Results 31 to 40 of about 34,175 (279)
Multiple Kv1.5 targeting to membrane surface microdomains [PDF]
Journal of Cellular Physiology, 2008 AbstractSurface expression of voltage‐dependent K+ channels (Kv) has a pivotal role in leukocyte physiology. Although little is known about the physiological role of lipid rafts, these microdomains concentrate signaling molecules and their ion channel substrates. Kv1.3 associates with Kv1.5 to form functional channels in macrophages.
Martinez-Marmol, Ramon +6 more
openaire +8 more sources
Cells, 2013 The dynamic interplay among intracellular organelles occurs at specific membrane tethering sites, where two organellar membranes come in close apposition but do not fuse.
Alessandra d'Azzo, Ida Annunziata
doaj +3 more sources
Photo‐Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA [PDF]
Advanced Science, 2020 Jie Hui, Pu-Ting Dong, Lijia Liang
exaly +2 more sources
Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections [PDF]
Cell Reports, 2020 Franziska Schmidt +2 more
exaly +2 more sources
The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts". [PDF]
PLoS ONE, 2012 BACKGROUND: The importance of membrane compartmentalization into specific membrane microdomains has been shown in many biological processes such as immunoreceptor signaling, membrane trafficking, pathogen infection, and tumor progression.
Matous Hrdinka +2 more
doaj +1 more source
Tight junctions are membrane microdomains [PDF]
Journal of Cell Science, 2000 ABSTRACT Tight junctions (TJ) of polarized epithelial cells regulate barrier function at mucosal surfaces. Structural proteins of TJs include hyperphosphorylated occludin (HO) and the peripheral membrane protein, ZO-1. Since TJs are dynamically regulated, and lipid-modified signal transduction proteins localize to TJs, we considered the ...
A, Nusrat +7 more
openaire +2 more sources
The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains
eLife, 2021 Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum (ER) protein. S1R modulates activity of multiple effector proteins and is a well-established drug target.
Vladimir Zhemkov +6 more
doaj +1 more source
Functional microdomains in bacterial membranes [PDF]
Genes & Development, 2010 The membranes of eukaryotic cells harbor microdomains known as lipid rafts that contain a variety of signaling and transport proteins. Here we show that bacterial membranes contain microdomains functionally similar to those of eukaryotic cells. These membrane microdomains from diverse bacteria harbor homologs of Flotillin-1, a eukaryotic protein found ...
López, Daniel, Kolter, Roberto
openaire +4 more sources
CD317/Tetherin is an organiser of membrane microdomains [PDF]
Journal of Cell Science, 2013 The integral membrane protein tetherin has been associated with an eclectic mix of cellular processes, including restricting the release of a range of enveloped viruses from infected cells. The unusual topology of tetherin (it possesses both a conventional transmembrane domain and a glycosylphosphatidylinositol anchor), its localisation to membrane ...
Billcliff, Peter G. +5 more
openaire +3 more sources
Journal of Lipid Research, 2001 The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that ...
Howard S. Kruth +5 more
doaj +1 more source