Results 1 to 10 of about 335 (142)

Meldonium determination in milk and meat through UHPLC-HRMS [PDF]

Heliyon, 2020
A simple and sensitive procedure for the quantification of meldonium in milk and meat by UHPLC-HRMS is presented. Some products were investigated to contain this substance due to using a veterinary drug called “Emidonol”. According to the instruction for
A. Temerdashev, A. Azaryan, E. Dmitrieva
doaj   +5 more sources

Insights into the pharmacodynamics and pharmacokinetics of meldonium after exposure to acute high altitude [PDF]

Frontiers in Pharmacology, 2023
Objective: Meldonium, a well-known cardioprotective drug, has been reported to be protective against pulmonary injury at high altitudes; however, the pharmacodynamics of meldonium in other vital organs under acute high-altitude injury are less ...
Fengying Liu, Xin Sui, Qian Wang, Jinglai Li, Weijie Yang, Yi Yang, Zhenyu Xiao, Yangyang Sun, Xiaoxuan Guo, Xiaoxuan Guo, Xinyi Yang, Jun Yang, Yongan Wang, Yuan Luo   +13 more
doaj   +2 more sources

Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis [PDF]

Frontiers in Pharmacology, 2022
Hypoxic environments at high altitudes influence the long-term non-altitude health of residents, by inducing changes in metabolism and the mitochondria, severe lung injury, and endangering life.
Daohui Wang, Daohui Wang, Fengying Liu, Weijie Yang, Yangyang Sun, Xiaoning Wang, Xin Sui, Jun Yang, Qian Wang, Wenhao Song, Minmin Zhang, Zhenyu Xiao, Tian Wang, Yongan Wang, Yuan Luo   +14 more
doaj   +2 more sources

CYTOPROTECTIVE EFFECT OF MELDONIUM ON CARDIOMYOCYTE

Arta Medica, 2023
Background. The use of myocardial cytoprotectors (meldonium) in patients with exertional angina is a scientific-practical dilemma. Material and methods. An open randomized clinical trial was conducted involving 160 patients with chronic heart failure (
Olga Chetruș
doaj   +4 more sources

Case report of three patients with end-stage recurrent glioblastoma treated with meldonium [PDF]

BJC Reports
Background Glioblastoma is the most aggressive primary brain tumor in adults. The prognosis is still very poor with a median survival time less than a year.
Sandra Bien-Möller, Martin E. Weidemeier, Josefine Radke, Jörg Baldauf, Stefan Engeli, Mladen V. Tzvetkov, Henry W. S. Schroeder   +6 more
doaj   +2 more sources

Region-specific neuroprotective effects of meldonium pretreatment in two models of sepsis-associated encephalopathy [PDF]

Frontiers in Pharmacology
Sepsis-associated encephalopathy (SAE) is a common yet poorly understood complication of sepsis, which poses a burden in clinical settings, as its management relies on supportive care without targeted pharmacological interventions.
Aleksandra Ružičić, Tijana Srdić, Katarina Bobić, Dunja Drakulić, Filip Veljković, Ana Todorović, Siniša Đurašević, Iva Lakić   +7 more
doaj   +2 more sources

Meldonium-induced steatosis is associated with increased delta 6 desaturation and reduced elongation of n-6 polyunsaturated fatty acids [PDF]

Liver Research
Background and objective: Metabolic associated fatty liver disease (MAFLD) is associated with abnormal lipid metabolism. Mitochondrial dysfunction is considered an important factor in the onset of MAFLD, whereas altered fatty acid composition has been ...
Bodil Bjørndal, Siri Lunde Tungland, Pavol Bohov, Magne O. Sydnes, Simon N. Dankel, Lise Madsen, Rolf K Berge   +6 more
doaj   +2 more sources

Novel energy optimizer, meldonium, rapidly restores acute hypobaric hypoxia-induced brain injury by targeting phosphoglycerate kinase 1 [PDF]

Cell Communication and Signaling
Background Acute hypobaric hypoxia-induced brain injury has been a challenge in the health management of mountaineers; therefore, new neuroprotective agents are urgently required.
Fengying Liu, Huanhuan He, Weijie Yang, Daohui Wang, Xin Sui, Yangyang Sun, Shuai Wang, Yi Yang, Zhenyu Xiao, Jun Yang, Yongan Wang, Yuan Luo   +11 more
doaj   +2 more sources

The effects of meldonium on the acute ischemia/reperfusion liver injury in rats [PDF]

Scientific Reports, 2021
Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects
Siniša Đurašević, Maja Stojković, Jelena Sopta, Slađan Pavlović, Slavica Borković-Mitić, Anđelija Ivanović, Nebojša Jasnić, Tomislav Tosti, Saša Đurović, Jelena Đorđević, Zoran Todorović   +10 more
doaj   +2 more sources

Meldonium, as a potential neuroprotective agent, promotes neuronal survival by protecting mitochondria in cerebral ischemia–reperfusion injury [PDF]

Journal of Translational Medicine
Background Stroke is a globally dangerous disease capable of causing irreversible neuronal damage with limited therapeutic options. Meldonium, an inhibitor of carnitine-dependent metabolism, is considered an anti-ischemic drug.
Weijie Yang, Xiuxing Lei, Fengying Liu, Xin Sui, Yi Yang, Zhenyu Xiao, Ziqi cui, Yangyang Sun, Jun Yang, Xinyi Yang, Xueyang Lin, Zhenghao Bao, Weidong Li, Yingkai Ma, Yongan Wang, Yuan Luo   +15 more
doaj   +2 more sources