Results 11 to 20 of about 1,117,893 (276)
Membrane microdomains in immunoreceptor signaling [PDF]
FEBS Letters, 2014 Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicated in T‐cell receptor (TCR), and more generally immunoreceptor, signaling for over 25 years. However, this area of research has been complicated by doubts about the real nature (and even existence) of these membrane entities, especially because of methodological
Horejsi, Vaclav, Hrdinka, Matous
openaire +4 more sources
Membrane microdomains and insulin resistance [PDF]
FEBS Letters, 2009 A new concept, that “metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides”, has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides ...
Inokuchi, Jin-ichi
openaire +4 more sources
Organization and dynamics of functional plant membrane microdomains. [PDF]
Cell Mol Life Sci, 2020 Plasma membranes are heterogeneous and laterally compartmentalized into distinct microdomains. These membrane microdomains consist of special lipids and proteins and are thought to act as signaling platforms. In plants, membrane microdomains have been detected by super-resolution microscopy, and there is evidence that they play roles in several ...
Yu M, Cui Y, Zhang X, Li R, Lin J.
europepmc +3 more sources
Membrane-Sculpting BAR Domains Generate Stable Lipid Microdomains [PDF]
Cell Reports, 2013 Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations.
Hongxia Zhao +6 more
doaj +2 more sources
Sphingolipids: membrane microdomains in brain development, function and neurological diseases [PDF]
Open Biology, 2017 Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as
Anne S. B. Olsen, Nils J. Færgeman
doaj +2 more sources
Molecular mechanisms of flotillin complexes in organizing membrane microdomains [PDF]
Nature CommunicationsFlotillin-1 and flotillin-2 form hetero-oligomers to create flotillin membrane microdomains essential for endocytosis and protein sorting. However, the mechanisms of flotillin oligomerization and microdomain organization remain incompletely understood ...
Ming-Ao Lu +7 more
doaj +2 more sources
Lck, membrane microdomains and TCR triggering machinery: defining the new rules of engagement
Frontiers in Immunology, 2012 In spite of a comprehensive understanding of the schematics of T cell receptor (TCR) signaling, the mechanisms regulating compartmentalization of signaling molecules, their transient interactions and rearrangement of membrane structures initiated upon ...
Dominik eFilipp +2 more
doaj +3 more sources
Exploring functional membrane microdomains in bacteria: an overview. [PDF]
Curr Opin Microbiol, 2017 Recent studies show that internal organization of bacterial cells is more complex than previously appreciated. A clear example of this is the assembly of the nanoscale membrane platforms termed functional membrane microdomains. The lipid composition of these regions differs from that of the surrounding membrane; these domains confine a set of proteins ...
Lopez D, Koch G.
europepmc +4 more sources
Adenosine receptors and membrane microdomains [PDF]
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011 Adenosine receptors are a member of the large family of seven transmembrane spanning G protein coupled receptors. The four adenosine receptor subtypes-A(1), A(2a), A(2b), A(3)-exert their effects via the activation of one or more heterotrimeric G proteins resulting in the modulation of intracellular signaling. Numerous studies over the past decade have
Lasley, Robert D., Robert D. Lasley
openaire +3 more sources
Cells, 2013 The dynamic interplay among intracellular organelles occurs at specific membrane tethering sites, where two organellar membranes come in close apposition but do not fuse.
Alessandra d'Azzo, Ida Annunziata
doaj +3 more sources