Molecular and cellular pathogenesis of melanoma initiation and progression [PDF]
, 2013 Melanoma is a malignant tumour of melanocytes, which can spread to other organs of the body resulting in severe and/or lethal malignancies. Melanocytes are pigment producing cells found in deep layer of the epidermis and are originated from melanocytes ...
Regad, T
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Vitiligo and autoimmune thyroid disorders [PDF]
, 2017 Vitiligo represents the most common cause of acquired skin, hair and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte ...
Baldini, Enke +10 more
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Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation [PDF]
, 2013 Fascins, a family of actin-bundling proteins, are expressed in a spatially and temporally restricted manner during development and often in cancer.
Ackermann +52 more
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The biology of melanocyte and melanocyte stem cell [PDF]
Acta Biochimica et Biophysica Sinica, 2014 The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations.
openaire +3 more sources
Frontiers in Neuroanatomy, 2022 The eye, the pineal complex and the skin are important photosensitive organs. The African clawed frog, Xenopus laevis, senses light from the environment and adjusts skin color accordingly.
Gabriel E. Bertolesi +4 more
doaj +1 more source
Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]
, 2016 The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H. +5 more
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Recurrent laryngeal neuropathy secondary to nerve compression by melanomas - case report [PDF]
Arquivo Brasileiro de Medicina Veterinária e ZootecniaRecurrent laryngeal neuropathy (RLN) etiology can be acquired, iatrogenic or idiopathic. There are no previous reports of RLN caused by recurrent laryngeal nerve compression by melanomas.
J.M. Alonso +7 more
doaj +2 more sources
Gnaq and Gna11 in the Endothelin signaling pathway and melanoma
Frontiers in Genetics, 2016 In this article, we first briefly outline the function of G protein coupled receptors in cancer, and then specifically examine the roles of the seven transmembrane G protein coupled Endothelin B receptor (Ednrb) and the G proteins, GNAQ and GNA11, in ...
Oscar eUrtatiz +1 more
doaj +1 more source
High correlation between skin color based on CIELAB color space, epidermal melanocyte ratio, and melanocyte melanin content [PDF]
PeerJ, 2018 Background To treat skin color disorders, such as vitiligo or burns, melanocytes are transplanted for tissue regeneration. However, melanocyte distribution in the human body varies with age and location, making it difficult to select the optimal donor ...
Wen-Shyan Huang +9 more
doaj +2 more sources
In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]
, 2015 Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B. +12 more
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