Results 251 to 260 of about 104,326 (289)

Ontogeny of membrane cofactor protein: phenotypic divergence in the fetal heart

Lupus, 1995
Human adult cells are protected from complement-induced damage in part by membrane cofactor protein (MCP, CD46). To examine fetal characteristics which might influence autoantibody-mediated diseases acquired in utero, such as heart block in neonatal lupus, the tissue expression of MCP was studied.
Jill Buyon
exaly   +3 more sources

Production and characterization of a pig line transgenic for human membrane cofactor protein

Xenotransplantation, 2002
A pig line transgenic for human membrane cofactor protein (hMCP) has been established. Offspring from the founder were produced by crossing the founder with pigs heterozygous for the human decay accelerating factor (hDAF) transgene. As a result, pigs transgenic for both hMCP and hDAF have been produced.
Chun-Yan, Zhou, Elizabeth, McInnes, Nicola, Parsons, Gillian, Langford, Richard, Lancaster, Andrew, Richards, Gilda, Pino-Chavez, Gabriela, Dos Santos Cruz, Laura, Copeman, Christine, Carrington, Simon, Thompson   +10 more
exaly   +3 more sources

Membrane targeting of a folded and cofactor‐containing protein

European Journal of Biochemistry, 2003
Targeting of proteins to and translocation across the membranes is a fundamental biological process in all organisms. In bacteria, the twin arginine translocation (Tat) system can transport folded proteins. Here, we demonstrate in vivo that the high potential iron‐sulfur protein (HiPIP) from Allochromatium vinosum is translocated into the periplasmic ...
Thomas, Brüser, Takahiro, Yano, Daniel C, Brune, Fevzi, Daldal   +3 more
openaire   +2 more sources

Identification and characterization of membrane cofactor protein of human spermatozoa

The Journal of Immunology, 1992
Abstract Membrane cofactor protein (MCP) regulates C activation by serving as a cofactor for the cleavage of C3b and C4b by the serine protease factor I. An MCP-like molecule on the inner acrosomal membrane of human spermatozoa has been characterized. Three mAb and a rabbit polyclonal antibody against MCP recognized the sperm protein.
F, Cervoni, T J, Oglesby, E M, Adams, C, Milesifluet, M, Nickells, P, Fenichel, J P, Atkinson, B L, Hsi   +7 more
openaire   +2 more sources

Membrane cofactor protein

1992
MCP serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor for the factor I-mediated cleavage of C3b and C4b. MCP is most likely an intrinsic regulator, i.e., it primarily protects its home cell.
M K, Liszewski, J P, Atkinson
openaire   +2 more sources

Decay-Accelerating Factor and Membrane Cofactor Protein

1990
Cells exposed to plasma proteins are frequently under attack from the complement system. This can arise either as a bystander process to the classical or alternative pathways of activation initiated during the immune response to foreign particles and organisms or from the constant tick-over of the alternative pathway.
D M, Lublin, J P, Atkinson
openaire   +2 more sources

Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa

Molecular Reproduction and Development, 2000
AbstractMembrane cofactor protein (MCP; CD46) is a complement regulator widely expressed as four isoforms that arise via alternative splicing. On human spermatozoa, MCP is expressed on the inner acrosomal membrane and alterations of spermatozoa MCP may be associated with infertility.
Rebecca C, Riley, Claudia, Kemper, Marilyn, Leung, John P, Atkinson   +3 more
openaire   +2 more sources

Identification and characterization of membrane cofactor protein (CD46) in the human kidneys

European Journal of Immunology, 1994
AbstractMembrane cofactor protein (MCP, CD46) is an integral protein that serves as a cofactor for factor I in inactivating C3b/C4b deposited on the same cell‐membrane as C3bi/C4c+C4d. This C3b/C4b inactivation is closely associated with self‐protection of host cells from autologous complement attack.
Isao Nakanishi, Abdelhakim Moutabarrik, Tomoko Hara, Michiyo Hatanaka, Terumasa Hayashi, Tatsuya Syouji, Noriyuki Okada, Eisaku Kitamura, Yoshiharu Tsubakihara, Misako Matsumoto, Tsukasa Seya   +10 more
openaire   +2 more sources

Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity

The Journal of Immunology, 1991
Abstract Membrane cofactor protein (MCP) (CD46) of the C system binds to C3b and C4b, functions as a cofactor for their cleavage, and protects autologous cells from C-mediated injury. The predominant structural motif of MCP is the short consensus repeat (SCR), a repeating domain involved in ligand binding of other related C regulatory ...
E M, Adams, M C, Brown, M, Nunge, M, Krych, J P, Atkinson   +4 more
openaire   +2 more sources

Characterization of the promoter region of the membrane cofactor protein (CD46) gene of the human complement system and comparison to a membrane cofactor protein-like genetic element.

The Journal of Immunology, 1993
Abstract Membrane cofactor protein (MCP; CD46) is a widely expressed C regulatory protein that inhibits C activation on self-tissue. MCP binds C3b and C4b deposited on autologous cells and then serves as a cofactor for their inactivation by limited proteolytic cleavage.
W, Cui, D, Hourcade, T, Post, A C, Greenlund, J P, Atkinson, V, Kumar   +5 more
openaire   +2 more sources