Results 31 to 40 of about 1,036 (190)

An Unusual Oxidative Rearrangement Catalyzed by a Divergent Member of the 2‐Oxoglutarate‐Dependent Dioxygenase Superfamily during Biosynthesis of Dehydrofosmidomycin

Angewandte Chemie, Volume 134, Issue 30, July 25, 2022., 2022
DfmD is a highly divergent member of the 2‐oxoglutarate‐dependent dioxygenase superfamily that catalyzes desaturation, rearrangement and demethylation of its substrate. In vitro biochemical studies and homology modeling suggest that these transformations occur via novel chemistry.
Elizabeth I. Parkinson, Hani G. Lakkis, Amir A. Alwali, Mary Elizabeth M. Metcalf, Ramya Modi, William W. Metcalf   +5 more
wiley   +2 more sources

Cardioprotective Activity of Pharmacological Agents Affecting NO Production and Bioavailability in the Early Postnatal Period after Intrauterine Hypoxia in Rats. [PDF]

Biomedicines, 2023
Intrauterine hypoxia in newborns leads to a multifaceted array of alterations that exert a detrimental impact on the cardiovascular system. The aim of this research was to assess the cardioprotective effects of modulators of the nitric oxide (NO) system,
Popazova O, Belenichev I, Bukhtiyarova N, Ryzhenko V, Oksenych V, Kamyshnyi A.   +5 more
europepmc   +3 more sources

COVID-19: the place of metabolic correctors in the therapy of patients with post-COVID syndrome

Лечащий Врач, 2022
The frequency of post-COVID syndrome in patients treated on an outpatient basis ranges from 10% to 35%, while in patients who have had a severe disease requiring hospitalization, the frequency of post-COVID syndrome can reach 80%.
G. A. Baryshnikova, S. A. Chorbinskaya, T. A. Zimina, I. I. Stepanova, N. A. Kudryavtseva   +4 more
doaj   +1 more source

Left ventricular noncompaction cardiomyopathy and short QT syndrome due to primary carnitine deficiency

Annals of Noninvasive Electrocardiology, Volume 28, Issue 6, November 2023., 2023
A 13‐year‐old patient with palpitations and syncope was diagnosed with a rare, reversible cause of short QT syndrome (SQTS) and cardiomyopathy—primary carnitine deficiency (PCD) caused by a mutation in the SLC22A5 gene. Treatment with carnitine supplementation corrected her QT interval to within normal range, with significant improvement in ventricular
Oliver P. Hanington, Catherine Armstrong, Germaine Pierre, Graham Stuart, Jules C. Hancox   +4 more
wiley   +1 more source

Dried blood spots for doping controls—Development of a comprehensive initial testing procedure with fully automated sample preparation

Biomedical Chromatography, Volume 37, Issue 8, August 2023., 2023
Abstract Currently, primarily urine, whole blood and serum samples are analyzed for doping‐relevant substances in professional sports, but recently dried blood spots (DBS) have been introduced as complementary matrix, offering advantageous features, e.g. a minimally invasive sampling procedure.
Ann‐Marie Garzinsky, Andreas Thomas, Sven Guddat, Christian Görgens, Josef Dib, Mario Thevis   +5 more
wiley   +1 more source

Analysis of doping control samples using supercritical fluid chromatography‐tandem mass spectrometry: Ready for routine use

Journal of Separation Science, Volume 46, Issue 7, April 2023., 2023
Supercritical fluid chromatography is proving to be a good separation and sample preparation tool for various analytical applications and, as such, has gained the attention of the anti‐doping community. Here, the applicability of supercritical fluid chromatography hyphenated to tandem mass spectrometry for routine doping control analysis was tested.
Bernhard Wuest, Ivana Gavrilović, David Cowan, Xavier de la Torre, Francesco Botrè, Maria Kristina Parr   +5 more
wiley   +1 more source

Annual banned‐substance review—Analytical approaches in human sports drug testing 2021/2022–

Drug Testing and Analysis, Volume 15, Issue 1, Page 5-26, January 2023., 2023
Detection assays for drugs and methods of sports doping published between 2021 and 2022 are critically reviewed and evaluated in context with the Prohibited List 2022 as established by the World Anti‐Doping Agency. Abstract Also in 2021/2022, considerable efforts were invested into advancing human sports drug testing programs, recognizing and taking ...
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

New opportunities in the treatment of asthenic symptoms after a new coronavirus infection

Медицинский совет, 2022
Introduction. Asthenia is an urgent problem during the pandemic of new coronavirus infection (COVID-19) because of its high frequency regardless of the severity of the disease.The purpose of this subanalysis of data from the multicenter controlled ...
V. N. Shishkova, A. I. Martynov
doaj   +1 more source

Annual banned‐substance review: Analytical approaches in human sports drug testing 2020/2021

Drug Testing and Analysis, Volume 14, Issue 1, Page 7-30, January 2022., 2022
Detection assays for drugs and methods of sports doping published between 2020 and 2021 are critically reviewed and evaluated in context with the Prohibited List 2021 as established by the World Anti‐Doping Agency. Abstract Most core areas of anti‐doping research exploit and rely on analytical chemistry, applied to studies aiming at further improving ...
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Meldonium residues in milk: A possible scenario for inadvertent doping in sports?

Drug Testing and Analysis, Volume 13, Issue 11-12, Page 1906-1910, November-December 2021., 2021
The veterinary drug Emidonol® has been discussed as a possible scenario for inadvertent doping in sports. In a recent study, meldonium concentrations determined in raw milk reached up to 701 ng/ml. If consumed, urine collected post‐ingestion can present meldonium residues and adverse analytical findings in doping controls cannot be excluded.
Sven Guddat, Christian Görgens, Tim Sobolevsky, Mario Thevis   +3 more
wiley   +1 more source