Results 21 to 30 of about 574 (170)

Misuse of the metabolic modulator meldonium in sports

Journal of Sport and Health Science, 2017
Meldonium is currently claimed to be a relatively safe agent in patients needing anti-ischaemic therapy, but there is no compelling evidence that it may be effective in improving athletic performance, nor that its administration may be safe in healthy subjects.
LIPPI, Giuseppe, MATTIUZZI, Camilla
openaire   +5 more sources

THE EFFICACY OF MELDONIUM IN PATIENTS WITH CHRONIC HEART FAILURE OF ISCHEMIC ETIOLOGY WITH COMORBIDITIES

Медицинский совет, 2017
Нeart failure is common both in cardiac and noncardiac disease. We conducted a study that showed high efficacy and safety of meldonium in patients with heart failure and comorbidity.
M. E. Statsenko, S. V. Turkina, S. V. Fabritskaya, I. A. Tyschenko, L. V. Poletayeva   +4 more
doaj   +3 more sources

Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses [PDF]

Drug Testing and Analysis, 2017
Although developed as a therapeutic medication, meldonium has found widespread use in human sports and was recently added to the World Anti‐Doping Agency's list of prohibited substances. Its reported abuse potential in human sports has led to concern by regulatory authorities about the possible misuse of meldonium in equine athletics.
Heather K Knych, Scott D Stanley, Ulf Bondesson   +2 more
exaly   +3 more sources

Meldonium – A High Potential Drug. Literature Review

Quality in Sport
Introduction and purpose: Meldonium is a long-established substance. Initially, the substance was only available in the former Soviet Union; now the drug can be obtained, for example, in Poland. Originally, its action was observed in the cardiovascular system as an antianginal drug.
Michał Ochwat, Katarzyna Dąbek, Maria Sudoł, Martyna Piekarska, Anna Skowronek, Gabriela Mierzwa, Aleksandra Kajtel, Maria Ochwat   +7 more
openaire   +4 more sources

Meldonium Improves Functional Capacity in Patients with Right Ventricular Failure. [PDF]

J Clin Med
Background/Objectives: Right ventricular (RV) failure (RVF) is associated with poor prognosis and currently has no known treatment. Meldonium is a clinically used cardiometabolic drug that improves RV function in a preclinical RVF model. This study aimed to assess the safety and efficacy of meldonium in patients with pulmonary arterial hypertension ...
Kigitovica D, Dzirnieks K, Lejnieks A, Dambrova M, Skride A, Vilskersts R.   +5 more
europepmc   +3 more sources

ASTHENIC DISORDERS IN ELDERLY PATIENTS WITH ARTERIAL HYPERTENSION: MANAGEMENT POTENTIAL OF MELDONIUM

Рациональная фармакотерапия в кардиологии, 2015
Aim. To assess the effect of meldonium (in combination with antihypertensive therapy) on the severity of asthenic syndrome (AS) in elderly patients with arterial hypertension (HT).Material and methods.
M. E. Statsenko, S. V. Nedogoda, S. V. Turkina, I. A. Tyshchenko, L. V. Poletaeva, V. V. Tsoma, A. A. Ledyaeva, E. V. Chumachok   +7 more
doaj   +5 more sources

Meldonium: drug which brought disrepute to sport

International Journal of Basic & Clinical Pharmacology, 2017
World of sports have been rocked by doping scandals every now and then and World Anti-Doping Agency(WADA) has banned several offending drugs at different times to counter this menace. Meldonium is the recent addition to the long list of drugs banned by WADA to prevent its misuse among the athletes.
Bikash Ranjan Meher, Smita Das, Rashmi Ranjan Mohanty   +2 more
openaire   +3 more sources

ANTI-ISCHEMIC AND ANTIOXIDANT ACTIVITY OF MELDONIUM IN IHD PATIENTS WITH STABLE ANGINA

Медицинский совет, 2016
(IHD), stable angina of effort of functional class II (43 persons) – III (39 persons) (53.3±7.5 y.o., men - 71, women - 11), with concomitant arterial hypertension – in 21 patient.
V. P. MIKHIN, P. Y. TYURIKOV
doaj   +3 more sources

Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity

Pharmacological Research, 2016
Meldonium (mildronate; 3-(2,2,2-trimethylhydrazinium)propionate; THP; MET-88) is a clinically used cardioprotective drug, which mechanism of action is based on the regulation of energy metabolism pathways through l-carnitine lowering effect. l-Carnitine biosynthesis enzyme γ-butyrobetaine hydroxylase and carnitine/organic cation transporter type 2 ...
Maija Dambrova, Marina Makrecka-Kūka, Reinis Vilskersts   +2 more
exaly   +3 more sources

Letter to Editor: Potential Use of Meldonium as Supportive Treatment in Lifestyle Diseases

Journal of Education, Health and Sport
Meldonium, a drug more familiar in the sports world than in clinical medicine, acts as a structural analog of gamma-butyrobetaine and influences carnitine metabolism by inhibiting gamma-butyrobetaine hydroxylase. This results in reduced carnitine levels,
Magdalena Grzesiak, Oskar Szymański
doaj   +3 more sources