Results 121 to 130 of about 4,490 (191)
Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes [PDF]
In animal models, brain neurodegeneration biomarkers drain into cervical lymph nodes (CLNs), and this drainage function is reduced with ageing. If this occurred in humans, CLNs may provide a readily accessible measure of this aspect of protein clearance.
Al-Diwani, Adam +11 more
core +5 more sources
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis [PDF]
Dysfunctional lymphatic drainage from the central nervous system (CNS) has been linked to neuroinflammatory and neurodegenerative disorders, but our understanding of the lymphatic contribution to CNS fluid autoregulation remains limited. Here, we studied
Gibson, Daniel A +5 more
core +2 more sources
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges [PDF]
, 2019 The vertebrate CNS is surrounded by the meninges, a protective barrier comprised of the outer dura mater and the inner leptomeninges, which includes the arachnoid and pial layers.
Barber, M +15 more
core
Brain Pathology, Volume 36, Issue 2, March 2026.Mesenchymal stromal cell‐and fibroblast‐expressing Linx paralogue (Meflin) is expressed in embryonic meninges and contributes to meningeal homeostasis. In meningiomas, elevated Meflin correlates with higher grade and recurrence. Single‐cell RNA sequencing revealed a Meflin‐high tumor cell subset marked by reduced proliferation, WNT6 expression, and ...
Yukihiro Shiraki +13 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION This study evaluated the efficacy of deep cervical lymphatic–venous anastomosis (dcLVA) for severe Alzheimer's disease (AD). METHODS A total of 139 severe AD patients undergoing dcLVA were enrolled, and changes in cognitive function and biomarkers were evaluated by comparing preoperative measures with postoperative outcomes over a
Xiaohong Fu +15 more
wiley +1 more source
No Glymphatic Dysfunction in Trigeminal Neuralgia: A Preliminary Study
Brain and Behavior, Volume 16, Issue 2, February 2026.In this study investigating cross‐sectional and longitudinal DTI‐ALPS changes in patients with trigeminal neuralgia, no DTI‐ALPS alterations were detected in trigeminal neuralgia patients. ABSTRACT Background Trigeminal neuralgia (TN) patients are at risk for glymphatic dysfunction due to their prolonged headaches and sleep disturbances.
Barış Genç, Kerim Aslan
wiley +1 more source
Scalp Melanoma in a Young Patient With Systemic Sarcoidosis: Multidisciplinary Approach
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT Often discovered at late stages, scalp melanoma presents unique diagnostic difficulties. Timely detection via public awareness, education, and comprehensive clinical assessment is essential for survival rate improvement. This case report shows the significance of multidisciplinary care and targeted therapies which can achieve remission even in
Nicolò Mori +17 more
wiley +1 more source
Piezo1 Regulates Meningeal Lymphatic Vessel Drainage and Alleviates Excessive Csf Accumulation [PDF]
Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for the proper development and function of meningeal lymphatic vessels and
Choi, Dongwon +15 more
core +2 more sources
Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders [PDF]
, 2023 Clearance of neurotoxic brain proteins via cerebrospinal fluid (CSF) to blood has recently emerged to be crucial, and plasma biomarkers of neurodegeneration were newly introduced to predict neurological disease.
Blennow, Kaj +7 more
core