Molecular Ecology Resources, EarlyView.ABSTRACT Genomic incompatibilities and differential ecological adaptation are thought to be fundamental mechanisms of speciation. In this study, we generated a chromosome‐scale reference genome and annotation for Gopherus morafkai , the Sonoran Desert tortoise, and conducted a detailed analysis of genes under positive selection with its sister species,
Sarah M. Baty +6 more
wiley +1 more source
Pathology Report Generation and Multimodal Representation Learning for Cutaneous Melanocytic Lesions [PDF]
arXivMillions of melanocytic skin lesions are examined by pathologists each year, the majority of which concern common nevi (i.e., ordinary moles). While most of these lesions can be diagnosed in seconds, writing the corresponding pathology report is much more time-consuming.
arxiv
Senescent fibroblasts can drive melanoma initiation and progression [PDF]
arXiv, 2013 Skin is one of the largest human organ systems whose primary purpose is the protection of deeper tissues. As such, the skin must maintain a homeostatic balance in the face of many microenvironmental and genetic perturbations. At its simplest, skin homeostasis is maintained by the balance between skin cell growth and death such that skin architecture is
arxiv
Studies on pituitary polypeptide hormones. 1. The structure of β-melanocyte-stimulating hormone from pig pituitary glands [PDF]
, 1959 J. Ieuan Harris, P. Roos
openalex +1 more source
Origins of the avian neural crest: the role of neural plate-epidermal interactions [PDF]
, 1995 We have investigated the lineage and tissue interactions that result in avian neural crest cell formation from the ectoderm. Presumptive neural plate was grafted adjacent to non-neural ectoderm in whole embryo culture to examine the role of tissue ...
Bronner-Fraser, Marianne +1 more
core
Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging
Aging Cell, EarlyView.Age‐related increases in IGF‐1 expression in the skin accelerate stem cell exhaustion and senescence by impairing SIRT1 function, ultimately driving hair follicle aging. Conversely, activating SIRT1, clearing senescent cells, or adopting dietary restriction can mitigate excessive IGF‐1 signaling and provide a promising strategy to rejuvenate hair ...
Yang Wang +22 more
wiley +1 more source
Effectiveness of Two Phytochemicals, P-Coumaric Acid and Quercetin in Reducing the Melanin Content of Pigmented Gingival Tissue: An Ex-vivo Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Pigmented gingiva is an aesthetic concern for many individuals. Various treatment modalities have been developed to address this condition, but each carries certain disadvantages.
Shubhangi Behl +2 more
doaj +1 more source
Aging Cell, EarlyView.Expression of HIRA in embryonic melanoblasts is required for proper epigenetic programing and lineage differentiation. Although HIRA deficiency results in a mild phenotype at birth and young adulthood, the melanocytic lineage is sensitive to proliferative challenge, prone to loss of stem cells and dramatically accelerated hair greying in later life ...
Farah Jaber‐Hijazi +20 more
wiley +1 more source
Differentiation of cultured hair follicle neural crest stem cells into functional melanocytes
HeliyonMany autologous melanocytes are required for surgical treatment of depigmentation diseases such as vitiligo. However, primary cultured melanocytes have a limited number of in vitro passages.
Hongjuan Wang +7 more
doaj
The experimental generation of antibodies to alpha-melanocyte stimulating hormone and adrenocorticotropic hormone. [PDF]
, 1965 Joseph McGuire +3 more
openalex +1 more source