The role of gene duplication and unconstrained selective pressures in the melanopsin gene family evolution and vertebrate circadian rhythm regulation. [PDF]
PLoS ONE, 2012 Melanopsin is a photosensitive cell protein involved in regulating circadian rhythms and other non-visual responses to light. The melanopsin gene family is represented by two paralogs, OPN4x and OPN4m, which originated through gene duplication early in ...
Rui Borges +5 more
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Melanopsin-mediated image statistics from natural and human-made environments [PDF]
Scientific ReportsMelanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) play a critical role in regulating physiological and behavioral responses to light.
Pablo A. Barrionuevo +1 more
doaj +2 more sources
Melanopsin and Cone Photoreceptor Inputs to the Afferent Pupil Light Response [PDF]
Frontiers in Neurology, 2019 Background: Retinal photoreceptors provide the main stage in the mammalian eye for regulating the retinal illumination through changes in pupil diameter, with a small population of melanopsin-expressing intrinsically photosensitive retinal ganglion cells
Andrew J. Zele +7 more
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Pupil responses to melanopsin-isolating stimuli as a potential diagnostic biomarker for glaucoma. [PDF]
PLoS ONEPurposeTo test whether differences in pupil responses to melanopsin-isolating spectral stimuli in glaucoma may be useful as a diagnostic biomarker.MethodsSpectral stimuli were presented to 20 glaucoma and 15 age-similar healthy control participants ...
Jonathan Denniss +3 more
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Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitro [PDF]
npj Biological Timing and SleepThe retinal photopigment melanopsin is also expressed in subcutaneous white adipose tissue (scWAT). Through melanopsin, light can modulate scWAT metabolism, but its impact on circadian phase is unclear.
Anna Edmondson +2 more
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Molecular basis underlying the specificity of an antagonist AA92593 for mammalian melanopsins. [PDF]
J Biol ChemObayashi K +4 more
europepmc +2 more sources
Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health [PDF]
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease MonitoringINTRODUCTION Melanopsin is a photopigment with roles in mediating sleep and circadian‐related processes, which are often disrupted in Alzheimer's disease (AD). Melanopsin also impacts cognition and synaptogenesis. This study investigated the associations
Ayeisha Milligan Armstrong +10 more
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Daylights with high melanopsin stimulation appear reddish in fovea and greenish in periphery
PLoS ONE, 2023 Melanopsin reportedly contributes to brightness and color appearance in photopic vision in addition to cone photoreceptor cells. However, the relationship between the contribution of melanopsin to color appearance and retinal location is unclear. Herein,
Hirokuni Higashi, Katsunori Okajima
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Melanopsin-derived visual responses under light adapted conditions in the mouse dLGN. [PDF]
PLoS ONE, 2015 A direct projection from melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) reaches the primary visual thalamus (dorsal lateral geniculate nucleus; dLGN).
Katherine E Davis +4 more
doaj +1 more source
Distribution of mammalian-like melanopsin in cyclostome retinas exhibiting a different extent of visual functions. [PDF]
PLoS ONE, 2014 Mammals contain 1 melanopsin (Opn4) gene that is expressed in a subset of retinal ganglion cells to serve as a photopigment involved in non-image-forming vision such as photoentrainment of circadian rhythms.
Lanfang Sun +6 more
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