N.A. Berruien, Caroline L. Smith
openalex   +2 more sources

7,3′,4′-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses α-Melanocyte-Stimulating Hormone-Induced Melanogenesis by Targeting Melanocortin 1 Receptor [PDF]

, 2020
Ji Hye Kim, Jae-Eun Lee, Tae‐Won Kim, Myung Hun Yeom, Jun Seong Park, Eric di Luccio, Hanyong Chen, Zigang Dong, Ki Won Lee, Nam Joo Kang   +9 more
openalex   +1 more source

Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors

, 2003
Chiara Mioni, Daniela Giuliani, Maria Michela Cainazzo, Sheila Leone, Carla Iannone, Carla Bazzani, Paolo Grieco, Ettore Novellino, Aldo Tomasi, Alfio Bertolini, Salvatore Guarini   +10 more
openalex   +2 more sources

Chronic Nicotine Consumption and Withdrawal Regulate Melanocortin Receptor, CRF, and CRF Receptor mRNA Levels in the Rat Brain

Brain Sciences
Alterations in the various neuropeptide systems in the mesocorticolimbic circuitry have been implicated in negative effects associated with drug withdrawal.
Oguz Gozen, Buket Aypar, Meliha Ozturk Bintepe, Fulya Tuzcu, Burcu Balkan, Ersin O. Koylu, Lutfiye Kanit, Aysegul Keser   +7 more
doaj   +1 more source

Long-Term Weight Outcome After Bariatric Surgery in Patients with Melanocortin-4 Receptor Gene Variants: a Case–Control Study of 105 Patients [PDF]

, 2022
Mellody I. Cooiman, Suzanne Alsters, Maëva Duquesnoy, Eric J. Hazebroek, Hanne J. Meijers-Heijboer, Harvinder Chahal, Johanne Le Beyec, Karine Clément, Hédi Soula, Alexandra I. F. Blakemore, Christine Poitou, Mieke M. van Haelst   +11 more
openalex   +1 more source

NGT: Generative AI with Synthesizability Guarantees Identifies Potent Inhibitors for a G-protein Associated Melanocortin Receptor in a Tera-scale vHTS Screen [PDF]

Saulo H. P. de Oliveira, Aryan Pedawi, Victor Kenyon, Henry van den Bedem   +3 more
openalex   +1 more source