EVOLUTION OF THE CIRCADIAN CLOCK IN EXTREME ENVIRONMENT: LESSONS FROM CAVEFISH. [PDF]
, 2010 Evolution has been strongly influenced by the daily cycles of temperature and light imposed by the rotation of the Earth. Fascinating demonstrations of this are seen in extreme environments such as caves where some animals have remained completely ...
Cavallari, Nicola
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Lighting as a Circadian Rhythm-Entraining and Alertness-Enhancing Stimulus in the Submarine Environment [PDF]
, 2006 The human brain can only accommodate a circadian rhythm that closely follows 24 hours. Thus, for a work schedule to meet the brain’s hard-wired requirement, it must employ a 24 hour-based program.
Bullough, J. D. +4 more
core +1 more source
Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. [PDF]
PLoS ONE, 2008 Rod/cone photoreceptors of the outer retina and the melanopsin-expressing retinal ganglion cells (mRGCs) of the inner retina mediate non-image forming visual responses including entrainment of the circadian clock to the ambient light, the pupillary light
Megumi Hatori +9 more
doaj +1 more source
Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls. [PDF]
, 2015 This study examined the effect of optic nerve disease, hence retinal ganglion cell loss, on non-visual functions related to melanopsin signalling. Test subjects were patients with bilateral visual loss and optic atrophy from either hereditary optic ...
Collomb, S. +3 more
core +1 more source
Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases
Annals of Neurology, Volume 98, Issue 6, Page 1178-1195, December 2025.[Color figure can be viewed at www.annalsofneurology.org] Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and ...
Nico J. Diederich +20 more
wiley +1 more source
Acta Neuropathologica Communications, 2018 Parkinson’s disease (PD) patients often suffer from non-motor symptoms like sleep dysregulation, mood disturbances or circadian rhythms dysfunction. The melanopsin-containing retinal ganglion cells are involved in the control and regulation of these ...
Isabel Ortuño-Lizarán +6 more
doaj +1 more source
Acta Ophthalmologica, Volume 103, Issue 8, Page 864-878, December 2025.Abstract This meta‐analysis investigates the effectiveness of outdoor activities in reducing the onset of myopia in children and adolescents by analysing changes in axial elongation and spherical equivalent refractive error. Following PRISMA guidelines and registered in PROSPERO (CRD42024592971), the study included randomized controlled trials (RCTs ...
Clara Martinez‐Perez +4 more
wiley +1 more source
Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging
Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.Abstract Recent studies have highlighted retinal optical coherence tomography (OCT) imaging as a promising biomarker for the early detection of Alzheimer's disease (AD). This review connects AD brain pathology – particularly amyloid beta (Aβ), tau, and vascular changes – with corresponding retinal changes.
M. Amin Banihashemi +9 more
wiley +1 more source
Multimodal investigation of melanopsin retinal ganglion cells in Alzheimer's disease [PDF]
, 2023 Chiara La Morgia +21 more
openalex +1 more source
Reported light in the sleep environment: enhancement of the sleep diary. [PDF]
, 2019 BackgroundLight is the primary synchronizing cue for the circadian timing system, capable of exerting robust physiological effects, even with very dim and/or brief photic exposure. Mammals, including humans, are particularly susceptible to light at night.
Ancoli-Israel, Sonia +4 more
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