CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex [PDF]
Brain SciencesCerebral amyloid angiopathy is characterized by a weakening of the small- and medium-sized cerebral arteries, as their smooth muscle cells are progressively replaced with acellular amyloid β, increasing vessel fragility and vulnerability to ...
Carson D. Whinnery +4 more
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CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex. [PDF]
Sci Rep, 2019 Age Related Macular Degeneration (AMD) is the first cause of social blindness in people aged over 65 leading to atrophy of retinal pigment epithelial cells (RPE), photoreceptors and choroids, eventually associated with choroidal neovascularization ...
Borras C +14 more
europepmc +2 more sources
Reduced membrane attack complex formation in umbilical cord blood during Eculizumab treatment of the mother: a case report [PDF]
BMC Nephrology, 2019 Background Atypical hemolytic uremic syndrome (aHUS) is a disorder of the microvasculature with hemolytic anemia, thrombocytopenia and acute kidney injury.
Subagini Nagarajah +7 more
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An Ancient Molecular Arms Race: Chlamydia vs. Membrane Attack Complex/Perforin (MACPF) Domain Proteins [PDF]
Frontiers in Immunology, 2020 Dynamic interactions that govern the balance between host and pathogen determine the outcome of infection and are shaped by evolutionary pressures. Eukaryotic hosts have evolved elaborate and formidable defense mechanisms that provide the basis for ...
Gabrielle Keb, Kenneth A. Fields
doaj +2 more sources
Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System [PDF]
Frontiers in Immunology, 2020 The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi +5 more
doaj +2 more sources
Membrane Attack Complex in Myocardial Ischemia/Reperfusion Injury: A Systematic Review for Post Mortem Applications [PDF]
Diagnostics, 2020 The complement system has a significant role in myocardial ischemia/reperfusion injury, being responsible for cell lysis and amplification of inflammatory response.
Cristina Mondello +6 more
doaj +2 more sources
Programmable membrane attack complex
Biophysical Journal, 2022 Wachara Chanakul +2 more
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Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex. [PDF]
Front Immunol, 2018 Although neglected in the past, the interest on Zika virus (ZIKV) raised dramatically in the last several years. The rapid spread of the virus in Latin America and the association of the infection with microcephaly in newborns or Guillain-Barré Syndrome ...
Schiela B +12 more
europepmc +2 more sources
The membrane attack complex as an inflammatory trigger
Immunobiology, 2016 The final common pathway of all routes of complement activation involves the non-enzymatic assembly of a complex comprising newly formed C5b with the plasma proteins C6, C7, C8 and C9. When assembly occurs on a target cell membrane the forming complex inserts into and through the bilayer to create a pore, the membrane attack complex (MAC).
B. Morgan
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The Membrane Attack Complex in Aging Human Choriocapillaris
The American Journal of Pathology, 2014 Age-related macular degeneration (AMD) is a common disease that can result in severe visual impairment. Abnormal regulation of the complement system has been implicated in its pathogenesis, and CFH polymorphisms contribute substantially to risk.
Mullins, Robert F. +8 more
openaire +2 more sources