Results 71 to 80 of about 48,156 (309)

Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship

Frontiers in Oncology, 2022
Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet radiation and other environmental stressors. It is produced by the enzymatic transformation of L-tyrosine to dopaquinone and subsequent chemical and ...
Radomir M. Slominski, Tadeusz Sarna, Przemysław M. Płonka, Chander Raman, Anna A. Brożyna, Andrzej T. Slominski, Andrzej T. Slominski   +6 more
doaj   +1 more source

Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes

Advanced Science, EarlyView.
This study demonstrates that SLC16A10 plays a crucial role in psoriasis pathogenesis through arachidonic acid metabolism regulation in keratinocytes. Using multi‐omics analysis and experimental validation, researchers identify SLC16A10 as both a diagnostic biomarker and therapeutic target.
Jingyuan Yang, Yixuan Chen, Bowei Li, Shuang Wu, Hang Liang, Xingyue Yang, Xiaozhen Li, Ping Sun, Guangjin Guo, Ting Li, Yuying Jia, Haijiao Li, Mengqi Bai, Jie Xu, Zhijie Liu, Wei Liu, Xiangkang Jiang, Hong Cai   +17 more
wiley   +1 more source

Cytogenetics of Melanocytic Tumors

Journal of Investigative Dermatology, 1993
Chromosome studies of human melanocytic tumors have demonstrated non-random karyotypic abnormalities of chromosomes 1, 6, 7, 9, and 10. These visible genetic alterations may provide clues to the location of oncogenes and suppressor genes involved in the development of lesions from benign nervus to metastatic melanoma, and to the mechanisms by which the
Annette H. Parmiter, Peter C. Nowell
openaire   +3 more sources

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Evans Medicine [PDF]

, 1988
Newsletter of the Evans Memorial Department of Clinical Research and Preventive Medicine at University ...
University Hospital, Evans Memorial Department of Clinical Research and Preventive Medicine
core  

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

Origins of the avian neural crest: the role of neural plate-epidermal interactions [PDF]

, 1995
We have investigated the lineage and tissue interactions that result in avian neural crest cell formation from the ectoderm. Presumptive neural plate was grafted adjacent to non-neural ectoderm in whole embryo culture to examine the role of tissue ...
Bronner-Fraser, Marianne, Selleck, Mark A. J.   +1 more
core  

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source

USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF

Advanced Science, EarlyView.
USP45 acts as a melanoma suppressor by stabilizing MRGPRF, which weakens the PI3K/AKT pathway, suppresses tumor growth, and reduces melanoma cell migration and invasion. Abstract Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway.
Wancong Zhang, Liyun Chen, Jing Zhao, Aiwei Ma, Wenqi Shi, Yiwen Zhang, Zixuan Tang, Jiarui Guo, Zaihua Xu, Jianda Zhou, Shijie Tang   +10 more
wiley   +1 more source

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. [PDF]

, 2013
The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized. Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated.
Akslen, Albino, Anissa Chikh, Antonio Costanzo, Arima, Arnoult, Avery-Kiejda, Avery-Kiejda, Azzola, Bae, Baisden, Bardeesy, Belmar-Lopez, Benchimol, Bourne, Brinck, Burford, Bártek, Catherine A. Harwood, Chan, Charlotte M. Proby, Chehab, Chipuk, Chipuk, Choi, Colombari, Daniele Bergamaschi, David Mesher, Dellavalle, Dhillon, Di Como, Dotto, el-Deiry, Fenouille, Flores, Flores, Francesca Moretti, Fukushima, Gembarska, Giovanna Chiorino, Glusac, Gomez-Monterrey, Gressner, Hameed, Harmes, Hibi, Hirao, Hocker, Hoek, Houben, Hu, Hussein, Ikawa, Irene M. Leigh, Jacobs, Ji, Kakudo, Kanner, Kanoko, Karst, Katoh, Keyes, Kilic, Knopf, Koga, Koster, Kulesz-Martin, Lassam, Leverrier, Li, Liefer, Little, MacPartlin, Mancini, Mangiulli, Manuela Graf, Marchenko, Marchini, Maria Scatolini, Massion, Matsuoka, McGregor, Merlino, Michaelis, Mihara, Mills, Moll, Morgan, Mundt, Muthusamy, Müller, Narahashi, Nemajerova, Oda, Okada, Osada, Paolo Sanza’, Perez-Losada, Petitjean, Polsky, Prince, Reis-Filho, Reis-Filho, Ribeiro-Silva, Riley, Rino Cerio, Rocca, Rocco, Rubeta N. Matin, Sakiz, Sansome, Sato, Satyamoorthy, Scatolini, Schilling, Seitz, Senoo, Senoo, Serber, Shieh, Shields, Smalley, Sparrow, Stephanie Law Pak Chong, Stretch, Suh, Tokuyasu, Tuve, Valentina Senatore, Vance, Verhaegen, Walerych, Walerych, Weiss, Westfall, Whitesell, Wäster, Yamamoto, Yamamoto, Yang, Yang, Yaziji, Zangen, Zerp   +143 more
core   +1 more source