Results 191 to 200 of about 710,495 (352)

Soluble forms of membrane cofactor protein (CD46, MCP) are present in plasma, tears, and seminal fluid in normal subjects [PDF]

, 1992
Tomoko Hara, Shinichi Kuriyama, Hisakazu Kiyohara, Yasukazu Nagase, Misako Matsumoto, Tsukasa Seya   +5 more
openalex   +1 more source

Exposure Experiments to Test the Kinetic Stability of 5‐Hydroxymethylfurfural Oxidase (HMFO) in Different Reactor Environments

ChemCatChem, EarlyView.
Scaling beyond the laboratory exposes enzymes to new stresses. Exposure experiments reveal that dynamic gas‐liquid interfaces introduced by sparging or air entrainment during agitation are the main drivers of HMFO deactivation. Replacing bubbles with a membrane‐based bubble‐free aeration system dramatically enhances stability. These experiments provide
Amalie Vang Høst, Moritz Meyer, Patrick Bongratz, Marco W. Fraaije, John M. Woodley   +4 more
wiley   +1 more source

Fisetin as a Blueprint for Senotherapeutic Agents – Elucidating Geroprotective and Senolytic Properties with Molecular Modeling

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The exceptional senotherapeutic activity of fisetin, combining both geroprotective and senolytic effects, was validated using computational chemistry tools, establishing it as a cornerstone template for the development of novel agents. Abstract Targeting senescent cells and the factors that accelerate this pathological state has recently emerged as a ...
Maciej Spiegel
wiley   +1 more source

Molecular cloning of membrane cofactor protein (MCP; CD46) on B95a cell, an Epstein–Barr virus-transformed marmoset B cell line: B95a-MCP is susceptible to infection by the CAM, but not the Nagahata strain of the measles virus [PDF]

, 1998
Yusuke Murakami, Tsukasa Seya, M. Kurita, Aya Fukui, Shigeharu Ueda, Shigeharu Nagasawa   +5 more
openalex   +1 more source

Unveiling New Triazoloquinoxaline‐Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9

Chemistry – A European Journal, EarlyView.
We present new BRD9‐targeting degraders featuring a chemical warhead and E3 ligase ligand that distinctly differ from the typical chemical units used for BRD9 degradation. Specifically, we identified two VHL‐based PROTACs (2 and 9) based on a [1,2,4]triazolo[4,3‐a]quinoxaline scaffold that effectively and selectively degrade BRD9 and exhibit ...
Martina Pierri, Guglielmo Bove, Erica Gazzillo, Ester Colarusso, Francesca Scala, Giacomo Pepe, Stefania Terracciano, Maria Giovanna Chini, Nicla Simonelli, Ines Bruno, Angela Nebbioso, Pietro Campiglia, Giuseppe Bifulco, Lucia Altucci, Nunzio Del Gaudio, Gianluigi Lauro   +15 more
wiley   +1 more source

Do poor-prognosis breast tumours express membrane cofactor proteins (CD46)?

, 2004
Zahra Madjd, Lindy G. Durrant, Sarah E. Pinder, Ian O. Ellis, J Ronan, Sarah Lewis, Neil K. Rushmere, Ian Spendlove   +7 more
openalex   +2 more sources

Two Key Ferredoxins for Nitrogen Fixation Have Different Specificities and Biophysical Properties

Chemistry – A European Journal, EarlyView.
Two ferredoxins, FdC and FdN, are collectively essential for the process of nitrogen fixation by the iron nitrogenase in R. capsulatus. We explore the biophysical factors, through spectroscopic and structural characterizations, which determine ferredoxin functionality and pathway specificity. The structure of FdC (PDB: 9I2A) and model of FdN (AF‐D5ARY6)
Holly Addison, Pascal Pfister, Ana Lago‐Maciel, Tobias J. Erb, Antonio J. Pierik, Johannes G. Rebelein   +5 more
wiley   +1 more source

Transgenic Expression in Pig Hearts of Both Human Decay-Accelerating Factor and Human Membrane Cofactor Protein Does Not Provide an Additional Benefit to That of Human Decay-Accelerating Factor Alone in Pig-To-Baboon Xenotransplantation

, 2004
Rafael Máñez, E. López-Peláez, Alberto Centeno, José María Herrera, Alberto Juffé, Nieves Doménech, R. A. Harrison, Henk‐Jan Schuurman   +7 more
openalex   +1 more source

Molecular cloning of guinea pig membrane cofactor protein: preferential expression in testis. [PDF]

, 1996
Masato Hosokawa, Mayumi I. Nonaka, N Okada, Mayumi I. Nonaka, Haruhiko Okada   +4 more
openalex   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source