Results 161 to 170 of about 95,337 (328)

Mendelian Randomization Applied to Neurology

Neurology
The Mendelian randomization (MR) paradigm allows for causal inferences to be drawn using genetic data. In recent years, the expansion of well-powered publicly available genetic association data related to phenotypes such as brain tissue gene expression, brain imaging, and neurologic diseases offers exciting opportunities for the application of MR in ...
Eloi Gagnon, Iyas Daghlas, Loukas Zagkos, Muralidharan Sargurupremraj, Marios K. Georgakis, Christopher D. Anderson, Helene T. Cronje, Stephen Burgess, Benoit J. Arsenault, Dipender Gill   +9 more
openaire   +2 more sources

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

Schizophrenia and Types of Stroke: A Mendelian Randomization Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and ...
Shinya Nakada, Frederick K. Ho, Carlos Celis‐Morales, Jill P. Pell   +3 more
doaj   +1 more source

Functional synergy and genomic linkage of glyphosate resistance traits in Canada fleabane

Pest Management Science, EarlyView.
Stacking target‐site and non‐target‐site glyphosate resistance mechanisms in Conyza canadensis results in strong synergistic effects. This study quantifies gene × gene interactions and maps linked resistance loci, advancing our understanding of herbicide resistance genetics and informing management strategies.
Eric R Page, Sara L Martin, Sydney Meloche, Alyssa Thibodeau, Martin Laforest   +4 more
wiley   +1 more source

Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and parental negative control studies

, 2019
Judith S. Brand, Romy Gaillard, Jane West, Rosemary McEachan, John Wright, Ellis Voerman, Janine F. Felix, Kate Tilling, Debbie A. Lawlor   +8 more
openalex   +1 more source

Mendelian randomization analysis of druggable gene expression in liver cancer risk and autoimmune hepatitis

Discover Oncology
Background Liver cancer remains one of the most prevalent and lethal malignancies worldwide, while autoimmune hepatitis is an immune-mediated inflammatory liver disease characterized by circulating autoantibodies and distinctive histopathological ...
Mingming Lian, Jun Yao
doaj   +1 more source

Proteome‐Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The proteome is a key source of therapeutic targets. We conducted a comprehensive Mendelian randomization analysis across the proteome to identify potential protein markers and therapeutic targets for abdominal aortic aneurysm (AAA).
Ka Zhang, Yuan Liu, Aiqin Mao, Changzhu Li, Li Geng, Hao Kan   +5 more
doaj   +1 more source

Mendelian Randomization Analysis of the Causal Link Between Rheumatoid Arthritis and Interstitial Lung Disease

Respirology, EarlyView.
This Mendelian randomization study provides genetic evidence supporting a causal effect of rheumatoid arthritis on the risk of interstitial lung disease, highlighting potential shared mechanisms between autoimmune arthritis and pulmonary fibrosis. ABSTRACT Background and Objectives Rheumatoid arthritis (RA) is a systemic autoimmune disease that is ...
Mengyu Zhang, Xiao Chen, Wenqing Zhang, Guang Yang, Yunhong Yin, Yiqing Qu   +5 more
wiley   +1 more source

Commentary: The concept of 'Mendelian Randomization' [PDF]

International Journal of Epidemiology, 2004
Duncan C, Thomas, David V, Conti
openaire   +2 more sources

Impact of Time Since Diagnosis and Age on Fracture Risk in Young Adults With Type 1 and Type 2 Diabetes

The Kaohsiung Journal of Medical Sciences, EarlyView.
Tien‐Ching Lee, Sung‐Yen Lin, Chung‐Hwan Chen, Pei‐Shan Ho   +3 more
wiley   +1 more source