Membrane microdomains in immunoreceptor signaling [PDF]
FEBS Letters, 2014 Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicated in T‐cell receptor (TCR), and more generally immunoreceptor, signaling for over 25 years. However, this area of research has been complicated by doubts about the real nature (and even existence) of these membrane entities, especially because of methodological
Horejsi, Vaclav, Hrdinka, Matous
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Nanoclustering as a dominant feature of plasma membrane organization [PDF]
, 2014 Early studies have revealed that some mammalian plasma membrane proteins exist in small nanoclusters. The advent of super-resolution microscopy has corroborated and extended this picture, and led to the suggestion that many, if not most, membrane ...
Cambi, Alessandra +4 more
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Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology. [PDF]
, 2016 Trypanosoma cruzi, the flagellate protozoan agent of Chagas disease or American trypanosomiasis, is unable to synthesize sialic acids de novo. Mucins and trans-sialidase (TS) are substrate and enzyme, respectively, of the glycobiological system that ...
A Acosta-Serrano +83 more
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Journal of Lipid Research, 2001 The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that ...
Howard S. Kruth +5 more
doaj +1 more source
Manipulation of lipid rafts in neuronal cells [PDF]
, 2010 Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
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Reversible Dissolution of Microdomains in Detergent-Resistant Membranes at Physiological Temperature. [PDF]
PLoS ONE, 2015 The formation of lipid microdomains ("rafts") is presumed to play an important role in various cellular functions, but their nature remains controversial.
Andrea Cremona +4 more
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Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation [PDF]
, 2016 Mitochondria-associated membranes (MAMs) are subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. This membrane scrambling between ER and mitochondria appears to play a critical role in the earliest steps of autophagy.
Faggioni, Alberto +9 more
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Contributions of quantitative proteomics to understanding membrane microdomains
Journal of Lipid Research, 2009 Membrane microdomains, e.g., lipid rafts and caveolae, are crucial cell surface organelles responsible for many cellular signaling and communication events, which makes the characterization of their proteomes both interesting and valuable. They are large
Yu Zi Zheng, Leonard J. Foster
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T cell Ca2+ microdomains through the lens of computational modeling
Frontiers in Immunology, 2023 Cellular Ca2+ signaling is highly organized in time and space. Locally restricted and short-lived regions of Ca2+ increase, called Ca2+ microdomains, constitute building blocks that are differentially arranged to create cellular Ca2+ signatures ...
Diana C. Gil Montoya +4 more
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Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton [PDF]
, 1999 CD44, the major cell surface receptor for hyaluronic acid (HA), was shown to localize to detergent-resistant cholesterol-rich microdomains, called lipid rafts, in fibroblasts and blood cells.
Oliferenko, S. +8 more
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