Human melanopsin-AAV2/8 transfection to retina transiently restores visual function in rd1 mice [PDF]
International Journal of Ophthalmology, 2016 AIM: To explore whether ectopic expression of human melanopsin can effectively and safely restore visual function in rd1 mice. METHODS: Hematoxylin-eosin staining of retinal sections from rd1 mice was used to detect the thickness of the outer nuclear ...
Ming-Ming Liu +5 more
doaj +1 more source
Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms. [PDF]
PLoS ONE, 2008 Non-image related responses to light, such as the synchronization of circadian rhythms to the day/night cycle, are mediated by classical rod/cone photoreceptors and by a small subset of retinal ganglion cells that are intrinsically photosensitive ...
Didem Göz +5 more
doaj +1 more source
Melanopsin enhances image persistence
Current Biology, 2023 Contributions of the inner retinal photopigment melanopsin to human visual perception are incompletely understood. Here, we use a four-primary display to produce stimuli differing in melanopsin versus cone contrast in psychophysical paradigms in eight subjects with normal color vision.
Tom Woelders +2 more
openaire +2 more sources
G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells. [PDF]
PLoS ONE, 2015 Phosphorylation is a primary modulator of mammalian G-protein coupled receptor (GPCR) activity. The GPCR melanopsin is the photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs) in the mammalian retina. Recent evidence from in vitro
Timothy J Sexton, Russell N Van Gelder
doaj +1 more source
Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception. [PDF]
PLoS ONE, 2010 Melanopsin photoreception plays a vital role in irradiance detection for non-image forming responses to light. However, little is known about the involvement of melanopsin in emotional processing of luminance.
Ma'ayan Semo +8 more
doaj +1 more source
Spectral Tuning in Mammalian Melanopsins. [PDF]
Mol Biol EvolAbstract Melanopsin is a light-sensitive G-protein coupled receptor responsible for essential visual and non-visual light-mediated behaviors in mammals. Human melanopsin shows maximal sensitivity (λmax) in the blue region of the spectrum (∼480 nm), and available evidence suggests that this spectral sensitivity may be retained across ...
McDowell RJ +3 more
europepmc +3 more sources
Loss of gq/11 genes does not abolish melanopsin phototransduction. [PDF]
PLoS ONE, 2014 In mammals, a subset of retinal ganglion cells (RGCs) expresses the photopigment melanopsin, which renders them intrinsically photosensitive (ipRGCs). These ipRGCs mediate various non-image-forming visual functions such as circadian photoentrainment and ...
Kylie S Chew +4 more
doaj +1 more source
Melanopsin expression in the cornea [PDF]
Visual Neuroscience, 2018 AbstractA unique class of intrinsically photosensitive retinal ganglion cells in mammalian retinae has been recently discovered and characterized. These neurons can generate visual signals in the absence of inputs from rods and cones, the conventional photoreceptors in the visual system. These light sensitive ganglion cells (mRGCs) express the non-rod,
Delwig, Anton +11 more
openaire +6 more sources
From blue light to clock genes in zebrafish ZEM-2S cells. [PDF]
PLoS ONE, 2014 Melanopsin has been implicated in the mammalian photoentrainment by blue light. This photopigment, which maximally absorbs light at wavelengths between 470 and 480 nm depending on the species, is found in the retina of all classes of vertebrates so far ...
Bruno C R Ramos +4 more
doaj +1 more source
Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always [PDF]
, 2017 Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle.
Carelli, Valerio +7 more
core +1 more source