Results 41 to 50 of about 6,015 (163)

Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases [PDF]

, 2023
Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS).
Blokhina, Inna, Fedosov, Ivan, Kaybeleva, Elmira, Khorovodov, Alexander, Kurths, Jürgen, Li, Dongyu, Penzel, Thomas, Saranceva, Elena, Semyachkina-Glushkovskaya, Oxana, Telnova, Valeria, Terskov, Andrey, Yu, Tingting, Zhu, Dan   +12 more
core   +1 more source

Magnetic resonance imaging of cerebrospinal fluid outflow after low-rate lateral ventricle infusion in mice. [PDF]

, 2021
The anatomical routes for the clearance of cerebrospinal fluid (CSF) remain incompletely understood. However, recent evidence has given strong support for routes leading to lymphatic vessels. A current debate centers upon the routes through which CSF can
Decker, Yann, Fassbender, Klaus, Krämer, Jonas, Müller, Andreas, Proulx, Steven T., Scheller, Anja, Xin, Li   +6 more
core   +2 more sources

A Live Cell Imaging‐Compatible Bioreactor for the Interrogation of Cellular Responses to Modulated Flow Conditions

Advanced Science, EarlyView.
An open‐source, low‐cost 3D perfusion system integrating bioprinted scaffolds and live‐imaging overcomes 2D culture limitations. Modeling the cerebrospinal fluid‐filled subarachnoid space, it reveals flow‐dependent focal adhesion kinase activation in meningothelial cells, demonstrating a powerful platform for studying mechanobiology and creating ...
Subashree Srinivasan, Valerie H. Huhle, Claudia C. Bippes, Nina Tanner, Stephan Frank, Hanspeter E. Killer, Corina Kohler, Albert Neutzner   +7 more
wiley   +1 more source

Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation [PDF]

, 2023
Acute sleep deprivation has been shown to affect cerebrospinal fluid and plasma concentrations of biomarkers associated with neurodegeneration, though the mechanistic underpinnings remain unknown.
Blennow, Kaj, Eide, Per Kristian, Hovd, Markus, Lashkarivand, Aslan, Pripp, Are Hugo, Ringstad, Geir, Valnes, Lars Magnus, Zetterberg, Henrik   +7 more
core  

Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The aim was to investigate if glymphatic function is impaired in patients with Huntington's disease (HD) and its clinical relevance. Methods Forty‐nine subjects carrying mutant Huntingtin (mHTT), comprising 35 manifest (mHD) and 14 pre‐manifest (PreHD), and 35 healthy controls (HC) were recruited in this study.
Jin‐Hui Yin, Ling‐Xiao Cao, Ya‐Ou Liu, Yue Huang   +3 more
wiley   +1 more source

Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart

Aging Cell, EarlyView.
Exercise improves cardiac lymphatic architecture and function in the aged mouse. Aged hearts show reduced lymphatic vascular density, more dilated vessels, and increased peri‐lymphatic inflammation and fibrosis. Exercise training of the aged mouse increases lymph vessel density and sprouting, reverses their dilation, reduces inflammation and fibrosis ...
Kangsan Roh, Haobo Li, Rebecca Nicole Freeman, Luca Zazzeron, Ahlim Lee, Charles Zhou, Siman Shen, Peng Xia, Justin Ralph Baldovino Guerra, Cedric Sheffield, Timothy P. Padera, Yirong Zhou, Sekeun Kim, Aaron Aguirre, Nicolas Houstis, Jason D. Roh, Fumito Ichinose, Rajeev Malhotra, Anthony Rosenzweig, James Rhee   +19 more
wiley   +1 more source

Cryptococcal meningitis due to Cryptococcus neoformans VNI in a koala (Phascolarctos cinereus) with progressive neurological disease

Australian Veterinary Journal, EarlyView.
Nearly all cases of cryptococcosis in koalas are caused by Cryptococcus gattii species complex. A rare case of meningitis due to Cryptococcus neoformans VNI/AFLP1 (abbreviated VNI) is described in a koala with nasal colonisation by both species complexes.
A Teh, R Crisman, E Dwars, R Malik, LH de Miranda, W Meyer, M Krockenberger   +6 more
wiley   +1 more source

VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation. [PDF]

, 2023
Meninges cover the surface of the brain and spinal cord and contribute to protection and immune surveillance of the central nervous system (CNS). How the meningeal layers establish CNS compartments with different accessibility to immune cells and immune ...
Andrae, Johanna, Barcos, Sara, Betsholtz, Christer, Bouillet, Elisa, Deutsch, Urban, Engelhardt, Britta, Hélie, Pauline, Mapunda, Josephine A, McDonald, Donald M, Pareja, Javier, Pleskač, Petr, Proulx, Steven T, Vestweber, Dietmar, Vladymyrov, Mykhailo   +13 more
core   +1 more source

Opportunities to Modulate Tumor Ecosystem Toward Successful Glioblastoma Immunotherapy

Cancer Science, EarlyView.
There remain outstanding gaps between the negative results from clinical trials and the actual potential of the immune system for glioblastoma. To bridge this crucial gap, we collaborated with Dr. Mariko Takahashi, an expert in immunobiology and drug development, and Dr. James J.
Mariko Takahashi, Darina Mukhamejanova, Himani Jasewicz, Nandini Acharya, James J. Moon, Toshiro Hara   +5 more
wiley   +1 more source

Brain lymphatic vessels accompanying meningeal arteries in the human

Translational Research in Anatomy
Introduction: Recent studies showed the connection between cerebrospinal fluid (CSF) and deep cervical lymph nodes (dCLN) via lymphatic vessels (LV)s. These LVs accompany dural sinuses, cranial nerves, and arteries. The present study aimed to show in addition to the main trunk of the middle meningeal artery (MMA) whether the anterior and posterior ...
Safiye Çavdar, Damlasu Altınöz, Tevriz Dilan Demir, Acar Bayraktaroğlu, İlke Ali Gürses, Gülnihal Özcan   +5 more
openaire   +2 more sources