Results 101 to 110 of about 95,337 (328)

Early diagnostic value of novel biomarkers for breast cancer therapy‐related cardiac dysfunction

ESC Heart Failure, EarlyView.
Our meta‐analysis revealed significant post‐treatment increases in GDF‐15, CRP, MPO, and PLGF levels (Gal‐3 unchanged) among breast cancer patients. Only elevated MPO levels were significantly associated with an increased risk of cancer therapy‐related cardiac dysfunction (CTRCD).
Zhengwei Wang, Yujuan Wu, Jingyi He, Diansa Gao, Zhong Zuo   +4 more
wiley   +1 more source

Genetic Markers as Instrumental Variables [PDF]

The use of genetic markers as instrumental variables (IV) is receiving increasing attention from epidemiologists, economists, statisticians and social scientists.
Carol Propper, Debbie A. Lawlor, Frank Windmeijer, George Davey Smith, Stephanie von Hinke Kessler Scholder   +4 more
core  

MR-PheWAS:Hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization [PDF]

, 2015
Observational cohort studies can provide rich datasets with a diverse range of phenotypic variables. However, hypothesis-driven epidemiological analyses by definition only test particular hypotheses chosen by researchers.
Davey Smith, George, Davies, Neil M, Flach, Peter A, Millard, Louise A C, Tilling, Kate M, Timpson, Nicholas John   +5 more
core   +1 more source

Dietary-Derived Essential Nutrients and Amyotrophic Lateral Sclerosis: A Two-Sample Mendelian Randomization Study [PDF]

, 2022
Kailin Xia, Yajun Wang, Linjing Zhang, Lu Tang, Gan Zhang, Tao Huang, Ninghao Huang, Dongsheng Fan   +7 more
openalex   +1 more source

Gastroesophageal reflux disease and risk of atrial fibrillation/flutter: Implications for heart failure progression

ESC Heart Failure, EarlyView.
Abstract Aims While observational studies suggest an association between gastroesophageal reflux disease (GERD) and atrial fibrillation/flutter (AF/AFL), the causal relationship and mechanisms remain undefined. This study employed Mendelian randomization (MR) to assess bidirectional causal relationships and explore potential implications for heart ...
Wansong Hu, Yingxing Wu, Wanqian Yu, Ping Li   +3 more
wiley   +1 more source

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score [PDF]

, 2019
Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science.
Bowden, Jack, Hemani, Gibran, Small, Dylan S., Wang, Jingshu, Zhao, Qingyuan   +4 more
core   +1 more source

Assumptions of IV Methods for Observational Epidemiology

, 2010
Instrumental variable (IV) methods are becoming increasingly popular as they seem to offer the only viable way to overcome the problem of unobserved confounding in observational studies.
Didelez, Vanessa, Meng, Sha, Sheehan, Nuala A.   +2 more
core   +1 more source

Risk of Esophageal Adenocarcinoma Decreases With Height, Based on Consortium Analysis and Confirmed by Mendelian Randomization [PDF]

, 2014
Background & Aims Risks for some cancers increase with height. We investigated the relationship between height and risk of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE).
Aaron P. Thrift, Alan G. Casson, Albanes, Anderson, Anna H. Wu, Baum, Brian J. Reid, Chow, Cook, Cook, Cook, Davey Smith, Davey Smith, Davey Smith, Davey Smith, David C. Whiteman, David M. Levine, Douglas A. Corley, Engeland, Geoffrey Liu, Green, Greenland, Harvey A. Risch, Hoyo, Hwang, Jacobson, Kabat, Kabat, Kubo, Lagergren, Lagergren, Laura J. Hardie, Lawlor, Leoncini, Leslie Bernstein, Levine, Liao, Lynn Onstad, Marilie D. Gammon, Nicholas J. Shaheen, Nigel C. Bird, O'Doherty, Palmer, Rubenstein, Staiger, Stein, Thomas L. Vaughan, Thrift, Thrift, Thrift, Thrift, Walter, Weimin Ye, Whiteman, Wong–Ho Chow, Yvonne Romero   +55 more
core   +2 more sources

Integrated trajectories of systolic and diastolic function differentially associate with risk for heart failure with preserved and reduced ejection fraction and proteomic profiles

European Journal of Heart Failure, EarlyView.
Graphical overview of derivation and testing of multiparametric trajectories of cardiac function. This study identified six trajectories of LV systolic and diastolic function from mid‐ to late‐life. Predicted trajectory from single echocardiogram identified four trajectories at differential risk for HFpEF and HFrEF.
Anne Marie Reimer Jensen, James C. Ross, Victoria Arthur, Michael E. Hall, Kunihiro Matsushita, Brandon Lennep, Pamela L. Lutsey, Tor Biering‐Sørensen, Amil M. Shah   +8 more
wiley   +1 more source

Endoplasmic reticulum stress related genome-wide Mendelian randomization identifies therapeutic genes for ulcerative colitis and Crohn’s disease [PDF]

, 2023
Menglong Zou, Qiaoli Liang, Wei Zhang, Ying Zhu, Yin Xu   +4 more
openalex   +1 more source