Results 11 to 20 of about 29,208 (221)
Sphingolipids: membrane microdomains in brain development, function and neurological diseases [PDF]
Open Biology, 2017 Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as
Anne S. B. Olsen, Nils J. Færgeman
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Analysis of lipid-composition changes in plasma membrane microdomains[S] [PDF]
Journal of Lipid Research, 2015 Sphingolipids accumulate in plasma membrane microdomain sites, such as caveolae or lipid rafts. Such microdomains are considered to be important nexuses for signal transduction, although changes in the microdomain lipid components brought about by ...
Hideo Ogiso +2 more
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Spatio-temporal remodeling of functional membrane microdomains organizes the signaling networks of a bacterium. [PDF]
PLoS Genetics, 2015 Lipid rafts are membrane microdomains specialized in the regulation of numerous cellular processes related to membrane organization, as diverse as signal transduction, protein sorting, membrane trafficking or pathogen invasion.
Johannes Schneider +8 more
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Functional microdomains in bacterial membranes [PDF]
Genes & Development, 2010 The membranes of eukaryotic cells harbor microdomains known as lipid rafts that contain a variety of signaling and transport proteins. Here we show that bacterial membranes contain microdomains functionally similar to those of eukaryotic cells. These membrane microdomains from diverse bacteria harbor homologs of Flotillin-1, a eukaryotic protein found ...
López, Daniel, Kolter, Roberto
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The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts". [PDF]
PLoS ONE, 2012 BACKGROUND: The importance of membrane compartmentalization into specific membrane microdomains has been shown in many biological processes such as immunoreceptor signaling, membrane trafficking, pathogen infection, and tumor progression.
Matous Hrdinka +2 more
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Tight junctions are membrane microdomains [PDF]
Journal of Cell Science, 2000 ABSTRACT Tight junctions (TJ) of polarized epithelial cells regulate barrier function at mucosal surfaces. Structural proteins of TJs include hyperphosphorylated occludin (HO) and the peripheral membrane protein, ZO-1. Since TJs are dynamically regulated, and lipid-modified signal transduction proteins localize to TJs, we considered the ...
A, Nusrat +7 more
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The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains
eLife, 2021 Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum (ER) protein. S1R modulates activity of multiple effector proteins and is a well-established drug target.
Vladimir Zhemkov +6 more
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Membrane microdomains in immunoreceptor signaling [PDF]
FEBS Letters, 2014 Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicated in T‐cell receptor (TCR), and more generally immunoreceptor, signaling for over 25 years. However, this area of research has been complicated by doubts about the real nature (and even existence) of these membrane entities, especially because of methodological
Horejsi, Vaclav, Hrdinka, Matous
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Journal of Lipid Research, 2001 The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that ...
Howard S. Kruth +5 more
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Reversible Dissolution of Microdomains in Detergent-Resistant Membranes at Physiological Temperature. [PDF]
PLoS ONE, 2015 The formation of lipid microdomains ("rafts") is presumed to play an important role in various cellular functions, but their nature remains controversial.
Andrea Cremona +4 more
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