Results 11 to 20 of about 11,542 (237)
The multistable melanopsins of mammals
Frontiers in Ophthalmology, 2023 Melanopsin is a light-activated G protein coupled receptor that is expressed widely across phylogeny. In mammals, melanopsin is found in intrinsically photosensitive retinal ganglion cells (ipRGCs), which are especially important for “non-image” visual ...
Alan J. Emanuel, Michael Tri H. Do
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β-Arrestin-dependent deactivation of mouse melanopsin. [PDF]
PLoS ONE, 2014 In mammals, the expression of the unusual visual pigment, melanopsin, is restricted to a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling regulate numerous non-visual functions including sleep, circadian ...
Evan G Cameron, Phyllis R Robinson
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Evolution of melanopsin photoreceptors: discovery and characterization of a new melanopsin in nonmammalian vertebrates. [PDF]
PLoS Biology, 2006 In mammals, the melanopsin gene (Opn4) encodes a sensory photopigment that underpins newly discovered inner retinal photoreceptors. Since its first discovery in Xenopus laevis and subsequent description in humans and mice, melanopsin genes have been ...
James Bellingham +9 more
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PLoS Biology, 2006 A new melanopsin gene, identified in fish, bird, and amphibian genomes, is the true ortholog of the melanopsin gene previously described in mammals.
James Bellingham +9 more
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Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and calcitonin gene-related peptide sensitization. [PDF]
HeadacheAbstract Objective The aim of this study was to determine the photoreceptor basis of light avoidance in mice and assess the effect of CGRP sensitization on this behavior. Background Prior studies have suggested that photophobia is mediated by a subset of retinal ganglion cells (RGCs) that contain melanopsin, making them intrinsically photosensitive ...
Kaiser EA +3 more
europepmc +2 more sources
Pinopsin Regulates Melatonin Production and Daily Locomotor Activity: Functional Insights From Gene-Edited Xenopus Tadpoles. [PDF]
J Pineal ResABSTRACT Circadian rhythm alignment depends on environmental light detection via opsins. Pinopsin, originally identified in the pineal organ of birds and later in amphibian pineal complex and eyes, may play a role in this process, though its function has not been genetically tested.
Heshami N +4 more
europepmc +2 more sources
Melanopsin phototransduction: beyond canonical cascades [PDF]
Journal of Experimental Biology, 2021 ABSTRACT Melanopsin is a visual pigment that is expressed in a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs). It is involved in regulating non-image forming visual behaviors, such as circadian photoentrainment and the pupillary light reflex, while also playing a role in many aspects of image-forming vision,
Ely Contreras +3 more
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Current Biology, 2002 What are opsins? Opsins are generally considered members of the superfamily of G-protein coupled receptors. But not all opsins activate a G-protein. Their distinguishing features are a 7 transmembrane α-helical structure, and an ability to bind a vitamin A chromophore, retinaldehyde, using a lysine in the 7th α-helix.
Foster, Russell, Bellingham, James
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Phosphorylation of mouse melanopsin by protein kinase A. [PDF]
PLoS ONE, 2012 The visual pigment melanopsin is expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) in the mammalian retina, where it is involved in non-image forming light responses including circadian photoentrainment, pupil constriction ...
Joseph R Blasic +2 more
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The neurobiology of circadian rhythms [PDF]
, 2009 Purpose of review There is growing awareness of the importance of circadian rhythmicity in various research fields. Exciting developments are ongoing in the field of circadian neurobiology linked to sleep, food intake, and memory.
Boersma, Gretha J., +2 more
core +9 more sources