Results 11 to 20 of about 1,036 (190)
METABOLIC CARDIOPROTECTION: NEW CONCEPTS IN IMPLEMENTATION OF CARDIOPROTECTIVE EFFECTS OF MELDONIUM [PDF]
Research Results in Pharmacology, 2016 Recent studies confirm the need to find means to correct ischemic / reperfusion injury due to the hemodynamic medicine, which are already known do not have the proper cardioprotective effects.
Lyudmila Danilenko +3 more
doaj +13 more sources
Meldonium – A High Potential Drug. Literature Review [PDF]
Quality in SportIntroduction and purpose: Meldonium is a long-established substance. Initially, the substance was only available in the former Soviet Union; now the drug can be obtained, for example, in Poland.
Michał Ochwat +7 more
doaj +4 more sources
Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism. [PDF]
Adv Sci (Weinh)Carnitine and its acyl derivatives are essential for the transport of fatty acids from the cytosol into the mitochondrial matrix for β-oxidation, which supplies the cell with energy.
Edwards RS +8 more
europepmc +4 more sources
Meldonium, as a potential neuroprotective agent, promotes neuronal survival by protecting mitochondria in cerebral ischemia–reperfusion injury [PDF]
Journal of Translational MedicineBackground Stroke is a globally dangerous disease capable of causing irreversible neuronal damage with limited therapeutic options. Meldonium, an inhibitor of carnitine-dependent metabolism, is considered an anti-ischemic drug.
Weijie Yang +15 more
doaj +2 more sources
New data on well-known drug: focus on meldonium
Медицинский совет, 2021 The article reviews the efficacy of meldonium in patients with various diseases, which are based on secondary mitochondrial dysfunction. Mitochondria are complex cellular organelles that control many metabolic processes, including fatty acid oxidation ...
M. E. Statsenko +2 more
doaj +3 more sources
Meldonium and neuroprotection. Theory, experiment and clinical practice.
Medičnì Perspektivi, 2018 In this review the possibilities of correction of brain metabolism in cases of acute cerebral ischemia (ACI) under using meldonium were considered. The biochemical specificity of this remedy in Krebs cycle, influence on cerebral glycolysis, by activating
V. P. Muslin, O. V. Pohorielov
doaj +3 more sources
Meldonium use by athletes at the Baku 2015 European Games [PDF]
British Journal of Sports Medicine, 2016 BackgroundThe aim of this report was to estimate the prevalence of meldonium use in athletes competing in the Baku 2015 European Games to contribute to the surveillance of substances on the 2015 World Anti-Doping Agency (WADA) Monitoring Program. Meldonium is reported to be used by athletes to potentially enhance personal performance and shorten the ...
Mark, Stuart +2 more
exaly +3 more sources
MELDONIUM EFFICACY IN CHRONIC CEREBROVASCULAR DISEASES
Медицинский совет, 2016 The evidential base of meldonium in chronic cerebral ischemia is critically reviewed in the article.
M. A. DOMASHENKO, M. Yu. MAKSIMOVA
doaj +3 more sources
Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses [PDF]
Drug Testing and Analysis, 2017 Although developed as a therapeutic medication, meldonium has found widespread use in human sports and was recently added to the World Anti‐Doping Agency's list of prohibited substances. Its reported abuse potential in human sports has led to concern by regulatory authorities about the possible misuse of meldonium in equine athletics.
Heather K Knych, Mikael Hedeland
exaly +3 more sources
MELDONIUM: EFFECTIVE ACTION POINTS
Кардиоваскулярная терапия и профилактика, 2013 The paper is focused on hypoxia and cell ischemia as universal pathogenetic mechanisms of disease development, which can be addressed by both etiotropic and pathogenetic therapy. The latter is represented by the so-called metabolic correctors. At present,
A. L. Vertkin +4 more
doaj +3 more sources