Meldonium and neuroprotection. Theory, experiment and clinical practice.
Medičnì Perspektivi, 2018 In this review the possibilities of correction of brain metabolism in cases of acute cerebral ischemia (ACI) under using meldonium were considered. The biochemical specificity of this remedy in Krebs cycle, influence on cerebral glycolysis, by activating
V. P. Muslin, O. V. Pohorielov
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Application of Meldonium for the Treatment of Patients with Diabetic Nephropathy [PDF]
Львівський клінічний вісник, 2013 Introduction. Today, the life expectancy of people with diabetes mellitus (DM) has increased by several times. Mortality due to the acute complications of diabetes, such as diabetic coma, does not exceed 1.0%.
І. І. Топчій
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MELDONIUM EFFICACY IN CHRONIC CEREBROVASCULAR DISEASES
Медицинский совет, 2016 The evidential base of meldonium in chronic cerebral ischemia is critically reviewed in the article.
M. A. DOMASHENKO, M. Yu. MAKSIMOVA
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EFFICACY OF MELDONIUM IN ACUTE PERIOD OF ISCHEMIC STROKE
Alʹmanah Kliničeskoj Mediciny, 2016 Background: As long as systemic thrombolysis is indicated to not more than 10% of patients with ischemic stroke, the search for medical agents for basic treatment of stroke is an important problem of today’s neurology.Aim: To evaluate efficacy of ...
S. V. Kotov +4 more
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Effects of meldonium on the behavior of rats in a model of lipopolysaccharide-induced systemic inflammation [PDF]
PharmaciaMeldonium is a metabolic modulator used for its cardioprotective properties and presumed ergogenic effects. The current study aimed to determine its psychopharmacological effects in rats subjected to a model of neuroinflammation.
Klementina Moneva-Marinova +6 more
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Meldonium – a new challenging subject in the performance sport [PDF]
One Health & Risk Management, 2023 Introduction. Nowadays sports have become a business that breaks any rules of Olympic ethics in order to win. The Doping phenomenon with artificial increase of athlete’s performance opposes the principle of fair and equitable competition. Abusive use of
Tatiana TIMERCAN
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Meldonium and human sport performance: a narrative review evaluating the evidence for ergogenic potential [PDF]
Frontiers in Sports and Active LivingMeldonium has attracted considerable attention in sports due to its suggested effects on energy metabolism and high-profile doping cases. This narrative review evaluates Meldonium's biochemical mechanisms, pharmacokinetics, safety profile, and the ...
Christer Malm +3 more
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The Effects of Meldonium on the Renal Acute Ischemia/Reperfusion Injury in Rats [PDF]
International Journal of Molecular Sciences, 2019 Acute renal ischemia/reperfusion (I/R) injury is a clinical condition that is challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, in this study we investigated the effects of a four-week meldonium pre-treatment (300 mg/kg b.m./day) on acute renal I ...
Siniša Đurašević +11 more
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Hyperpolarized magnetic resonance shows that the anti‐ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post‐ischemic function in the diabetic heart [PDF]
NMR in Biomedicine, 2021 The diabetic heart has a decreased ability to metabolize glucose. The anti‐ischemic drug meldonium may provide a route to counteract this by reducing l‐carnitine levels, resulting in improved cardiac glucose utilization.
Dragana Savic +2 more
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Meldonium, as a potential neuroprotective agent, promotes neuronal survival by protecting mitochondria in cerebral ischemia–reperfusion injury [PDF]
Journal of Translational MedicineBackground Stroke is a globally dangerous disease capable of causing irreversible neuronal damage with limited therapeutic options. Meldonium, an inhibitor of carnitine-dependent metabolism, is considered an anti-ischemic drug.
Weijie Yang +15 more
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