Results 61 to 70 of about 92,933 (386)

Aging of Melanocytes

Journal of Investigative Dermatology, 1979
Choroidal melanocytes of the eyes of postnatal animals are classified as postmitotic terminally differentiated cells. They have specific granules, the melanosomes, which undergo changes qualitatively and quantitatively correlated to the animal's increasing age.
openaire   +3 more sources

Gnaq and Gna11 in the Endothelin signaling pathway and melanoma

Frontiers in Genetics, 2016
In this article, we first briefly outline the function of G protein coupled receptors in cancer, and then specifically examine the roles of the seven transmembrane G protein coupled Endothelin B receptor (Ednrb) and the G proteins, GNAQ and GNA11, in ...
Oscar eUrtatiz, Catherine D Van Raamsdonk   +1 more
doaj   +1 more source

Dysregulated autophagy increased melanocyte sensitivity to H2O2-induced oxidative stress in vitiligo

Scientific Reports, 2017
In vitiligo, melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state generated during melanin synthesis and to the genetic antioxidant defects.
Yuanmin He, Shuli Li, Weigang Zhang, W. Dai, Tingting Cui, Gang Wang, T. Gao, Chunying Li   +7 more
semanticscholar   +1 more source

Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling [PDF]

, 2015
Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61.
Adams, P.D., Al-Olabi, L., Blyth, K., Brock, C., Chanudet, E., Chen, S.-C., Holmes, W.M., King, A., Kinsler, V.A., Lambie, W., McGregor, F., Mullin, J.M., Nixon, C., Paine, S., Pawlikowski, J.S., Richmond, A., Wu, H.   +16 more
core   +2 more sources

Recurrent laryngeal neuropathy secondary to nerve compression by melanomas - case report [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Recurrent laryngeal neuropathy (RLN) etiology can be acquired, iatrogenic or idiopathic. There are no previous reports of RLN caused by recurrent laryngeal nerve compression by melanomas.
J.M. Alonso, G.S. Rosa, A. Hataka, C.A. Hussni, M.L. Conceição, M.J. Watanabe, C.A. Rodrigues, A.L.G. Alves   +7 more
doaj   +2 more sources

Exosomes released by keratinocytes modulate melanocyte pigmentation

Nature Communications, 2015
Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions.
Alessandra Lo Cicero, C. Delevoye, Floriane Gilles-Marsens, D. Loew, F. Dingli, C. Guere, Nathalie André, K. Vié, Guillaume van Niel, G. Raposo   +9 more
semanticscholar   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
core   +1 more source

Biology of melanocytes in mammals

Frontiers in Cell and Developmental Biology, 2023
Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for producing pigments and possessing a dendritic morphology. These cells migrate to the epidermis and follicles, contributing to skin and hair pigmentation during embryonic development.
Ying-Zhe Cui, Xiao-Yong Man
openaire   +3 more sources

Melanogenesis and hypopigmentation: The case of vitiligo

Indian Journal of Dermatology, 2022
Melanocytes are highly specialized dendritic cells that synthesize and store melanin in subcellular organelles called melanosomes, before transfer to keratinocytes.
M Pilar Vinardell, Adriana Solange Maddaleno, Montserrat Mitjans   +2 more
doaj   +1 more source

Melanoma Inhibitory Activity (MIA) Is Able to Induce Vitiligo-Like Depigmentation in an in vivo Mouse Model by Direct Injection in the Tail

Frontiers in Medicine, 2020
In the complex pathogenesis of vitiligo, the exact mechanism of the dermatosis is still to be clarified. We previously demonstrated that a protein called melanoma inhibitory activity (MIA) is present in non-segmental vitiligo skin and seems to cause the ...
Matteo Bordignon, Roberto Luisetto, Maria Luisa Valente, Marny Fedrigo, Chiara Castellani, Annalisa Angelini, Mauro Alaibac   +6 more
doaj   +1 more source