Results 101 to 110 of about 395,750 (308)

Monoclonal antibody detection of plasma membrane cholesterol microdomains responsive to cholesterol trafficking

Journal of Lipid Research, 2001
The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that ...
Howard S. Kruth, Ina Ifrim, Janet Chang, Lia Addadi, Daniele Perl-Treves, Wei-Yang Zhang   +5 more
doaj   +1 more source

Innate immunity signalling and membrane trafficking

Current Opinion in Cell Biology, 2019
The mammalian innate immune system serves as the front line of the host to eliminate invading pathogens. The receptors that sense invading pathogens or the pathogen-associated molecules localized at various membrane compartments that include the plasma membrane, endosomes, and the endoplasmic reticulum. Intriguingly, growing evidence indicates that the
Tomohiko, Taguchi, Kojiro, Mukai
openaire   +2 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Membrane trafficking in neurodevelopmental disorders – new insight and therapeutic implications

Journal of Education, Health and Sport
Introduction: Membrane trafficking processes are essential for cell viability and basic functions, as well as for interactions between the cell interior and the surrounding environment. Purpose: This article focuses on the review of specific subgroup
Małgorzata Pawłowicz
doaj   +1 more source

Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane

Neurobiology of Disease, 2018
Inhibition of mitochondrial axonal trafficking by amyloid beta (Aβ) peptides has been implicated in early pathophysiology of Alzheimer's Disease (AD).
Liang Zhang, Sergey Trushin, Trace A. Christensen, Utkarsh Tripathi, Courtney Hong, Rachel E. Geroux, Kyle G. Howell, Joseph F. Poduslo, Eugenia Trushina   +8 more
doaj   +1 more source

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]

, 2016
Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching, Chen, Tsung-Yu, Hsieh, Hsin-Ying, Huang, Jing-Jia, Peng, Yi-Jheng, Tang, Chih-Yung, Wu, Chia-Ying, Wu, Hao-Han   +7 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

Nature Communications
Retromer mediates endosomal retrieval of transmembrane proteins in all eukaryotes and was first discovered in yeast in complex with the Vps5 and Vps17 sorting nexins (SNXs).
Kai-En Chen, Vikas A. Tillu, Navin Gopaldass, Sudeshna Roy Chowdhury, Natalya Leneva, Oleksiy Kovtun, Juanfang Ruan, Qian Guo, Nicholas Ariotti, Andreas Mayer, Brett M. Collins   +10 more
doaj   +1 more source

A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane

mBio, 2019
Gram-negative bacteria produce lipid-anchored lipoproteins that are trafficked to their outer membrane (OM). These lipoproteins are essential components in each of the molecular machines that build the OM, including the Bam machine that assembles β ...
Kerrie L. May, Kelly M. Lehman, Angela M. Mitchell, Marcin Grabowicz   +3 more
doaj   +1 more source

Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro [PDF]

, 2006
PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 (PC2), the PKD2 protein, is a nonselective Ca2 + -permeable cation channel which may function at the cell surface and ER. Nevertheless, the factors
Kane, M.E., Moon, D.J., Obara, T., Ong, A.C.M., Streets, A.J.   +4 more
core   +2 more sources