FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains [PDF]
Scientific Reports, 2017 Platelet-derived growth factor receptor (PDGFR) senses extracellular growth factors and transfer the signals inside the cells regulating cell proliferation, migration and survival.
Jihye Seong +4 more
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Sphingolipids: membrane microdomains in brain development, function and neurological diseases [PDF]
Open Biology, 2017 Sphingolipids are highly enriched in the nervous system where they are pivotal constituents of the plasma membranes and are important for proper brain development and functions. Sphingolipids are not merely structural elements, but are also recognized as
Anne S. B. Olsen, Nils J. Færgeman
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Molecular mechanisms of flotillin complexes in organizing membrane microdomains [PDF]
Nature CommunicationsFlotillin-1 and flotillin-2 form hetero-oligomers to create flotillin membrane microdomains essential for endocytosis and protein sorting. However, the mechanisms of flotillin oligomerization and microdomain organization remain incompletely understood ...
Ming-Ao Lu +7 more
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Plant Hormones Differentially Control the Sub-Cellular Localization of Plasma Membrane Microdomains during the Early Stage of Soybean Nodulation. [PDF]
Genes (Basel), 2019 Phytohormones regulate the mutualistic symbiotic interaction between legumes and rhizobia, nitrogen-fixing soil bacteria, notably by controlling the formation of the infection thread in the root hair (RH).
Qiao Z, Zogli P, Libault M.
europepmc +3 more sources
Photo-Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA. [PDF]
Adv Sci (Weinh), 2020 Hui J +12 more
europepmc +2 more sources
Spatio-temporal remodeling of functional membrane microdomains organizes the signaling networks of a bacterium. [PDF]
PLoS Genetics, 2015 Lipid rafts are membrane microdomains specialized in the regulation of numerous cellular processes related to membrane organization, as diverse as signal transduction, protein sorting, membrane trafficking or pathogen invasion.
Johannes Schneider +8 more
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Functional microdomains in bacterial membranes [PDF]
Genes & Development, 2010 The membranes of eukaryotic cells harbor microdomains known as lipid rafts that contain a variety of signaling and transport proteins. Here we show that bacterial membranes contain microdomains functionally similar to those of eukaryotic cells. These membrane microdomains from diverse bacteria harbor homologs of Flotillin-1, a eukaryotic protein found ...
López, Daniel, Kolter, Roberto
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The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts". [PDF]
PLoS ONE, 2012 BACKGROUND: The importance of membrane compartmentalization into specific membrane microdomains has been shown in many biological processes such as immunoreceptor signaling, membrane trafficking, pathogen infection, and tumor progression.
Matous Hrdinka +2 more
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Tight junctions are membrane microdomains [PDF]
Journal of Cell Science, 2000 ABSTRACT Tight junctions (TJ) of polarized epithelial cells regulate barrier function at mucosal surfaces. Structural proteins of TJs include hyperphosphorylated occludin (HO) and the peripheral membrane protein, ZO-1. Since TJs are dynamically regulated, and lipid-modified signal transduction proteins localize to TJs, we considered the ...
A, Nusrat +7 more
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The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains
eLife, 2021 Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum (ER) protein. S1R modulates activity of multiple effector proteins and is a well-established drug target.
Vladimir Zhemkov +6 more
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