Results 91 to 100 of about 227,315 (399)

Comparative Pharmacokinetics of Sustained-Release versus Immediate-Release Melatonin Capsules in Fasting Healthy Adults: A Randomized, Open-Label, Cross-Over Study

open access: yesPharmaceutics
Background: Exogenous melatonin, a nutraceutical for maintaining a healthy sleep–wake cycle and managing sleep disorders, requires large, repeated doses due to its low bioavailability and short half-life.
Shefali Thanawala   +2 more
doaj   +1 more source

Behavioral changes in the brown planthopper, Nilaparvata lugens, mediated by melatonin

open access: yesCABI Agriculture and Bioscience, 2021
Background Melatonin has been proved to exist and play importance roles in rice plant, such as biosynthesis and resistance. However, little is known about the function of melatonin in its monophagous pest, the brown planthopper. Methods In this study, we
Longqing Shi   +5 more
doaj   +1 more source

Melatonin inhibits HCC progression through regulating the alternative splicing of NEMO

open access: yesFrontiers in Pharmacology, 2022
Hepatocellular carcinoma (HCC) is one of the most common primary cancers with limited therapeutic options. Melatonin, a neuroendocrine hormone produced primarily by the pineal gland, demonstrates an anti-cancer effect on a myriad of cancers including HCC.
Lu Bai   +11 more
doaj   +1 more source

Melatonin and epilepsy [PDF]

open access: yesArchives of Disease in Childhood, 2005
There have been conflicting reports of the effects on seizure control of prescribing melatonin for people with epilepsy.1–4 We undertook a retrospective before-and-after observational study of 13 young people prescribed melatonin for sleep disturbances at the David Lewis Centre, a residential school for children and young adults with severe epilepsy ...
M Huyton, Cheryl A Jones, D Hindley
openaire   +3 more sources

Melatonin and Epilepsy [PDF]

open access: yesFolia Medica, 2021
Epilepsy is a chronic neurological disease with recurrent seizures. Its incidence, the social and psychological aspects of epilepsy-associated stigmatization in society, the medical risk of severe seizures, and the challenges in treatment confirm its medical and social significance.
openaire   +3 more sources

Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong   +7 more
wiley   +1 more source

PENGARUH PEMBERIAN MELATONIN TERHADAP JUMLAH LEUKOSIT PADA TIKUS WISTAR MODEL SEPSIS [PDF]

open access: yes, 2016
Background : Melatonin was a free radical frequently used as an antioxidant. Melatonin played a role in increasing immune response, and supporting cytoprotective process.
Riani, Rizqi Indah   +1 more
core  

Randomized trial of polychromatic blue-enriched light for circadian phase shifting, melatonin suppression, and alerting responses. [PDF]

open access: yes, 2019
Wavelength comparisons have indicated that circadian phase-shifting and enhancement of subjective and EEG-correlates of alertness have a higher sensitivity to short wavelength visible light.
Ayers, M.   +12 more
core   +2 more sources

Basizität im angeregten Zustand verändert die Selektivität der aromatischen Deuterierung: Anwendung auf die Late‐Stage Markierung von Pharmazeutika

open access: yesAngewandte Chemie, EarlyView.
Wir präsentieren eine metallfreie Methode für die Deuteriummarkierung von Aromaten in deuteriertem HFIP. Dieser Ansatz nutzt die erhöhte Basizität von Aromaten im angeregten Zustand, um den selektiven Wasserstoffisotopenaustausch an schwer zugänglichen Positionen zu ermöglichen.
Eva Rivera‐Chao   +5 more
wiley   +1 more source

Effects of photodynamic therapy using bisdemethoxycurcumin combined with melatonin or acetyl-melatonin on C. Albicans

open access: yesScientific Reports
The current study aims to explore the efficacy of antifungal photodynamic therapy (PDT) on C. albicans biofilms by combining photosensitizers, bisdemethoxycurcumin (BDMC), and melatonin (MLT) or acetyl-melatonin (AcO-MLT).
Maria Margarita D. Duterte   +4 more
doaj   +1 more source

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