Meldonium Supplementation in Professional Athletes: Career Destroyer or Lifesaver? [PDF]
CureusMeldonium is a substance with known anti-anginal effects demonstrated by numerous studies and human clinical trials; however, it does not possess marketing authorization within the European Union, only in ex-Soviet republics. Since 2016, meldonium has been included by the World Anti-doping Agency (WADA) on the S4 list of metabolic modulators.
Pușcaș A +8 more
europepmc +3 more sources
Meldonium: drug which brought disrepute to sport [PDF]
International Journal of Basic & Clinical Pharmacology, 2017 World of sports have been rocked by doping scandals every now and then and World Anti-Doping Agency(WADA) has banned several offending drugs at different times to counter this menace. Meldonium is the recent addition to the long list of drugs banned by WADA to prevent its misuse among the athletes.
Bikash Ranjan Meher +2 more
openaire +3 more sources
Pharmacological Research, 2016 Meldonium (mildronate; 3-(2,2,2-trimethylhydrazinium)propionate; THP; MET-88) is a clinically used cardioprotective drug, which mechanism of action is based on the regulation of energy metabolism pathways through l-carnitine lowering effect. l-Carnitine biosynthesis enzyme γ-butyrobetaine hydroxylase and carnitine/organic cation transporter type 2 ...
Maija Dambrova +2 more
exaly +3 more sources
EFFICACY OF MELDONIUM IN ACUTE PERIOD OF ISCHEMIC STROKE
Alʹmanah Kliničeskoj Mediciny, 2016 Background: As long as systemic thrombolysis is indicated to not more than 10% of patients with ischemic stroke, the search for medical agents for basic treatment of stroke is an important problem of today’s neurology.Aim: To evaluate efficacy of ...
S. V. Kotov +4 more
doaj +3 more sources
Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19. [PDF]
Int J Mol Sci, 2021 Funding Information: This study was supported by the Latvian State Research Program project VPP?COVID? 2020/1?0014 ?Towards new therapeutic and prophylactic treatments against Covid?19 and corona-viruses?.
Vilskersts R +9 more
europepmc +4 more sources
Hyperpolarized magnetic resonance shows that the anti‐ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post‐ischemic function in the diabetic heart [PDF]
NMR in Biomedicine, 2021 Dragana Savic, Vicky Ball, David Hauton
exaly +2 more sources
Use of Meldonium in the Treatment of Patients with Coronary Artery Disease and Concomitant Arterial Hypertension [PDF]
, 2019 Coronary artery disease (CAD) remains one of the leading causes of mortality and disability in Ukraine. Arterial hypertension (AH) is one of the most common diseases and a leading risk factor for coronary artery disease.The aim of the work is to evaluate
Vakaliuk, I. (Ihor) +1 more
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Lipidomics Provides New Insight into Pathogenesis and Therapeutic Targets of the Ischemia-Reperfusion Injury. [PDF]
Int J Mol Sci, 2021 Lipids play an essential role in both tissue protection and damage. Tissue ischemia creates anaerobic conditions in which enzyme inactivation occurs, and reperfusion can initiate oxidative stress that leads to harmful changes in membrane lipids, the ...
Todorović Z +9 more
europepmc +4 more sources
Медицинский совет, 2022 Introduction. The number of patients with chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) is increasing every year. In both CHF and COPD, secondary mitochondrial dysfunction is observed.
M. E. Statsenko +3 more
doaj +1 more source
β-Hydroxy β-Methyl Butyric Acid (HMB) and Its Potential Doping Relevance: A Pilot Study on Its Urinary Excretion Profile. [PDF]
Drug Test Analβ‐hydroxy β‐methyl butyric acid (HMB), either as the free acid or in the form of its calcium salt, is a component of several dietary supplements marketed to enhance sports performance. We investigated the urinary excretion profile of HMB, also assessing the endogenous reference ranges of HMB in human urine samples from healthy volunteers (n = 20). Data
Camuto C +3 more
europepmc +2 more sources