Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. [PDF]
, 2018 Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative ...
Abecasis, Goncalo +36 more
core +2 more sources
Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
Genetic Epidemiology, 2013 Genome‐wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potentially a powerful source of data for Mendelian randomization investigations.
S. Burgess, A. Butterworth, S. Thompson
semanticscholar +1 more source
Bias correction for inverse variance weighting Mendelian randomization
bioRxiv, 2022 Inverse-variance weighted two-sample Mendelian randomization (IVW-MR) is the most widely used approach that utilizes genome-wide association studies (GWAS) summary statistics to infer the existence and the strength of the causal effect between an ...
N. Mounier, Z. Kutalik
semanticscholar +1 more source
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
bioRxiv, 2017 Background Mendelian randomisation (MR) is being increasingly used as a strategy to improve causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association ...
F. Hartwig, G. Davey Smith, J. Bowden
semanticscholar +1 more source
Cancer Medicine, 2023 Metabolic disorders are a hallmark feature of cancer. However, the evidence for the causality of circulating metabolites to promote or prevent colorectal cancer (CRC) is still lacking.
Zhangjun Yun +6 more
semanticscholar +1 more source
Interaction Between Mendelian and Non-Mendelian Genes. Regulation of the Transmission of Non-Mendelian Genes by a Mendelian Gene In Chlamydomonas reinhardtii [PDF]
Proceedings of the National Academy of Sciences, 1974 The non-Mendelian genetic element of a given mating type of Chlamydomonas reinhardtii was first doubly marked by succesive mutageneses and then transferred into a number of offspring cells of the opposite mating type.
O M, Chu-Der, K S, Chiang
openaire +2 more sources
Evolution of dominance in gene expression pattern associated with phenotypic robustness
BMC Ecology and Evolution, 2021 Background Mendelian inheritance is a fundamental law of genetics. When we consider two genomes in a diploid cell, a heterozygote’s phenotype is dominated by a particular homozygote according to the law of dominance.
Kenji Okubo, Kunihiko Kaneko
doaj +1 more source
Causal analysis between gastro-oesophageal reflux disease and obstructive sleep apnoea
ERJ Open Research, 2023 Background Based on evidence from existing observational research, clarifying the causal relationship between gastro-oesophageal reflux disease (GORD) and obstructive sleep apnoea (OSA) is challenging.
Gui Chen +8 more
doaj +1 more source
Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer disease [PDF]
, 2017 Alzheimer disease (AD), Frontotemporal lobar degeneration (FTD), Amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) have a certain degree of clinical, pathological and molecular overlap.
Alexandra Medvedeva +17 more
core +4 more sources
Nature Communications, 2023 We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1 million control individuals of European ancestry to uncover novel genetic determinants for heart ...
Danielle Rasooly +33 more
semanticscholar +1 more source