Results 41 to 50 of about 587 (136)

USE OF MELDONIUM IN THE TREATMENT OF PATIENTS WITH CORONARY ARTERY DISEASE AND CONCOMITANT ARTERIAL HYPERTENSION [PDF]

, 2019
Coronary artery disease (CAD) remains one of the leading causes of mortality and disability in Ukraine. Arterial hypertension (AH) is one of the most common diseases and a leading risk factor for coronary artery disease.
Vakaliuk, Ihor, Denys Volynskyi, Volynskyi, Denys, Ihor Vakaliuk   +3 more
core   +3 more sources

Fluorescence chemosensing of meldonium using a cross-reactive sensor array

, 2020
In this paper, we report a fluorescent sensor array approach for the urinary detection of a prohibited substance in sports, meldonium. Four chemosensors with ethidium bromide scaffolds were employed in this method.
Erkmen, Cem, Taskin-Tok, Tugba, Yalcin, Ergin, Tok, Tuğba Taşkın, Caglayan, Mehmet Gokhan, Yalçın, Ergin   +5 more
core   +1 more source

Carnitine and γ‐Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2‐mediated Transport [PDF]

, 2017
Publisher Copyright: © 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)Meldonium (3-(2,2,2-trimethylhydrazinium)propionate) is the most potent clinically used inhibitor of organic cation transporter 2 (OCTN2 ...
Helena Cirule, Dace Hartmane, Edgars Liepinsh, Liepinsh, Edgars, Eduards Sevostjanovs, Olga Zharkova‐Malkova, Elina Makarova, Grinberga, Solveiga, Sevostjanovs, Eduards, Solveiga Grinberga, Makarova, Elina, Maija Dambrova, Hartmane, Dace, Zharkova-Malkova, Olga, Cirule, Helena, Dambrova, Maija   +15 more
core   +1 more source

The effects of meldonium on the renal acute ischemia/reperfusion injury in rats [PDF]

, 2019
Acute renal ischemia/reperfusion (I/R) injury is a clinical condition that is challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis.
Borković-Mitić, Slavica S., Bogdanović, Ljiljana, Grigorov, Ilijana, Đorđević, Jelena, Popović-Đorđević, Jelena, Borković-Mitić, Slavica, Stojković, Maja, Jasnić, Nebojša, Todorović, Zoran, Pavlović, Slađan, Đurović, Saša, Borković Mitić, Slavica, Bogojević, Desanka, Todorović, Zoran B., Tosti, Tomislav, Đurašević, Siniša, Pavlović, Slađan Z., Pavlović, Sladan   +17 more
core   +2 more sources

Meldonium: drug which brought disrepute to sport [PDF]

, 2017
World of sports have been rocked by doping scandals every now and then and World Anti-Doping Agency(WADA) has banned several offending drugs at different times to counter this menace.
Smita Das, Mohanty, Rashmi Ranjan, Das, Smita, Rashmi Ranjan Mohanty, Meher, Bikash Ranjan, Bikash Ranjan Meher   +5 more
core   +1 more source

The Possibilities of Working Capacity Maintenance at Organophosphorous Compounds Intoxication

Вестник войск РХБ защиты, 2023
The experience of modern local armed conflicts and the monitoring of terrorist activity in the world indicate the possibility of the affection of people by organophosphorus compounds (OPs) in combat and as a result of industrial accidents and terrorist ...
A. Yu. Mikshta, L. P. Erdniev, A. A. Vlasov, I. V. Legotin, I. A. Ermolaeva, S. A. Komissarenko, I. A. Nelga   +6 more
doaj   +1 more source

Metformin Lowers Plasma Triacylglycerol Levels in Mice with Impaired Carnitine Biosynthesis and Fatty Liver

SynBio
The antidiabetic drug metformin has a wide range of metabolic effects and may also reduce the risk of obesity-related diseases. The aim of the current study was to investigate if metformin could counteract meldonium-induced fatty liver.
Bodil Bjørndal, Tra-My Thi Le, Elin Strand, Lise Madsen, Rolf K. Berge   +4 more
doaj   +1 more source

The Effects of a Meldonium Pre-Treatment on the Sepsis-Induced Rat Heart Injury

, 2021
Background: Sepsis is a life-threatening condition caused by the dysregulated and overwhelming response to infection, accompanied by exaggerated pro-inflammatory state and lipid metabolism disturbance leading to sequential organ failure.1, 2 Meldonium is
Lakić, Iva, Stanković, Sanja, Grigorov, Ilijana, Đorđević, Jelena, Glumac, Sofija, Jasnić, Nebojša, Todorović, Zoran, Pavlović, Slađan, Đurović, Saša, Borković Mitić, Slavica, Tosti, Tomislav, Đurašević, Siniša, Ružičić, Aleksandra   +12 more
core   +5 more sources

Misuse of the metabolic modulator meldonium in sports [PDF]

, 2016
Meldonium is currently claimed to be a relatively safe agent in patients needing anti-ischaemic therapy, but there is no compelling evidence that it may be effective in improving athletic performance, nor that its administration may be safe in healthy ...
Giuseppe Lippi, Camilla Mattiuzzi, Mattiuzzi, Camilla, Lippi, Giuseppe   +3 more
core   +1 more source

Concepts for a New Rapid and Simple HPLC Method for Simultaneous Determination of Metoprolol and Meldonium in Pharmaceutical Dosage Forms

Scientia Pharmaceutica, 2022
Simultaneous determination of the tandem of drugs, like meldonium and metoprolol, with enormous polarity differences between them, requires thorough research and careful selection of chromatographic conditions.
Marjan Piponski, Mariana Horyn, Kristina Grncaroska, Oleksandra Oleshchuk, Elena Petrovska, Stefan Angelevski, Tetyana Uglyar, Tetyana Kucher, Liliya Logoyda   +8 more
doaj   +1 more source