Results 1 to 10 of about 587 (136)
Insights into the pharmacodynamics and pharmacokinetics of meldonium after exposure to acute high altitude [PDF]
Frontiers in Pharmacology, 2023 Objective: Meldonium, a well-known cardioprotective drug, has been reported to be protective against pulmonary injury at high altitudes; however, the pharmacodynamics of meldonium in other vital organs under acute high-altitude injury are less ...
exaly +4 more sources
Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis [PDF]
Frontiers in Pharmacology, 2022 Hypoxic environments at high altitudes influence the long-term non-altitude health of residents, by inducing changes in metabolism and the mitochondria, severe lung injury, and endangering life.
Tian Wang
exaly +4 more sources
The effects of meldonium on the acute ischemia/reperfusion liver injury in rats [PDF]
Scientific Reports, 2021 Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects
Siniša Đurašević +10 more
doaj +3 more sources
Meldonium determination in milk and meat through UHPLC-HRMS
Heliyon, 2020 A simple and sensitive procedure for the quantification of meldonium in milk and meat by UHPLC-HRMS is presented. Some products were investigated to contain this substance due to using a veterinary drug called “Emidonol”. According to the instruction for
Ekaterina Dmitrieva +1 more
exaly +3 more sources
Медицинский совет, 2022 Introduction. The number of patients with chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) is increasing every year. In both CHF and COPD, secondary mitochondrial dysfunction is observed.
M. E. Statsenko +3 more
doaj +1 more source
Angewandte Chemie, Volume 134, Issue 30, July 25, 2022., 2022 DfmD is a highly divergent member of the 2‐oxoglutarate‐dependent dioxygenase superfamily that catalyzes desaturation, rearrangement and demethylation of its substrate. In vitro biochemical studies and homology modeling suggest that these transformations occur via novel chemistry.
Elizabeth I. Parkinson +5 more
wiley +2 more sources
New data on well-known drug: focus on meldonium
Медицинский совет, 2021 The article reviews the efficacy of meldonium in patients with various diseases, which are based on secondary mitochondrial dysfunction. Mitochondria are complex cellular organelles that control many metabolic processes, including fatty acid oxidation ...
M. E. Statsenko +2 more
doaj +1 more source
COVID-19: the place of metabolic correctors in the therapy of patients with post-COVID syndrome
Лечащий Врач, 2022 The frequency of post-COVID syndrome in patients treated on an outpatient basis ranges from 10% to 35%, while in patients who have had a severe disease requiring hospitalization, the frequency of post-COVID syndrome can reach 80%.
G. A. Baryshnikova +4 more
doaj +1 more source
Annals of Noninvasive Electrocardiology, Volume 28, Issue 6, November 2023., 2023 A 13‐year‐old patient with palpitations and syncope was diagnosed with a rare, reversible cause of short QT syndrome (SQTS) and cardiomyopathy—primary carnitine deficiency (PCD) caused by a mutation in the SLC22A5 gene. Treatment with carnitine supplementation corrected her QT interval to within normal range, with significant improvement in ventricular
Oliver P. Hanington +4 more
wiley +1 more source
Biomedical Chromatography, Volume 37, Issue 8, August 2023., 2023 Abstract Currently, primarily urine, whole blood and serum samples are analyzed for doping‐relevant substances in professional sports, but recently dried blood spots (DBS) have been introduced as complementary matrix, offering advantageous features, e.g. a minimally invasive sampling procedure.
Ann‐Marie Garzinsky +5 more
wiley +1 more source