Results 101 to 110 of about 227,315 (399)

Melatonin prevents Drp1‐mediated mitochondrial fission in diabetic hearts through SIRT1‐PGC1α pathway

Journal of Pineal Research, 2018
Myocardial contractile dysfunction is associated with an increase in mitochondrial fission in patients with diabetes. However, whether mitochondrial fission directly promotes diabetes‐induced cardiac dysfunction is still unknown.
Mingge Ding, Na Feng, Daishi Tang, Jiahao Feng, Zeyang Li, Ming Jia, Zhen-hua Liu, X. Gu, Yue-min Wang, F. Fu, J. Pei   +10 more
semanticscholar   +1 more source

Excited‐State Basicity Diverts the Site‐Selectivity of Aromatic Deuteration: Application to the Late‐Stage Labeling of Pharmaceuticals

Angewandte Chemie International Edition, EarlyView.
We present a metal‐free method for aromatic deuterium labeling via photoexcitation in deuterated HFIP. This approach leverages the enhanced basicity of excited‐state aromatics to achieve selective hydrogen isotope exchange at challenging positions. Demonstrated on complex drug molecules, this efficient strategy provides a valuable tool for isotope ...
Eva Rivera‐Chao, Javier Corpas, Giovanni Lonardi, Volker Derdau, Alessandro Ruffoni, Daniele Leonori   +5 more
wiley   +1 more source

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis [PDF]

, 2013
Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin,
Galley, H. F., Lowes, D. A., Murphy, M. P., Webster, N. R.   +3 more
core   +1 more source

Role of melatonin in sleep deprivation‐induced intestinal barrier dysfunction in mice

Journal of Pineal Research, 2019
Intestinal diseases caused by sleep deprivation (SD) are severe public health threats worldwide. This study focuses on the effect of melatonin on intestinal mucosal injury and microbiota dysbiosis in sleep‐deprived mice.
Ting Gao, Zixu Wang, Yulan Dong, Jing Cao, R. Lin, Xintong Wang, Zhengquan Yu, Yaoxing Chen   +7 more
semanticscholar   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Accepted Article.
Supported by rapid technological advancements, biocatalytic applications have matured into a sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon‐carbon frameworks and multiple ...
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe Bornscheuer   +4 more
wiley   +1 more source

A brief review about melatonin, a pineal hormone

Archives of Endocrinology and Metabolism, 2018
Melatonin is a ubiquitous molecule in nature, being locally synthesized in several cells and tissues, besides being a hormone that is centrally produced in the pineal gland of vertebrates, particularly in mammals.
F. G. do Amaral, J. Cipolla-Neto
semanticscholar   +1 more source

Mitophagy: A novel perspective for insighting into cancer and cancer treatment

Cell Proliferation, Volume 55, Issue 12, December 2022., 2022
Mitophagy is a physiological process regulated by complex and diverse mechanisms. Here we summarize the 15 main molecular mechanisms involved in the mammalian mitophagy processes and some potential anticancer drugs targeting mitophagy. Abstract Background Mitophagy refers to the selective self‐elimination of mitochondria under damaged or certain ...
Congkuan Song, Shize Pan, Jinjin Zhang, Ning Li, Qing Geng   +4 more
wiley   +1 more source

Lighting as a Circadian Rhythm-Entraining and Alertness-Enhancing Stimulus in the Submarine Environment [PDF]

, 2006
The human brain can only accommodate a circadian rhythm that closely follows 24 hours. Thus, for a work schedule to meet the brain’s hard-wired requirement, it must employ a 24 hour-based program.
Bullough, J. D., Crepeau, L. J., Figueiro, M. G., Porter, S., Rea, M. S.   +4 more
core   +1 more source

Is Melatonin the Cornucopia of the 21st Century?

Antioxidants, 2020
Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) and regulating the sleep/wake cycle in humans.
N. Ferlazzo, Giulia Andolina, Attilio Cannata, M. G. Costanzo, Valentina Rizzo, M. Currò, R. Ientile, D. Caccamo   +7 more
semanticscholar   +1 more source

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, EarlyView.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source