Results 1 to 10 of about 5,777 (152)

The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease [PDF]

Biomolecules, 2022
There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most research has suggested that cerebral small vessel disease (CSVD) is the main contributor to VCI. Several potential physiopathologic mechanisms have been proven to be
Yu Tian, Mengxi Zhao, Yiyi Chen, Mo Yang, Yilong Wang   +4 more
doaj   +6 more sources

Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels [PDF]

Frontiers in Immunology, 2020
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint, László Bálint, Zsombor Ocskay, Zsombor Ocskay, Bálint András Deák, Bálint András Deák, Petra Aradi, Petra Aradi, Zoltán Jakus, Zoltán Jakus   +9 more
doaj   +7 more sources

Role of meningeal lymphatic vessels in brain homeostasis [PDF]

Frontiers in Immunology
Meningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis.
Meng-Ying Zhao, Chao-Yuan Ye, Yuan-Cheng Liu, Xiao-Ming Wang, Jun-Cai Fu, Xin-Yuan Liu, Rui Zhu, Yi-Zhao Li, Qing Tian   +8 more
doaj   +5 more sources

Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels [PDF]

Acta Neuropathologica Communications, 2020
Subdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now.
Xuanhui Liu, Chuang Gao, Jiangyuan Yuan, Tangtang Xiang, Zhitao Gong, Hongliang Luo, Weiwei Jiang, Yiming Song, Jinhao Huang, Wei Quan, Dong Wang, Ye Tian, Xintong Ge, Ping Lei, Jianning Zhang, Rongcai Jiang   +15 more
doaj   +6 more sources

Long-term exercise enhances meningeal lymphatic vessel plasticity and drainage in a mouse model of Alzheimer's disease [PDF]

Translational Neurodegeneration
Background Meningeal lymphatic drainage is crucial for the clearance of amyloid β (Aβ), supporting the maintenance of brain homeostasis. This makes it a promising therapeutic target for Alzheimer's disease (AD).
Yan Chen, Jiachen Cai, Yuzhu She, Xiaoxin He, Hu Feng, Xuewei Li, Yiran Wei, Yi Fan, Wen-e Zhao, Mengmei Yin, Linjuan Yuan, Yuxi Jin, Fengfei Ding, Chengyu Sheng, Junying Gao, Qian Li, Ming Xiao   +16 more
doaj   +6 more sources

The Interplay between Meningeal Lymphatic Vessels and Neuroinflammation in Neurodegenerative Diseases. [PDF]

Curr Neuropharmacol, 2022
Abstract: Meningeal lymphatic vessels (MLVs) are essential for the drainage of cerebrospinal fluid, macromolecules, and immune cells in the central nervous system. They play critical roles in modulating neuroinflammation in neurodegenerative diseases. Dysfunctional MLVs have been demonstrated to increase neuroinflammation by horizontally blocking the ...
Chen J, Pan Y, Liu Q, Li G, Chen G, Li W, Zhao W, Wang Q.   +7 more
europepmc   +5 more sources

Overview of the meningeal lymphatic vessels in aging and central nervous system disorders. [PDF]

Cell Biosci, 2022
AbstractIn the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even cerebrovascular disease. These findings reveal a new perspective on aging and CNS disorders and provide a
Jiang H, Wei H, Zhou Y, Xiao X, Zhou C, Ji X.   +5 more
europepmc   +6 more sources

The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders. [PDF]

J Cereb Blood Flow Metab, 2022
The recent discovery of the meningeal lymphatic vessels (mLVs) and glymphatic pathways has challenged the long-lasting dogma that the central nervous system (CNS) lacks a lymphatic system and therefore does not interact with peripheral immunity. This discovery has reshaped our understanding of mechanisms underlying CNS drainage.
Li G, Cao Y, Tang X, Huang J, Cai L, Zhou L.   +5 more
europepmc   +5 more sources

Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice. [PDF]

J Clin Invest, 2023
Matrongolo MJ, Ang PS, Wu J, Jain A, Thackray JK, Reddy A, Sung CC, Barbet G, Hong YK, Tischfield MA.   +9 more
europepmc   +5 more sources

Inactivation of ERK1/2 signaling mediates dysfunction of basal meningeal lymphatic vessels in experimental subdural hematoma. [PDF]

Theranostics, 2023
Yuan J, Liu X, Nie M, Chen Y, Liu M, Huang J, Jiang W, Gao C, Quan W, Gong Z, Xiang T, Zhang X, Sha Z, Wu C, Wang D, Li S, Zhang J, Jiang R.   +17 more
europepmc   +3 more sources