Results 21 to 30 of about 34,175 (279)
Host cell membrane microdomains and fungal infection. [PDF]
Cell Microbiol, 2021 Lipid microdomains or lipid rafts are dynamic and tightly ordered regions of the plasma membrane. In mammalian cells, they are enriched in cholesterol, glycosphingolipids, Glycosylphosphatidylinositol-anchored and signalling-related proteins. Several studies have suggested that mammalian pattern recognition receptors are concentrated or recruited to ...
Souza TN +6 more
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Membrane microdomains and insulin resistance [PDF]
FEBS Letters, 2009 A new concept, that “metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides”, has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides ...
Inokuchi, Jin-ichi
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Spatio-temporal remodeling of functional membrane microdomains organizes the signaling networks of a bacterium. [PDF]
PLoS Genetics, 2015 Lipid rafts are membrane microdomains specialized in the regulation of numerous cellular processes related to membrane organization, as diverse as signal transduction, protein sorting, membrane trafficking or pathogen invasion.
Johannes Schneider +8 more
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Stepping between membrane microdomains. [PDF]
Biophys J, 2015 Lateral membrane microdomains are postulated to be involved in a number of important functions in mammalian cells, such as membrane trafficking, exocytosis, endocytosis, signal transduction, and protein activity (1,2). These putative cell microdomains have been the subject of extensive research using a variety of biophysical and biochemical techniques,
McIntosh TJ.
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Membrane-Sculpting BAR Domains Generate Stable Lipid Microdomains [PDF]
Cell Reports, 2013 Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations.
Hongxia Zhao +6 more
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Organization and dynamics of functional plant membrane microdomains. [PDF]
Cell Mol Life Sci, 2020 Plasma membranes are heterogeneous and laterally compartmentalized into distinct microdomains. These membrane microdomains consist of special lipids and proteins and are thought to act as signaling platforms. In plants, membrane microdomains have been detected by super-resolution microscopy, and there is evidence that they play roles in several ...
Yu M, Cui Y, Zhang X, Li R, Lin J.
europepmc +3 more sources
Molecular mechanisms of flotillin complexes in organizing membrane microdomains [PDF]
Nature CommunicationsFlotillin-1 and flotillin-2 form hetero-oligomers to create flotillin membrane microdomains essential for endocytosis and protein sorting. However, the mechanisms of flotillin oligomerization and microdomain organization remain incompletely understood ...
Ming-Ao Lu +7 more
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Adenosine receptors and membrane microdomains
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011 Adenosine receptors are a member of the large family of seven transmembrane spanning G protein coupled receptors. The four adenosine receptor subtypes-A(1), A(2a), A(2b), A(3)-exert their effects via the activation of one or more heterotrimeric G proteins resulting in the modulation of intracellular signaling. Numerous studies over the past decade have
Lasley, Robert D., Robert D. Lasley
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Exploring functional membrane microdomains in bacteria: an overview. [PDF]
Curr Opin Microbiol, 2017 Recent studies show that internal organization of bacterial cells is more complex than previously appreciated. A clear example of this is the assembly of the nanoscale membrane platforms termed functional membrane microdomains. The lipid composition of these regions differs from that of the surrounding membrane; these domains confine a set of proteins ...
Lopez D, Koch G.
europepmc +4 more sources
Lck, membrane microdomains and TCR triggering machinery: defining the new rules of engagement
Frontiers in Immunology, 2012 In spite of a comprehensive understanding of the schematics of T cell receptor (TCR) signaling, the mechanisms regulating compartmentalization of signaling molecules, their transient interactions and rearrangement of membrane structures initiated upon ...
Dominik eFilipp +2 more
doaj +3 more sources