Results 11 to 20 of about 6,015 (163)

Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels. [PDF]

Front Immunol, 2019
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the role of meningeal lymphatics in the pathogenesis of Alzheimer's disease and multiple sclerosis was ...
Bálint L, Ocskay Z, Deák BA, Aradi P, Jakus Z.   +4 more
europepmc   +11 more sources

The Interplay between Meningeal Lymphatic Vessels and Neuroinflammation in Neurodegenerative Diseases. [PDF]

Curr Neuropharmacol
Abstract: Meningeal lymphatic vessels (MLVs) are essential for the drainage of cerebrospinal fluid, macromolecules, and immune cells in the central nervous system. They play critical roles in modulating neuroinflammation in neurodegenerative diseases. Dysfunctional MLVs have been demonstrated to increase neuroinflammation by horizontally blocking the ...
Chen J, Pan Y, Liu Q, Li G, Chen G, Li W, Zhao W, Wang Q.   +7 more
europepmc   +3 more sources

Advancing insights into in vivo meningeal lymphatic vessels with stereoscopic wide-field photoacoustic microscopy. [PDF]

Light Sci Appl
AbstractMeningeal lymphatic vessels (mLVs) play a pivotal role in regulating metabolic waste from cerebrospinal fluid (CSF). However, the current limitations in field of view and resolution of existing imaging techniques impede understanding the stereoscopic morphology and dynamic behavior of mLVs in vivo.
Yang F, Wang Z, Shi W, Wang M, Ma R, Zhang W, Li X, Wang E, Xie W, Zhang Z, Shen Q, Zhou F, Yang S.   +12 more
europepmc   +4 more sources

Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage. [PDF]

J Neuroinflammation
Abstract Background Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disorder primarily caused by the rupture of aneurysm, which results in a high mortality rate and consequently imposes a significant burden on society. The occurrence of SAH initiates an immune response that further exacerbates brain damage.
Gao D, Zou B, Zhu K, Bi S, Zhang W, Yang X, Lai J, Liang G, Pan P.   +8 more
europepmc   +4 more sources

Meningeal lymphatic vessels in the human head: Examples of in vivo visualization with high-resolution 3T MRI [PDF]

, 2020
In 2015, meningeal lymphatic vessels (mLVs) were (re)discovered in mice and human dura specimens. Two years later, the first report was published showing that mLVs can be detected in humans in vivo by high-resolution 3 Tesla magnetic resonance imaging (MRI).
Scholkmann, Felix, Restin, Tanja
openaire   +2 more sources

Meningeal Lymphatic Vessels: A Drain of the Brain Involved in Neurodegeneration? [PDF]

Neurosci Bull, 2020
Cheng Y, Wang YJ, Wang YJ.
europepmc   +4 more sources

Inactivation of ERK1/2 signaling mediates dysfunction of basal meningeal lymphatic vessels in experimental subdural hematoma. [PDF]

Theranostics
Rationale: Meningeal lymphatic vessels (MLVs) are essential for the clearance of subdural hematoma (SDH). However, SDH impairs their drainage function, and the pathogenesis remains unclear. Herein, we aimed to understand the pathological mechanisms of MLV dysfunction following SDH and to test whether atorvastatin, an effective drug for SDH clearance ...
Yuan J, Liu X, Nie M, Chen Y, Liu M, Huang J, Jiang W, Gao C, Quan W, Gong Z, Xiang T, Zhang X, Sha Z, Wu C, Wang D, Li S, Zhang J, Jiang R.   +17 more
europepmc   +3 more sources

Imaging brain fluid dynamics and waste clearance involving perivascular spaces in cerebral small vessel disease. [PDF]

Alzheimers Dement
Abstract Cerebral small vessel disease (SVD) is recognized as a major vascular contributor to cognitive decline, ultimately leading to dementia and stroke. While the pathogenesis of SVD remains unclear, emerging evidence suggests that waste clearance involving perivascular space (PVS) – also known as the glymphatic system – dysfunction may play a role.
Solé-Guardia G, Li H, Willemse L, Lebenberg J, Jouvent E, Tuladhar AM.   +5 more
europepmc   +2 more sources

Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood-brain barrier: mechanisms of brain clearing. [PDF]

J Biomed Opt, 2017
The meningeal lymphatic vessels were discovered 2 years ago as the drainage system involved in the mechanisms underlying the clearance of waste products from the brain.
Semyachkina-Glushkovskaya O, Abdurashitov A, Dubrovsky A, Bragin D, Bragina O, Shushunova N, Maslyakova G, Navolokin N, Bucharskaya A, Tuchin V, Kurths J, Shirokov A.   +11 more
europepmc   +3 more sources

The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception [PDF]

, 2022
A system of lymphatic vessels has been recently characterized in the meninges, with a postulated role in 'cleaning' the brain via cerebral fluid drainage.
Abdollahzadeh, Ali, Eme-Scolan, Elisa, Gafurov, Oleg, Giniatullin, Rashid, Giniatullina, Raisa, Hamalainen, Riikka H., Koroleva, Kseniia, Krivoshein, Georgii, Malm, Tarja, Mikhailov, Nikita, Noe, Francesco M., Rua, Rejane, Sierra, Alejandra, Teleman, Matei, Tohka, Jussi, Virenque, Anais   +15 more
core   +2 more sources