Results 11 to 20 of about 92,933 (386)
BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation [PDF]
Nucleic Acids Research, 2017 Mutations in SOX10 cause neurocristopathies which display varying degrees of hypopigmentation. Using a sensitized mutagenesis screen, we identified Smarca4 as a modifier gene that exacerbates the phenotypic severity of Sox10 haplo-insufficient mice ...
Aras, S +12 more
core +2 more sources
Melanocytes, melanocyte stem cells, and melanoma stem cells [PDF]
Clinics in Dermatology, 2013 Melanocyte stem cells differ greatly from melanoma stem cells; the former provide pigmented cells during normal tissue homeostasis and repair, and the latter play an active role in a lethal form of cancer. These 2 cell types share several features and can be studied by similar methods.
Joseph B. Mascarenhas +2 more
openaire +4 more sources
Vitiligo and the melanocyte reservoir
Indian Journal of Dermatology, 2009 Repigmentation of vitiligo depends on available melanocytes from three possible sources: from the hair follicle unit which is the main provider of pigment cells, from the border of vitiligo lesions, and from unaffected melanocytes within depigmented areas; pigment cells at these locations originate a perifollicular, border spreading and a diffuse ...
Falabella Rafael
openaire +5 more sources
Dedifferentiation maintains melanocyte stem cells in a dynamic niche
Nature, 2023 Local microenvironmental cues modulate melanocyte stem cells, which control hair pigmentation, to enter different differentiation states, shifting between hair follicle stem cell and transit-amplifying compartments, a process that is different to other ...
Qi Sun +12 more
semanticscholar +1 more source
eLife, 2023 Tissue-resident stem and progenitor cells are present in many adult organs, where they are important for organ homeostasis and repair in response to injury. However, the signals that activate these cells and the mechanisms governing how these cells renew
William Tyler Frantz +5 more
doaj +1 more source
Human melanocyte development and melanoma dedifferentiation at single-cell resolution
Nature Cell Biology, 2021 In humans, epidermal melanocytes are responsible for skin pigmentation, defence against ultraviolet radiation and the deadliest common skin cancer, melanoma. Although there is substantial overlap in melanocyte development pathways between different model
R. Belote +10 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2023 Melanoma is the deadliest form of skin cancer and develops from the melanocytes that are responsible for the pigmentation of the skin. The skin is also a highly regenerative organ, harboring a pool of undifferentiated melanocyte stem cells that ...
Esra Katkat +10 more
doaj +1 more source
Pigment Cell & Melanoma Research, 2021 Human epidermal melanocytes play a central role in sensing the environment and protecting the skin from the drastic effects of solar ultraviolet radiation and other environmental toxins or inflammatory agents.
Parth R Upadhyay +2 more
semanticscholar +1 more source
A Study of Normal Epidermal Melanocyte Distribution
International Journal of Dermatology and Venerology, 2021 . Objective:. To elucidate the epidermal melanocyte distribution according to sex, age, and body part with the goal of providing benchmark data for the diagnosis and therapeutic effect evaluation of pigmentary skin diseases. Methods:.
Kai-Lv Sun +4 more
doaj +1 more source
The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans. [PDF]
PLoS ONE, 2010 BACKGROUND: The neuropeptide alpha-melanocyte-stimulating hormone is well known as a mediator of skin pigmentation. More recently, it has been shown that alpha-melanocyte-stimulating hormone also plays pivotal roles in energy homeostasis, sexual function,
Karin Loser +10 more
doaj +1 more source