Results 81 to 90 of about 34,274 (165)

Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids. [PDF]

, 2019
Tramadol is one of the most commonly used analgesics worldwide, classified as having a low abuse potential by U.S. Drug Enforcement Agency, and often recommended in pain management guidelines.
Abagyan, Ruben, Atayee, Rabia S, Makunts, Tigran, U, Andrew   +3 more
core   +1 more source

The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? [PDF]

, 2009
Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons.
Elgoyhen, Ana Belen, Fuchs, Paul A., Katz, Eleonora   +2 more
core   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Development and Validation of a Simple UV–HPLC Method to Quantify the Memantine Drug Used in Alzheimer’s Treatment

Pharmaceuticals
Memantine, a non-competitive NMDA receptor antagonist, is used to treat Alzheimer’s disease. Therefore, loading memantine in nanoparticles (NPs) could be an essential tool to improve the treatment effectiveness while reducing drug toxicity.
Débora Nunes, Tânia G. Tavares, Frenacisco Xavier Malcata, Joana A. Loureiro, Maria Carmo Pereira   +4 more
doaj   +1 more source

Behavioral assessment of antidepressant activity of Memantine - a NMDA receptor antagonist in animal models: An experimental study

National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: Around 5–10% of patients on selective serotonin reuptake inhibitors discontinue therapy because of side effects. Therefore, research for newer antidepressants with greater effectiveness has to be explored.
Harish G Bagewadi, Rajeshwari, Banderao V Patil   +2 more
doaj   +1 more source

Glutamatergic-dopaminergic balance in the brain. Its importance in motor disorders and schizophrenia [PDF]

, 1992
Dopamine appears to be of less importance in the regulation of psychomotor functions than was previously thought. A central dopaminergic-glutamatergic balance may be important for both akinetic motor disorders and psychosis.
Danielczyk, W., Kornhuber, J., Lange, Klaus W., Riederer, Peter   +3 more
core  

A clickable oxysterol photolabel retains NMDA receptor activity and accumulates in neurons [PDF]

, 2018
Oxysterol analogs that modulate NMDA receptor function are candidates for therapeutic development to treat neuropsychiatric disorders. However, the cellular actions of these compounds are still unclear.
Benz, Ann, Chen, Daniel M, Covey, Douglas F, Mennerick, Steven, Qian, Mingxing, Ziolkowski, Luke, Zorumski, Charles F   +6 more
core   +3 more sources

Effect of Renal Impairment on the Pharmacokinetics of Memantine

Journal of Pharmacological Sciences, 2012
The effect of renal impairment on the pharmacokinetics of a single oral dose of memantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL/min,
Takashi Moritoyo, Tomoko Hasunuma, Kazuhiro Harada, Tomonori Tateishi, Makoto Watanabe, Tsutomu Kotegawa, Masahiro Nagai, Yuji Kumagai, Tomomichi Fujitani, Takahumi Okura, Tomikazu Fukuoka, Kenichi Miyoshi, Bunzo Matsuura, Shinya Furukawa, Tomoe Kobori, Hiroyoko Moritoyo, Noriko Nishikawa, Tomoaki Tsujii, Hirotaka Iwaki, Masahiko Nakamura, Satoshi Makino, Kei Ohnuma, Koichiro Yuji, Megumi Hashimoto, Masaru Takasu, Yutaka Hashizume, Koji You, Tomoko Matsumura, Yuji Tanaka, Nahoko Matsumoto, Junichi Nakamura, Jun Miura, Tadao Akizawa, Kozo Kitazawa, Takanori Shibata, Aki Kuroki, Hirokazu Honda, Masanori Mukai, Kyoichi Ohashi, Takuya Morimoto, Hiromitsu Imai, Toshiaki Okudaira, Fuminori Sato, Junko Imanaga, Katsuhiro Tanaka, Masahiro Nomoto   +45 more
doaj   +1 more source

New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]

, 2014
There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P., Stavenhagen, Jeffrey B., Teeling, Jessica L.   +2 more
core   +3 more sources

Dynamic Alterations of Functional Systems in Alzheimer's Disease: A Co‐Activation Pattern Analysis

Human Brain Mapping, Volume 47, Issue 5, 1 April 2026.
State 3 exhibited significantly reduced persistence and resilience in both MCI and AD compared to CU. Individuals with MCI and AD showed reduced transition probability from State 2 to State 5 and decreased self‐transitions in State 3. Graph theoretical results corresponded well to the findings of the above CAP analysis.
Pan Wang, Mengfan Xue, Yingyin Mao, Chunyan Wang, Xing Yao, Bharat B. Biswal   +5 more
wiley   +1 more source