Results 71 to 80 of about 2,522,691 (166)

Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene [PDF]

, 2010
National Institutes of Health [R01-CA-113962, R56-DK08512, R01-DK085121, R01 DK068157]; American Diabetes Association [7-07-RA-60]A hallmark of diabetes is an absolute or relative reduction in the number of functional beta cells.
Haoren Wang, Xianxin Hua, Yuqing Yang, Doris A. Stoffers, Ting Wu, Wang, HR, Yang, YQ, Gurung, B, Hua, XX, Wu, T, Stoffers, DA, Buddha Gurung   +11 more
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Successful management of a multiple endocrine neoplasia type 1‐associated thymic neuroendocrine neoplasms with acute chest pain as initial symptom: A rare case report

Clinical Case Reports
Key Clinical Message Acute chest pain can be the first manifestation of multiple endocrine neoplasia type 1(MEN1)‐associated thymic neuroendocrine neoplasms (NEN). Comprehensive treatment may be an effective strategy for MEN1‐associated NEN.
Xuesong Li, Liangbiao Gu, Wenhui Zhao, Zhuo Yu, Jianzhong Xiao, Chenxiang Cao   +5 more
doaj   +1 more source

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, Volume 269, Issue 4-5, Page 387-398, August 2026.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

Animal models of MEN1.

, 2017
Animal models of cancer have been instrumental in advancing our understanding of the biology of tumor initiation and progression, in studying gene function and in performing preclinical studies aimed at testing novel therapies.
Natalia S Pellegata, Pellegata, N.S., Hermine Mohr, Mohr, H., Mohr H., Pellegata N. S.   +5 more
core   +1 more source

Blocking SETD2 Enhances the Therapeutic Efficiency of Menin Inhibitor in MLL‐Fusion Leukemia

Cancer Science, Volume 117, Issue 8, Page 2221-2235, August 2026.
Combined SETD2 and menin inhibitors make synergistic effects against MLL‐fusion leukemia; the combination therapy reduces the expression of target genes through blocking transcription elongation and initiation. ABSTRACT During transcriptional elongation, the histone methyltransferase SETD2 binds to RNA polymerase II and deposits trimethylation marks at
Anpei Li, Yuan Zhang, Ziwei Li, Anhao Liu, Li Zhang, Shubin Gao, Xiao Lin, Xiaoming Liu, Huan Li, Guanghui Jin, Bin Xu   +10 more
wiley   +1 more source

Cutaneous Tumors in Patients with Multiple Endocrine Neoplasia Type 1 Show Allelic Deletion of the MEN1 Gene [PDF]

, 1998
Multiple endocrine neoplasia type 1 (MEN1), the heritable tendency to develop tumors of the parathyroid, pituitary, and entero-pancreatic endocrine tissues, is the consequence of a germline mutation in the MEN1 gene.
Marx, Stephen J., Skarulis, Monica, Darling, Thomas N., Vortmeyer, Alexander O., Turner, Maria L., Zhuang, Zhengping, Böni, Roland, Pack, Svetlana   +7 more
core   +1 more source

Generation of two MEN1 knockout lines from a human embryonic stem cell line

Stem Cell Research, 2017
The MEN1 gene is cytogenetically located at 11q13.1 and encodes the nuclear protein menin, which is involved in cell proliferation, apoptosis, differentiation, and metabolism. Here, we generated two MEN1 knockout human embryonic stem cell lines, WAe001-A-
Yanli Liu, Aynisahan Ruzi, Dongsheng Guo, Feima Wu, Haikun Liu, Han Wu, Yuhang Wu, Fang Yuan, Yuanqi Zhuang, Fan Yang, Keyu Lai, Liangxue Lai, Yin-xiong Li   +12 more
doaj   +1 more source

MET‐amplified gastric cancers exhibit co‐amplifications of BRAF, CDK6, and EGFR

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract MET‐positive gastric cancer (GC) has a poor prognosis. In addition, targeting MET with monoclonal antibodies or tyrosine kinase inhibitors had limited success. We searched for additional genetic alterations that might explain the poor outcome of MET‐positive GC and lack of response to MET‐targeted therapies.
Silke Lüschen, Ulrike Ebert, Hans‐Michael Behrens, Sandra Krüger, Dita Ulase, Anu Amallraja, Steffen M. Heckl, Thomas Becker, Philip Rosenstiel, Tobias Meißner, Christoph Röcken   +10 more
wiley   +1 more source

A new double substitution mutation in the MEN1 gene : a limited penetrance and a specific phenotype

, 2013
: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant cancer syndrome that is caused by a germline mutation in the MEN1 gene encoding a tumour-suppressor protein, menin.
Velkeniers, Brigitte, Brigitte Velkeniers, Unuane, David, Bonduelle, Maryse, Urielle Ullmann, Wim Wuyts, Lissens, Willy, Ullmann, Urielle, David Unuane, Wuyts, Wim, Maryse Bonduelle, Willy Lissens   +11 more
core   +1 more source

Cushing's disease as first clinical manifestation of multiple endocrine neoplasia type 1(MEN1) associeted with R460X mutation of MEN1 gene

, 2003
OBJETIVO: A Neoplasia Endocrina Multipla do tipo 1 ( MEN1 ) e uma doenca autossomica dominante causada por mutacao no gene da MEN1. A MEN1 predispoe ao desenvolvimento de tumores em diversos tecidos, principalmente na hipofise, glandulas paratiroides e ...
Matsuzaki, Lisa Nozawa [UNIFESP]
core