Results 81 to 90 of about 2,522,691 (166)

MEN1 Syndrome and Hibernoma: An Uncommonly Recognised Association?

Case Reports in Medicine, 2014
MEN1 syndrome is known to classically result in parathyroid, pituitary, and pancreatic islet cell tumours. However, the potential association of MEN1 syndrome with hibernoma, a benign tumour with differentiation towards brown fat, is far less well known,
Venus Hedayati, Khin Thway, J. Meirion Thomas, Eleanor Moskovic   +3 more
doaj   +1 more source

Multiple Endocrine Neoplasia Type 1 (MEN1): An Update and the Significance of Early Genetic and Clinical Diagnosis

Frontiers in Endocrinology, 2019
Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumor syndrome inherited in an autosomal dominant manner and characterized by a predisposition to a multitude of endocrine neoplasms primarily of parathyroid, enteropancreatic, and anterior ...
Crystal D. C. Kamilaris, Constantine A. Stratakis   +1 more
doaj   +1 more source

Consequence of Menin Deficiency in Mouse Adipocytes Derived by In Vitro Differentiation

International Journal of Endocrinology, 2015
Lipoma in patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome is a type of benign fat-cell tumor that has biallelic inactivation of MEN1 that encodes menin and could serve as a model to investigate normal and pathologic fat-cell ...
Vaishali I. Parekh, Sita D. Modali, Shruti S. Desai, Sunita K. Agarwal   +3 more
doaj   +1 more source

Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene

Epigenetics & Chromatin, 2012
Background The tumor suppressor menin (MEN1) is mutated in the inherited disease multiple endocrine neoplasia type I, and has several documented cellular roles, including the activation and repression of transcription effected by several transcription ...
Auriemma Lauren B, Shah Shaili, Linden Lara M, Henriksen Melissa A   +3 more
doaj   +1 more source

MEN1 gene sequence variant C.[527 G > A] P.[ARG 176 GLN]: Is it pathogenic?

, 2022
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary cancer syndrome caused by germline variants in the MEN1 new gene located on chromosome 11q13.
Gagliardi Irene, Bondanelli Marta, Zanata Isabella, Aliberti Ludovica, Ambrosio Maria Rosaria, Crociara Anna, Tamburini Nicola, Zatelli Maria Chiara   +7 more
core  

Sarcomas arising in MEN1 patients: demonstrating LOH of the MEN1 locus and loss of menin expression [PDF]

Multiple endocrine neoplasia type 1 (MEN1) is a hereditary tumor syndrome characterized by endocrine tumors, typically from parathyroid, pancreatic, or anterior pituitary origin.
Halfdanarson, Thorvardur R, Folpe, Andrew L, Brosens, Lodewijk A A, Meijers, Ruud W J, Sudhakar, Shwetha M, van Leeuwaarde, Rachel S   +5 more
core   +2 more sources

Loss of p27 expression is associated with MEN1 gene mutations in sporadic parathyroid adenomas

, 2017
MEN1 is the main gene responsible for tumorigenesis of syndromic and sporadic primary hyperparathyroidism (PHPT). Germline mutations of the CDKN1B/p27Kip gene have been associated with multiple endocrine tumors in rats and humans.
Cetani, Filomena, Pellegata, Natalia S., Pellegata, N.S., Lee, Misu, Cetani, F., Torregrossa, L., Miccoli, P., MATERAZZI, GABRIELE, Basolo, F., SAPONARO, FEDERICA, Borsari, S., BASOLO, FULVIO, Pellegata, Natalia S, MARCOCCI, CLAUDIO, Paltrinieri, Elena, Lee, M.S., Marcocci, C., PARDI, ELENA, Torregrossa, Liborio, MICCOLI, PAOLO, Materazzi, G., Zatelli, M.C., Pardi, E., Zatelli, Maria Chiara, Paltrinieri, E., BORSARI, SIMONA, Saponaro, F.   +26 more
core   +1 more source

Syndromic MEN1 parathyroid adenomas consist of both subclonal nodules and clonally independent tumors. [PDF]

Primary hyperparathyroidism with parathyroid tumors is a typical manifestation of Multiple Endocrine Neoplasia Type 1 (MEN1) and is historically termed "primary hyperplasia".
Mazal, Peter, Niederle, Bruno, Grob, Tobias, Neuenschwander, Maja, Kaderli, Reto M, Köhn, Nastassja, Di Domenico, Annunziata, Trepp, Roman, Nesti, Cédric, Scheuba, Christian, Perren, Aurel, Bräutigam, Konstantin, Riss, Philipp   +12 more
core   +2 more sources

Five Advances in the Last 50 Years That Have Impacted Endocrine Surgery

World Journal of Surgery, Volume 50, Issue 8, Page 2071-2076, August 2026.
Matilda Anneback, Priya H. Dedhia, Aimee Di Marco, Els Nieveen van Dijkum, Julie A. Miller, Janice L. Pasieka   +5 more
wiley   +1 more source

Novel germline mutations of the MEN1 gene in Greek families with multiple endocrine neoplasia type 1

, 2009
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary disorder associated with mutations of the MEN1 gene and characterized by the combined occurrence of tumours of the parathyroid glands, the pancreatic islet cells and the ...
Koutsodontis, Georgios, Kamakari, Smaragda, Pikounis, Raptis, Boutati, Eleni, Metaxa-Mariatou, Vassiliki, Peros, Georgios, Vasilios, Hadjidakis, Dimitrios, Peppa, Melpomeni, Economopoulos, Theofanis, Sotirios A.   +11 more
core   +1 more source