Results 261 to 270 of about 104,326 (289)

Human membrane cofactor protein (MCP, CD46): multiple isoforms and functions

The International Journal of Biochemistry & Cell Biology, 1999
Human membrane cofactor protein (MCP, CD46) is a 45-70 kDa protein with genetic and tissue-specific heterogeneity, and is expressed on all nucleated cells. MCP consists from N-terminus of 4 short consensus repeats (SCRs), 1-3 serine/threonine-rich (ST) domains, a transmembrane domain (TM) and a cytoplasmic tail (CYT). More than 8 isoforms are generated
T, Seya, A, Hirano, M, Matsumoto, M, Nomura, S, Ueda   +4 more
openaire   +2 more sources

Glycosylation of membrane cofactor protein (CD46) in human trophoblast, kidney and platelets

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1992
Many cell surface glycoconjugates are differentiation markers and are involved in cell-cell and intermolecular interactions in development, immunity and cancer. Membrane cofactor protein (MCP) comprises structurally related 65 and 55 kDa glycoproteins that bear O- and N-linked glycans. MCP prevents amplification of autologous complement action on human
O A, Vanderpuye, C A, Labarrere, J A, McIntyre   +2 more
openaire   +2 more sources

Membrane Attack Complex and Membrane Cofactor Protein Are Related to Tubulointerstitial Inflammation in Various Human Glomerulopathies

Nephron, 2008
Immunohistochemical analysis of the membrane attack complex (MAC) and the membrane cofactor protein (MCP) was performed on the tubuli and cortical vessels of 46 kidney biopsies with various types of human glomerulopathies. Irrespective of the type of glomerulopathy, significant correlations between tubular MAC and interstitial lymphomonocyte ...
S, Mosolits, T, Magyarlaki, J, Nagy
openaire   +2 more sources

Molecular cloning of guinea pig membrane cofactor protein: preferential expression in testis

The Journal of Immunology, 1996
Abstract Human membrane cofactor protein (MCP) is a widely distributed cell-associated complement-regulatory protein, and recent findings suggest that MCP may be involved in sperm-egg interaction. We have isolated four cDNA clones and one reverse transcriptase-PCR product homologous to human MCP from guinea pig testis.
M, Hosokawa, M, Nonaka, N, Okada, M, Nonaka, H, Okada   +4 more
openaire   +2 more sources

Expression and significance of leukocyte membrane cofactor protein transcript in systemic lupus erythematosus

Lupus, 2012
Membrane cofactor protein (MCP) is a complement regulatory protein ubiquitously expressed on most nucleated cells. Since MCP protects autologous cells from complement-mediated injury, it is suggested to have a protective role against the self-tissue damage in inflammatory conditions such as systemic lupus erythematosus (SLE).
B, Biswas, U, Kumar, N, Das
openaire   +2 more sources

CD46 (Membrane Cofactor Protein, MCP)

1998
M.Kathryn Liszewski, John P. Atkinson
openaire   +1 more source

Genomic analysis of the murine membrane cofactor protein (CD46)

Molecular Immunology, 1998
M. Nomura, A. Tsujimura, K. Shida, M. Matsumoto, Y. Matsuda, T. Seya   +5 more
openaire   +1 more source

Elevated serum levels of soluble membrane cofactor protein (CD46, MCP) in patients with systemic lupus erythematosus (SLE)

Clinical and Experimental Immunology, 2001
Tsukasa Seya, Mitsuhiro Kawano, Kawano M   +2 more
exaly  

[Membrane cofactor protein (MCP, CD46)].

Nihon rinsho. Japanese journal of clinical medicine, 2000
T, Seya, M, Taniguchi, M, Matsumoto
openaire   +1 more source

Immunohistochemical demonstration of membrane cofactor protein (MCP) of complement in normal and diseased kidney tissues

Clinical and Experimental Immunology, 2008
John Atkinson, H Ohi, Okada H
exaly