Results 31 to 40 of about 76,131 (358)

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]

, 2015
Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B., Haferkamp, S., Hufnagel, A.L., Kneitz, S., Leikam, C., Meierjohann, S., Murphy, D.J., Mühling, B., Nanda, I., Otto, C., Schartl, M., Schmid, M., Wagner, T.U.   +12 more
core   +2 more sources

Avian Pigment Pattern Formation: Developmental Control of Macro- (Across the Body) and Micro- (Within a Feather) Level of Pigment Patterns

Frontiers in Cell and Developmental Biology, 2020
Animal color patterns are of interest to many fields, such as developmental biology, evolutionary biology, ethology, mathematical biology, bio-mimetics, etc. The skin provides easy access to experimentation and analysis enabling the developmental pigment
Masafumi Inaba, Cheng-Ming Chuong
doaj   +1 more source

Vitiligo and autoimmune thyroid disorders [PDF]

, 2017
Vitiligo represents the most common cause of acquired skin, hair and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte ...
Baldini, Enke, Carbotta, Giovanni, Catania, Antonio, D'Armiento, Eleonora, Odorisio, Teresa, Persechino, Severino, Pironi, Daniele, Rendina, Roberta, Sorrenti, Salvatore, Tartaglia, Francesco, Ulisse, Salvatore   +10 more
core   +2 more sources

The biology of melanocyte and melanocyte stem cell [PDF]

Acta Biochimica et Biophysica Sinica, 2014
The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations.
openaire   +3 more sources

Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]

, 2018
Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar, Detering, Lisa, Liu, Yongjian, Luehmann, Hannah, Pang, Bo, Sultan, Deborah, Xia, Younan, Yang, Miaoxin, Zhao, Yongfeng   +8 more
core   +2 more sources

A Simple Drug Delivery System for Platelet-Derived Bioactive Molecules, to Improve Melanocyte Stimulation in Vitiligo Treatment

Nanomaterials, 2020
Vitiligo is the most common depigmentation disorder of the skin. Currently, its therapy focuses on the halting of the immune response and stimulation of the regenerative processes, leading to the restoration of normal melanocyte function.
Karolina Vocetkova, Vera Sovkova, Matej Buzgo, Vera Lukasova, Radek Divin, Michala Rampichova, Pavel Blazek, Tomas Zikmund, Jozef Kaiser, Zdenek Karpisek, Evzen Amler, Eva Filova   +11 more
doaj   +1 more source

Melanoacanthoma of Pinna-Treated with Skin Grafting: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2018
Melanoacanthoma is a very rare cutaneous lesion and it is considered to be a benign neoplasm, which is composed of large dendritic melanocytes and epidermal keratinocytes.
Santosh Uttarkar Pandurangarao, Sridurga Janarthanan, Aravind Darga Ramachandra   +2 more
doaj   +1 more source

Developmentally regulated expression of integrin alpha-6 distinguishes neural crest derivatives in the skin

Frontiers in Cell and Developmental Biology, 2023
Neural crest-derived cells play essential roles in skin function and homeostasis. However, how they interact with environmental cues and differentiate into functional skin cells remains unclear.
Shize Ma, Shize Ma, Xiu Li, Xiu Li, Rui Cao, Rui Cao, Guoqin Zhan, Guoqin Zhan, Xin Fu, Xin Fu, Ran Xiao, Ran Xiao, Zhigang Yang, Zhigang Yang   +13 more
doaj   +1 more source

Unraveling Vitiligo: From Immune Mechanisms to Promising Therapeutic Strategies [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Vitiligo is a dermatological condition affecting 1% of the global population, characterized by the loss of skin pigmentation. It appears in two main forms: nonsegmental (symmetrical depigmentation) and segmental (localized depigmentation).
Artur Kovenskiy, Nurlubek Katkenov, Zhussipbek Mukatayev, Almagul Kushugulova   +3 more
doaj   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
core   +1 more source