Results 11 to 20 of about 587 (136)

Case report of three patients with end-stage recurrent glioblastoma treated with meldonium [PDF]

BJC Reports
Background Glioblastoma is the most aggressive primary brain tumor in adults. The prognosis is still very poor with a median survival time less than a year.
Sandra Bien-Möller, Martin E. Weidemeier, Josefine Radke, Jörg Baldauf, Stefan Engeli, Mladen V. Tzvetkov, Henry W. S. Schroeder   +6 more
doaj   +3 more sources

Region-specific neuroprotective effects of meldonium pretreatment in two models of sepsis-associated encephalopathy [PDF]

Frontiers in Pharmacology
Sepsis-associated encephalopathy (SAE) is a common yet poorly understood complication of sepsis, which poses a burden in clinical settings, as its management relies on supportive care without targeted pharmacological interventions.
Aleksandra Ružičić, Tijana Srdić, Katarina Bobić, Dunja Drakulić, Filip Veljković, Ana Todorović, Siniša Đurašević, Iva Lakić   +7 more
doaj   +3 more sources

Novel energy optimizer, meldonium, rapidly restores acute hypobaric hypoxia-induced brain injury by targeting phosphoglycerate kinase 1 [PDF]

Cell Communication and Signaling
Background Acute hypobaric hypoxia-induced brain injury has been a challenge in the health management of mountaineers; therefore, new neuroprotective agents are urgently required.
Fengying Liu, Huanhuan He, Weijie Yang, Daohui Wang, Xin Sui, Yangyang Sun, Shuai Wang, Yi Yang, Zhenyu Xiao, Jun Yang, Yongan Wang, Yuan Luo   +11 more
doaj   +3 more sources

Meldonium-induced steatosis is associated with increased delta 6 desaturation and reduced elongation of n-6 polyunsaturated fatty acids [PDF]

Liver Research
Background and objective: Metabolic associated fatty liver disease (MAFLD) is associated with abnormal lipid metabolism. Mitochondrial dysfunction is considered an important factor in the onset of MAFLD, whereas altered fatty acid composition has been ...
Bodil Bjørndal, Siri Lunde Tungland, Pavol Bohov, Magne O. Sydnes, Simon N. Dankel, Lise Madsen, Rolf K Berge   +6 more
doaj   +4 more sources

CYTOPROTECTIVE EFFECT OF MELDONIUM ON CARDIOMYOCYTE [PDF]

Arta Medica, 2023
Background. The use of myocardial cytoprotectors (meldonium) in patients with exertional angina is a scientific-practical dilemma. Material and methods. An open randomized clinical trial was conducted involving 160 patients with chronic heart failure (
Olga Chetruș
doaj   +2 more sources

Meldonium and neuroprotection. Theory, experiment and clinical practice. [PDF]

Medičnì Perspektivi, 2018
In this review the possibilities of correction of brain metabolism in cases of acute cerebral ischemia (ACI) under using meldonium were considered. The biochemical specificity of this remedy in Krebs cycle, influence on cerebral glycolysis, by activating
V. P. Muslin, O. V. Pohorielov
doaj   +3 more sources

Meldonium – a new challenging subject in the performance sport [PDF]

One Health & Risk Management, 2023
Introduction. Nowadays sports have become a business that breaks any rules of Olympic ethics in order to win. The Doping phenomenon with artificial increase of athlete’s performance opposes the principle of fair and equitable competition. Abusive use of
Tatiana TIMERCAN
doaj   +2 more sources

Effects of meldonium on the behavior of rats in a model of lipopolysaccharide-induced systemic inflammation [PDF]

Pharmacia
Meldonium is a metabolic modulator used for its cardioprotective properties and presumed ergogenic effects. The current study aimed to determine its psychopharmacological effects in rats subjected to a model of neuroinflammation.
Klementina Moneva-Marinova, Silvia Gancheva, Nadezhda Hvarchanova, Marieta Georgieva, Stanila Stoeva-Grigorova, Maya Radeva-Ilieva, Kaloyan D. Georgiev   +6 more
doaj   +4 more sources

Meldonium Improves Functional Capacity in Patients with Right Ventricular Failure. [PDF]

J Clin Med
Background/Objectives: Right ventricular (RV) failure (RVF) is associated with poor prognosis and currently has no known treatment. Meldonium is a clinically used cardiometabolic drug that improves RV function in a preclinical RVF model. This study aimed
Kigitovica D, Dzirnieks K, Lejnieks A, Dambrova M, Skride A, Vilskersts R.   +5 more
europepmc   +2 more sources

Integrated Photoelectrode and Electrolyte Engineering via Carbon Quantum Dots for Self‐Powered H2O/O2‐Mediated Portable Photoelectrochemical Cells [PDF]

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Surface‐charged N‐CQDs serve as both electrolyte additives and photocathode modifiers. Electrodeposited N‐CQDs on Cu2O form a stable composite, steering 4e− ORR toward water. A quasi‐solid electrolyte with N‐CQDs aids charge migration, electrode‐electrolyte interfacial compatibility and replenishes active sites.
Yang Wu, Hui‐Min Duan, Chen‐Guang Li, Tian‐Xu Zeng, Jian‐Long Li, Xue‐Tong Cheng, Yun Jing, Wei‐Zhe Li, Qing Li, Xu Tian, Jiwu Zhao, Anders Thapper, Hong‐Yan Wang   +12 more
wiley   +2 more sources