Tertiary lymphoid organs in central nervous system autoimmunity [PDF]
, 2016 Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Mitsdoerffer, M., Peters, A.
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Remarkable preservation of brain tissues in an Early Cretaceous iguanodontian dinosaur [PDF]
, 2016 It has become accepted in recent years that the fossil record can preserve labile tissues. Here we report highly detailed mineralisation of soft tissues associated with a naturally occurring brain endocast of an iguanodontian dinosaur, found in ~133 Ma ...
Antcliffe, Jonathan B. +11 more
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Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions
Frontiers in Neuroscience, 2023 The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Alexandra Melloni +8 more
doaj +1 more source
Dorsal skull meningeal lymphatic vessels drain blood-solutes after intracerebral hemorrhage [PDF]
, 2021 AbstractDrainage of intraparenchymal hematoma is crucial for the treatment of intracerebral hemorrhage (ICH). We investigated here the possible function of the meningeal lymphatic vessels (mLVs) in ICH resolution. Meningeal lymphatics have been reported to be involved in cerebrospinal fluid drainage, but their role in the drainage and clearance of ...
Anaïs Virenque +2 more
openaire +1 more source
Pathogenetical significance of porencephalic lesions associated with intracerebral inoculation of sheep with the bovine spongiform encephalopathy (BSE) agent [PDF]
, 2009 Decreased rates of transmission of transmissible spongiform encephalopathies (TSEs) to sheep have been attributed to some polymorphisms of the prion protein (PrP) and to a ‘species barrier’ on interspecies experiments.
Card +21 more
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Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development [PDF]
, 2017 The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals brain lymphatics were only recently discovered, with significant implications for physiology and disease. We examined zebrafish
Hawkins, TA +5 more
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Mapping meningeal vasculature in non-human primates
Veins and Lymphatics, 2022 Background. The blood-brain barrier has been the focus of most prior work examining intracranial vasculature in the context of various brain diseases.1 Recently, meningeal vasculature has become more widely recognized as a key contributor to brain ...
Christopher Janson +4 more
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Editorial: tertiary lymphoid organs (TLOs): powerhouses of disease immunity [PDF]
, 2017 No abstract ...
Habenicht, Andreas J.R. +3 more
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Spontaneous activity in peripheral diaphragmatic lymphatic loops. [PDF]
, 2013 The spontaneous contractility of FITC-dextran-filled lymphatics at the periphery of the pleural diaphragm was documented for the first time “in vivo” in anesthetized Wistar rats. We found that lymphatic segments could be divided into four phenotypes: 1)
Marcozzi C +3 more
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Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective
Neuroscience Insights, 2019 The recent discovery of lymphatic vessels in the meningeal layers calls into question the known mechanisms of fluid and macromolecule homeostasis and immunoregulation within the central nervous system.
Korri S Hershenhouse +3 more
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