Results 21 to 30 of about 29,208 (221)

Contributions of quantitative proteomics to understanding membrane microdomains

Journal of Lipid Research, 2009
Membrane microdomains, e.g., lipid rafts and caveolae, are crucial cell surface organelles responsible for many cellular signaling and communication events, which makes the characterization of their proteomes both interesting and valuable. They are large
Yu Zi Zheng, Leonard J. Foster
doaj   +1 more source

T cell Ca2+ microdomains through the lens of computational modeling

Frontiers in Immunology, 2023
Cellular Ca2+ signaling is highly organized in time and space. Locally restricted and short-lived regions of Ca2+ increase, called Ca2+ microdomains, constitute building blocks that are differentially arranged to create cellular Ca2+ signatures ...
Diana C. Gil Montoya, Roberto Ornelas-Guevara, Björn-Philipp Diercks, Andreas H. Guse, Geneviève Dupont   +4 more
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Use of dansyl-cholestanol as a probe of cholesterol behavior in membranes of living cells[S]

Journal of Lipid Research, 2010
While plasma membrane cholesterol-rich microdomains play a role in cholesterol trafficking, little is known about the appearance and dynamics of cholesterol through these domains in living cells.
Huan Huang, Avery L. McIntosh, Barbara P. Atshaves, Yoshiko Ohno-Iwashita, Ann B. Kier, Friedhelm Schroeder   +5 more
doaj   +1 more source

Glycosphingolipid GM3 is localized in both exoplasmic and cytoplasmic leaflets of Plasmodium falciparum malaria parasite plasma membrane

Scientific Reports, 2021
Lipid rafts, sterol-rich and sphingolipid-rich microdomains on the plasma membrane are important in processes like cell signaling, adhesion, and protein and lipid transport.
Shiomi Koudatsu, Tatsunori Masatani, Rikako Konishi, Masahito Asada, Hassan Hakimi, Yuna Kurokawa, Kanna Tomioku, Osamu Kaneko, Akikazu Fujita   +8 more
doaj   +1 more source

Caveolin is present in intestinal cells: role in cholesterol trafficking?

Journal of Lipid Research, 1998
It was postulated that specialized microdomains of the plasma membrane, consistent with caveolae, might play a role in cholesterol trafficking in intestinal cells.
F. Jeffrey Field, Ella Born, Shubha Murthy, Satya N. Mathur   +3 more
doaj   +1 more source

Membrane microdomains and insulin resistance [PDF]

FEBS Letters, 2009
A new concept, that “metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides”, has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides ...
openaire   +2 more sources

Membrane Microdomain Disassembly Inhibits MRSA Antibiotic Resistance [PDF]

Cell, 2017
A number of bacterial cell processes are confined functional membrane microdomains (FMMs), structurally and functionally similar to lipid rafts of eukaryotic cells. How bacteria organize these intricate platforms and what their biological significance is remain important questions.
Esther García-Fernández, Gudrun Koch, Rabea M. Wagner, Agnes Fekete, Stephanie T. Stengel, Johannes Schneider, Benjamin Mielich-Süss, Sebastian Geibel, Sebastian M. Markert, Christian Stigloher, Daniel Lopez   +10 more
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Tracking microdomain dynamics in cell membranes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009
Studies of the diffusion of proteins and lipids in the plasma membrane of cells have long pointed to the presence of membrane domains. A major challenge in the field of membrane biology has been to characterize the various cellular structures and mechanisms that impede free diffusion in cell membranes and determine the consequences that membrane ...
Day, Charles A., Kenworthy, Anne K.
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Multiple Kv1.5 targeting to membrane surface microdomains [PDF]

Journal of Cellular Physiology, 2008
AbstractSurface expression of voltage‐dependent K+ channels (Kv) has a pivotal role in leukocyte physiology. Although little is known about the physiological role of lipid rafts, these microdomains concentrate signaling molecules and their ion channel substrates. Kv1.3 associates with Kv1.5 to form functional channels in macrophages.
Martinez-Marmol, Ramon, Villalonga, Nuria, Sole, Laura, Vicente, Ruben, Tamkun, Michael M., Soler, Concepcio, Felipe, Antonio   +6 more
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Membrane Microdomains and Vascular Biology [PDF]

Circulation, 2003
The classic model of cell plasma membrane organization is that of a uniform, fluid environment in which protein and lipid constituents diffuse rapidly in an unrestricted fashion. Recent experimental evidence, however, reveals a far more complex membrane organization consisting of microdomains assembled from lipid constituents that have distinct ...
R Preston, Mason, Robert F, Jacob
openaire   +2 more sources