Results 201 to 210 of about 710,495 (352)

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, EarlyView.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

Faculty Opinions recommendation of Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis.

, 2004
John Atkinson
openalex   +2 more sources

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

Sustainable Synthesis, Characterization, Cellular Effects of Gold Nanoparticles and Their Applications as Therapeutics in Cancer Therapy

ChemPlusChem, EarlyView.
Gold nanoparticles (AuNPs) are widely used in biomedicine, electronics, catalysis, and environmental science. Conventional synthesis relies on harsh chemicals, driving interest in eco‐friendly methods using plants, bacteria, fungi, and algae. Biomolecules like polyphenols, proteins, and fatty acids aid nanoparticle synthesis under mild conditions. This
Youfeng Yue, Akihiro Moriyama, Marie Mita, Yue Yu   +3 more
wiley   +1 more source

The complement system in primary Sjögren’s syndrome: the expression of certain cascade and regulatory proteins in labial salivary glands – observational study

Rheumatology, 2020
Marta Legatowicz-Koprowska, Stanisław Nitek, Jolanta Czerwińska   +2 more
doaj   +1 more source

Controlling Lampenflora in Heritage Sites: In Situ Testing of Polyoxometalate–Ionic Liquids in the Pommery Champagne Cellar

ChemPlusChem, EarlyView.
The article evaluates polyoxometalate–ionic liquids (POM–ILs) as biocidal agents against lampenflora in the UNESCO‐listed Pommery Champagne cellar. POM–ILs effectively inhibit microbial colonization over one year with minimal visual impact and outperform the commercial biocide Preventol RI80.
Stéphanie Eyssautier‐Chuine, Ludovic Besaury, Nathalie Vaillant‐Gaveau, Sandra Villaume, Anouck Habrant, Isabel Franco‐Castillo, Marine Rondeau, Dina Aggad, Maxime Gommeaux, Gilles Fronteau, Scott G. Mitchell   +10 more
wiley   +1 more source

β‐Catenin localization in the ctenophore Mnemiopsis leidyi suggests an ancestral role in cell adhesion and nuclear function

Developmental Dynamics, EarlyView.
Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters, Lucas J. Guttieres, Mayline Goëb, Stanley J. Marjenberg, Mark Q. Martindale, Athula H. Wikramanayake   +5 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Molecular structure and free energy landscape for electron transport in the decahaem cytochrome MtrF [PDF]

, 2012
Blumberger, Breuer, Brown, Clarke, David J. Richardson, El-Naggar, Gorby, Hartshorne, James K. Fredrickson, Jensen, Jochen Blumberger, John M. Zachara, Julea N. Butt, Kevin M. Rosso, Liang Shi, Marcus J. Edwards, Marian Breuer, Moser, Myers, Piotr Zarzycki, Polizzi, Straub, Thomas A. Clarke, Tipmanee, Tipmanee, Xiong   +25 more
core   +1 more source