Results 61 to 70 of about 335 (142)

Studying the Efficacy of Vazonat in Comprehensive Treatment of Patients with Diabetes Mellitus Type 2

Mìžnarodnij Endokrinologìčnij Žurnal, 2016
The objective — to study the effectiveness of Vazonat (meldonium) in patients with diabetes mellitus (DM) type 2 in the comparative 12-week study. Materials and methods. The study involved 55 patients with DM type 2.
V.I. Pankiv
doaj   +1 more source

Meldonium: dotychczasowe i nowe możliwości terapeutyczne

Postępy Biochemii
Meldonium functions as an inhibitor of γ-butyrobetaine hydroxylase, the enzyme responsible for catalyzing the biosynthesis of L-carnitine. By inhibiting mitochondrial β-oxidation of fatty acids under hypoxic conditions, meldonium exerts cytoprotective effects on cardiac, hepatic, and pulmonary tissues.
Halszka Ponamarczuk, Marcin Popielarski
openaire   +1 more source

Experience with mildronate in cerebrovascular diseases

Медицинский совет, 2015
Over the past years, results of various clinical trials of drugs demonstrating their efficacy in the treatment of cardiovascular diseases have been published. The article discusses the results of clinical use of Mildronate (meldonium) in the treatment of
N. V. Pizova
doaj   +1 more source

Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity

Pharmacological Research, 2016
Meldonium (mildronate; 3-(2,2,2-trimethylhydrazinium)propionate; THP; MET-88) is a clinically used cardioprotective drug, which mechanism of action is based on the regulation of energy metabolism pathways through l-carnitine lowering effect. l-Carnitine biosynthesis enzyme γ-butyrobetaine hydroxylase and carnitine/organic cation transporter type 2 ...
Maija, Dambrova, Marina, Makrecka-Kuka, Reinis, Vilskersts, Elina, Makarova, Janis, Kuka, Edgars, Liepinsh   +5 more
openaire   +2 more sources

Features of meldonium effect on the cells viability and mitochondria of blood leucocytes in patients with angina pectoris

Acta Biomedica Scientifica
Background. The ambiguous effectiveness of cardiocytoprotectors and the low level of evidence for their use in coronary heart disease (CHD) necessitate the study of their direct effect on cell viability for assessing cytoprotective activity.The aim.
A. L. Khokhlov, O. V. Romashchenko, S. V. Nadezhdin, P. K. Alferov, L. V. Statsenko   +4 more
doaj   +1 more source

Crystal structures of binary compounds of meldonium 3-(1,1,1-trimethylhydrazin-1-ium-2-yl)propanoate with sodium bromide and sodium iodide

Acta Crystallographica Section E: Crystallographic Communications, 2018
3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoate (C6H14N2O2, M, more commonly known under its commercial names Meldonium or Mildronate) co-crystalizes with sodium bromide and sodium iodide forming polymeric hydrates poly[[tetra-μ-aqua-diaquabis[3-(1,1,1 ...
Alexander Y Nazarenko
doaj   +1 more source

Preventive cytoprotection in social diseases

Терапевтический архив, 2015
Among many cytoprotective drugs, only a few of them that have a targeted metabolic effect include agents that partially inhibit oxidation of free fatty acids, the so-called p-FOX inhibitors (partial fatty acid oxidation inhibitors). Aim.
A S Skotnikov, G N Gorokhovskaya, A M Shilov, V L Yun, M A Khamurzova   +4 more
doaj  

EFFECTIVENESS OF MELDONIUMIN IN CHRONIC HEART FAILURE PATIENTS

Медицинский совет, 2017
This article discusses the relevance of the high mortality of cardiovascular diseases (CVD) and their complications. Provides an overview of research conducted in the field of treatment of chronic heart failure and other cardiovascular diseases.
G. N. Gorokhovskaya, V. L. Yoon, A. S. Skotnikov, A. I. Martynov, E. Yu. Maychuk   +4 more
doaj   +1 more source

Chemoreactomic analysis of citrulline malate molecules

Неврология, нейропсихиатрия, психосоматика, 2017
Citrulline malate that is essential for the biosynthesis of arginine promotes dehydration of ammonium endotoxins, by participating in the urea cycle. The indications for the use of citrulline malate are functional asthenia, asthenic syndrome, overfatigue,
I. Yu. Torshin, O. A. Gromova, L. E. Fedotova, A. N. Gromov, K. V. Rudakov   +4 more
doaj   +1 more source

Post-COVID syndrome: status of carbohydrate metabolism in patients with hypertension and stable ischemic heart disease

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Post-COVID syndrome is associated with a wide range of chronic symptoms or conditions. Coronavirus di­sease 2019 (COVID-19) causes metabolic disorders such as hyperglycemia, insulin resistance.
O.V. Kuryata, O.S. Mytrokhina, Yu.S. Kushnir, O.I. Stadnyk   +3 more
doaj   +1 more source