Results 31 to 40 of about 574 (170)
Рациональная фармакотерапия в кардиологии, 2015 Aim. To study meldonium effect in the combination therapy for ventricular repolarization disorders and cardiac electrical instability in patients with ischemic stroke.Material and methods. Patients (n=46) with acute phase of ischemic stroke were included
A. A. Abdullaev +3 more
doaj +5 more sources
METABOLIC CARDIOPROTECTION: NEW CONCEPTS IN IMPLEMENTATION OF CARDIOPROTECTIVE EFFECTS OF MELDONIUM [PDF]
Research Results in Pharmacology, 2016 Recent studies confirm the need to find means to correct ischemic / reperfusion injury due to the hemodynamic medicine, which are already known do not have the proper cardioprotective effects.
Lyudmila Danilenko +3 more
doaj +5 more sources
Acta Biomedica ScientificaBackground. The ambiguous effectiveness of cardiocytoprotectors and the low level of evidence for their use in coronary heart disease (CHD) necessitate the study of their direct effect on cell viability for assessing cytoprotective activity.The aim.
A. L. Khokhlov +4 more
doaj +2 more sources
Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism. [PDF]
Adv Sci (Weinh)Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Edwards RS +8 more
europepmc +2 more sources
Mildronate (meldonium): First, do no harm
, 2020 Meldonium (Mildronate) is used as a cardioprotective drug; however, it has not been officially approved anywhere outside the former Soviet Union (SU). The supposed action mechanism is based on the carnitine (Lcarnitine) lowering effect in muscular and cardiac tissues.
Jargin S.V.
openaire +2 more sources
Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19. [PDF]
Int J Mol Sci, 2021 Funding Information: Funding: This study was supported by the Latvian State Research Program project VPP‐COVID‐ 2020/1‐0014 ʺTowards new therapeutic and prophylactic treatments against Covid‐19 and corona‐ virusesʺ.
Vilskersts R +9 more
europepmc +2 more sources
The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats. [PDF]
Int J Mol Sci, 2021 Sepsis is a life-threatening condition caused by the dysregulated and overwhelming response to infection, accompanied by an exaggerated pro-inflammatory state and lipid metabolism disturbance leading to sequential organ failure.
Đurašević S +12 more
europepmc +3 more sources
Медицинский совет, 2022 Introduction. The number of patients with chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) is increasing every year. In both CHF and COPD, secondary mitochondrial dysfunction is observed.
M. E. Statsenko +3 more
doaj +1 more source
Разработка и регистрация лекарственных средств, 2019 A procedure for simultaneous quantitative determination of meldonium, L-carnitine, and γ-butyrobetaine in blood plasma by high-performance liquid chromatography with mass-selective detection and the isotopically labeled d9L-carnitine as internal standard
P. N. Sorokoumov +4 more
doaj +2 more sources
Angewandte Chemie, Volume 134, Issue 30, July 25, 2022., 2022 DfmD is a highly divergent member of the 2‐oxoglutarate‐dependent dioxygenase superfamily that catalyzes desaturation, rearrangement and demethylation of its substrate. In vitro biochemical studies and homology modeling suggest that these transformations occur via novel chemistry.
Elizabeth I. Parkinson +5 more
wiley +2 more sources